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Nevertheless, the efficacy of tDCS in treating AD is still debated. Dorsal lateral prefrontal cortex is the main role in executive functions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We investigate the cognitive effects of tDCS on AD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Thirty mild AD patients aged 66\u201386 years (mean\u200a=\u200a75.6) were included in a double-blind, randomized, sham-controlled crossover study. They were randomly assigned to receive 10 consecutive daily sessions of active tDCS (2\u200amA for 30\u200amin) or a sham intervention and switched conditions 3 months later. The anodal and cathodal electrodes were placed on the left dorsal lateral prefrontal cortex and the right supraorbital area, respectively. Subjects underwent various neuropsychological assessments before and after the interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The results showed that tDCS significantly improved Cognitive Abilities Screening Instrument scores, especially on the items of \u201cconcentration and calculation\u201d, \u201corientation\u201d, \u201clanguage ability\u201d, and \u201ccategorical verbal fluency\u201d. Mini-Mental State Examination and Wisconsin Card Sorting Test scores in all domains of \u201cconcept formation\u201d, \u201cabstract thinking\u201d, \u201ccognitive flexibility\u201d, and \u201caccuracy\u201d also improved significantly after tDCS. For the sham condition, no difference was found between the baseline scores and the after-intervention scores on any of the neuropsychological tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>&gt;: Using tDCS improves the cognition of AD patients. Further large size clinical trials are necessary to validate the data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-240002","type":"journal-article","created":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T11:16:04Z","timestamp":1709291764000},"page":"563-577","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":9,"title":["Cognitive Effect of Transcranial Direct Current Stimulation on Left Dorsolateral Prefrontal Cortex in Mild Alzheimer\u2019s Disease: A Randomized, Double-Blind, Cross-Over Small-Scale Exploratory Study"],"prefix":"10.1177","volume":"98","author":[{"given":"Carol Sheei-Meei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of BioMedical Engineering, National Cheng Kung University, Tainan City, Taiwan"},{"name":"Department of Psychiatry, Tainan Hospital, Ministry of Health and Welfare, Tainan City, Taiwan"},{"name":"Department of Psychiatry, College of Medicines, National Cheng Kung University Hospital, National Cheng Kung University, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po See","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicines, National Cheng Kung University Hospital, National Cheng Kung University, Tainan City, Taiwan"},{"name":"Institute of Behavioral Medicine, College of Medicine, National Cheng Kung University, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Yu","family":"Tsai","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicines, National Cheng Kung University Hospital, National Cheng Kung University, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nien-Tsen","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tainan Hospital, Ministry of Health and Welfare, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia-Hung","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Tainan Hospital, Ministry of Health and Welfare, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pai-Lien","family":"Chen","sequence":"additional","affiliation":[{"name":"Biostatistics Department, Family Health International (FHI) 360, Durham, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Che","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, Tainan Hospital, Ministry of Health and Welfare, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuo-Sheng","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of BioMedical Engineering, National Cheng Kung University, Tainan City, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a033118"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132690"},{"key":"e_1_3_6_4_2","first-page":"759","article-title":"Outcomes of Alzheimer\u2019s disease therapy with acetylcholinesterase inhibitors and memantine","volume":"13","author":"Zemek F","year":"2014","unstructured":"ZemekF, DrtinovaL, NepovimovaE, SepsovaV, KorabecnyJ, KlimesJ, KucaK (2014) Outcomes of Alzheimer\u2019s disease therapy with acetylcholinesterase inhibitors and memantine. 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