{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:57:46Z","timestamp":1787237866326,"version":"build-2736575974"},"reference-count":37,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,5,21]],"date-time":"2024-05-21T00:00:00Z","timestamp":1716249600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,6,11]]},"abstract":"<jats:p>\n                    \u00a0Higher blood pressure variability (BPV) predisposes to cognitive decline. To investigate underlying mechanisms, we measured 24-h ambulatory BPV, nocturnal dipping and orthostatic hypotension in 518 participants with vascular cognitive impairment, carotid occlusive disease, heart failure, or reference participants. We determined cross-sectional associations between BPV indices and plasma biomarkers of neuronal injury (neurofilament light chain) and Alzheimer\u2019s disease (phosphorylated-tau-181 and A\u03b2\n                    <jats:sub>42<\/jats:sub>\n                    \/A\u03b2\n                    <jats:sub>40<\/jats:sub>\n                    ). None of the BPV indices were significantly associated with any of the biomarkers. Hence, in patients with diseases along the heart-brain axis, we found no evidence for an association between BPV and selected markers of neuronal injury or Alzheimer\u2019s disease.\n                  <\/jats:p>","DOI":"10.3233\/jad-240119","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T12:17:08Z","timestamp":1716553028000},"page":"1207-1215","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Blood Pressure Variability and Plasma Biomarkers of Neuronal Injury and Alzheimer\u2019s Disease: A Clinic-Based Study of Patients with Diseases Along the Heart-Brain Axis"],"prefix":"10.1177","volume":"99","author":[{"given":"Naomi Louisa Paula","family":"Starmans","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurens Jaap","family":"Kappelle","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majon","family":"Muller","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Geriatrics Section, Amsterdam Cardiovascular Science, Amsterdam University Medical Center (Amsterdam UMC), Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Staals","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Center, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte Elisabeth","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Department of Clinical Chemistry, Neurochemistry Laboratory, Amsterdam Neuroscience, Amsterdam University Medical Center (Amsterdam UMC), Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert Jan","family":"Biessels","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje Maria","family":"van der Flier","sequence":"additional","affiliation":[{"name":"Department of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Amsterdam University Medical Center (Amsterdam UMC), Amsterdam, The Netherlands"},{"name":"Department of Epidemiology, Amsterdam University Medical Center (Amsterdam UMC), Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank Johannes","family":"Wolters","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands"},{"name":"Department of Radiology and Nuclear Medicine and Alzheimer Center, Erasmus University Medical Center, Rotterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of the Heart-Brain Connection Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,5,21]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.17797"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-023-02361-7"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4964"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.026739"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013841"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00115"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090750"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1038\/srep23964"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.04.023"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-23620-z"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-221287"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200302"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-20627-4"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002167"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12377"},{"key":"ref016","first-page":"14:909582","volume":"14","author":"Li 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