{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:43:52Z","timestamp":1790117032057,"version":"4.0.1"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T00:00:00Z","timestamp":1714089600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,5,14]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>\n                      Recent interest has surged in the locus coeruleus (LC) for its early involvement in Alzheimer\u2019s disease (AD), notably concerning the apolipoprotein \u025b4 allele (\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>\n                      This study aimed to discern LC functional connectivity (FC) variations in preclinical AD subjects, dissecting the roles of\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carrier status and amyloid-\u03b2 (A\u03b2) deposition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      A cohort of 112 cognitively intact individuals, all A\u03b2-positive, split into 70\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      noncarriers and 42 carriers, underwent functional MRI scans, neuropsychological assessments, and\n                      <jats:italic toggle=\"yes\">APOE<\/jats:italic>\n                      genotyping. The research utilized seed to voxel analysis for illustrating LC rsFC discrepancies between\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      statuses and employed a general linear model to examine the interactive influence of\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carrier status and A\u03b2 deposition on LC FC values.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The investigation revealed no significant differences in sex, age, or SUVR between\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carriers and noncarriers. It found diminished LC FC with the occipital cortex in\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carriers and identified a significant interaction between\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carrier status and temporal lobe SUVR in LC FC with the occipital cortex. This interaction suggested a proportional increase in LC FC for\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carriers. Additional notable interactions were observed affecting LC FC with various brain regions, indicating a proportional decrease in LC FC for\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carriers.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>\n                      These findings confirm that\n                      <jats:italic toggle=\"yes\">APOE4<\/jats:italic>\n                      carrier status significantly influences LC FC in preclinical AD, showcasing an intricate relationship with regional A\u03b2 deposition. This underscores the critical role of genetic and pathological factors in early AD pathophysiology, offering insights into potential biomarkers for early detection and intervention strategies.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-240065","type":"journal-article","created":{"date-parts":[[2024,4,26]],"date-time":"2024-04-26T14:05:03Z","timestamp":1714140303000},"page":"705-714","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Impact of Apolipoprotein E4 on the Locus Coeruleus Functional Connectivity in Preclinical Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"99","author":[{"given":"Yoo Hyun","family":"Um","sequence":"first","affiliation":[{"name":"The Catholic University of Korea","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Min","family":"Wang","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Woo","family":"Kang","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunghwan","family":"Kim","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Uk","family":"Lee","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghyeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeong Sim","family":"Choe","sequence":"additional","affiliation":[{"name":"Research Institute","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina E.Y.","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soyoung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Brigham and Women\u2019s Hospital, Boston, MA, USA"},{"name":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Kook","family":"Lim","sequence":"additional","affiliation":[{"name":"The Catholic University of Korea","place":["Korea"]},{"name":"The Catholic Medical Center of The Catholic University of Korea","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,4,26]]},"reference":[{"key":"e_1_3_6_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-030421-112756"},{"key":"e_1_3_6_3_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-022-00590-4"},{"key":"e_1_3_6_4_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abj2511"},{"key":"e_1_3_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12656"},{"key":"e_1_3_6_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000113716"},{"key":"e_1_3_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.102954"},{"key":"e_1_3_6_8_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180507"},{"key":"e_1_3_6_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.108"},{"key":"e_1_3_6_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02315-1"},{"key":"e_1_3_6_11_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0573-1"},{"key":"e_1_3_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.11.028"},{"key":"e_1_3_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/geronb\/57.1.P47"},{"key":"e_1_3_6_14_2","first-page":"508","article-title":"Standardization of Korean of the mini-mental stateexamination (MMSE-K) for use in the elderly. Part II. Diagnosticvalidity","volume":"28","author":"Park JH","year":"1989","unstructured":"ParkJH (1989) Standardization of Korean of the mini-mental stateexamination (MMSE-K) for use in the elderly. Part II. Diagnosticvalidity. J\u00a0Korean Neuropsychiatr Assoc 28, 508\u2013513.","journal-title":"J\u00a0Korean Neuropsychiatr Assoc"},{"key":"e_1_3_6_15_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1041610297004870"},{"key":"e_1_3_6_16_2","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.114.142109"},{"key":"e_1_3_6_17_2","doi-asserted-by":"publisher","DOI":"10.1089\/brain.2012.0073"},{"key":"e_1_3_6_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.11.006"},{"key":"e_1_3_6_19_2","unstructured":"R Development Core Team (2013) R: A language and environment for statistical computing."},{"key":"e_1_3_6_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac239"},{"key":"e_1_3_6_21_2","doi-asserted-by":"publisher","DOI":"10.3390\/ph13090261"},{"key":"e_1_3_6_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2000.tb06360.x"},{"key":"e_1_3_6_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3806"},{"key":"e_1_3_6_24_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210191"},{"key":"e_1_3_6_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90336-8"},{"key":"e_1_3_6_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci11111485"},{"key":"e_1_3_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103638"},{"key":"e_1_3_6_28_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-009-0343-5"},{"key":"e_1_3_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2023.114231"},{"key":"e_1_3_6_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhx236"},{"key":"e_1_3_6_31_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1125114"},{"key":"e_1_3_6_32_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1197987"},{"key":"e_1_3_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2011.06.009"},{"key":"e_1_3_6_34_2","doi-asserted-by":"publisher","DOI":"10.30773\/pi.2018.06.02"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-240065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-240065","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-240065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T10:08:36Z","timestamp":1777370916000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-240065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,26]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,5,14]]}},"alternative-id":["10.3233\/JAD-240065"],"URL":"https:\/\/doi.org\/10.3233\/jad-240065","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,26]]}}}