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The breakdown of the blood-brain barrier allows immune cell infiltration, intensifying inflammation. A decreased ratio of Connexin-37 (Cx37, also known as GJA4: Gap Junction Protein Alpha 4) and Prolyl Hydroxylase Domain-Containing Protein 3 (PHD3, also known as EGLN3: Egl-9 Family Hypoxia Inducible Factor 3), Cx37\/PHD3, consistently observed in different AD-related models, may represent a novel potential biomarker of AD, albeit the exact mechanisms underlying this phenomenon, most likely based on gap junction-mediated cellular interaction that modulate the cellular metabolite status, remain to be fully elucidated.<\/jats:p>","DOI":"10.3233\/jad-231464","type":"journal-article","created":{"date-parts":[[2024,2,2]],"date-time":"2024-02-02T10:47:10Z","timestamp":1706870830000},"page":"1685-1687","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Leukocytes and Endothelial Cells Participate in the Pathogenesis of Alzheimer\u2019s Disease: Identifying New Biomarkers Mirroring Metabolic Alterations"],"prefix":"10.1177","volume":"97","author":[{"given":"Pasquale","family":"Mone","sequence":"first","affiliation":[{"name":"Department of Molecular Pharmacology, Einstein Institute for Neuroimmunology and Inflammation, Albert Einstein College of Medicine, New York, NY, USA"},{"name":"Department of Medicine and Health Sciences, University of Molise, Campobasso, Italy"},{"name":"Casa di Cura \u201cMontevergine\u201d, Mercogliano (Avellino), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Mental and Physical Health and Preventive Medicine, University of Campania \u201cLuigi Vanvitelli\u201d, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urna","family":"Kansakar","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Einstein Institute for Neuroimmunology and Inflammation, Albert Einstein College of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano","family":"Santulli","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmacology, Einstein Institute for Neuroimmunology and Inflammation, Albert Einstein College of Medicine, New York, NY, USA"},{"name":"Department of Advanced Biomedical Sciences, University of Naples \u201cFederico II\u201d, Naples, Italy"},{"name":"Department of Medicine, Einstein Institute for Aging Research, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04369-3"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac236"},{"key":"ref003","first-page":"9","volume":"7","author":"Mone P","year":"2021","journal-title":"Noncoding RNA"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.06.014"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac354"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230874"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2022.10.010"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2022.12.010"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.759159"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1191426"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-231464","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-231464","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-231464","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:09:27Z","timestamp":1777370967000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-231464"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,31]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,2,13]]}},"alternative-id":["10.3233\/JAD-231464"],"URL":"https:\/\/doi.org\/10.3233\/jad-231464","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,31]]}}}