{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T18:07:33Z","timestamp":1780423653109,"version":"3.54.1"},"reference-count":48,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,6,29]],"date-time":"2024-06-29T00:00:00Z","timestamp":1719619200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,7,30]]},"abstract":"\n Background:<\/jats:title>\n Urinary Alzheimer-associated neuronal thread protein (AD7c-NTP) is a biomarker for the early diagnosis of Alzheimer\u2019s disease (AD). It remains unclear whether hepatorenal function affects the urinary AD7c-NTP level.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n To evaluate the effects of hepatorenal function on urinary AD7c-NTP level.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n We enrolled 453 participants aged 60\u2013100 years. An automated chemistry analyzer was used to determine the indicators of serum hepatorenal function. Enzyme-linked immunosorbent assay was used to measure the urinary AD7c-NTP level.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Spearman\u2019s correlation analysis showed a negative correlation between urinary AD7c-NTP levels and indicators of hepatorenal function, including albumin (\n r<\/jats:italic>\n \u200a=\u200a\u20130.181,\n p<\/jats:italic>\n \u200a<\u200a0.001), albumin\/globulin ratio (\n r<\/jats:italic>\n \u200a=\u200a\u20130.224,\n p<\/jats:italic>\n \u200a<\u200a0.001), cholinesterase (\n r<\/jats:italic>\n \u200a=\u200a\u20130.094,\n p<\/jats:italic>\n \u200a=\u200a0.046), total carbon dioxide (\n r<\/jats:italic>\n \u200a=\u200a\u20130.102,\n p<\/jats:italic>\n \u200a=\u200a0.030), and glomerular filtration rate (\n r<\/jats:italic>\n \u200a=\u200a\u20130.260,\n p<\/jats:italic>\n \u200a<\u200a0.001), as well as a positive correlation with globulin (\n r<\/jats:italic>\n \u200a=\u200a0.141,\n p<\/jats:italic>\n \u200a=\u200a0.003), aspartate transaminase (\n r<\/jats:italic>\n \u200a=\u200a0.186,\n p<\/jats:italic>\n \u200a<\u200a0.001), blood urine nitrogen (\n r<\/jats:italic>\n \u200a=\u200a0.210,\n p<\/jats:italic>\n \u200a<\u200a0.001), creatinine (\n r<\/jats:italic>\n \u200a=\u200a0.202,\n p<\/jats:italic>\n \u200a<\u200a0.001), uric acid (\n r<\/jats:italic>\n \u200a=\u200a0.229,\n p<\/jats:italic>\n \u200a<\u200a0.001), and cystatin C (\n r<\/jats:italic>\n \u200a=\u200a0.265,\n p<\/jats:italic>\n \u200a<\u200a0.001). The least absolute shrinkage and selection operator (LASSO) regression analysis and multiple linear regression model analyses showed that the statistically significant hepatorenal indicators for predicting AD7c-NTP were A\/G (\n p<\/jats:italic>\n \u200a=\u200a0.007), AST (\n p<\/jats:italic>\n \u200a=\u200a0.002), BUN (\n p<\/jats:italic>\n \u200a=\u200a0.019), and UA (\n p<\/jats:italic>\n \u200a=\u200a0.003).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n The effects of hepatorenal indicators should be considered when using urinary AD7c-NTP levels in clinical settings.<\/jats:p>\n <\/jats:sec>","DOI":"10.3233\/jad-240148","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T12:14:11Z","timestamp":1719922451000},"page":"911-921","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Hepatorenal Function on Urinary Alzheimer-Associated Neuronal Thread Protein: A Laboratory-Based Cross-Sectional Study Among the Older Chinese Population"],"prefix":"10.1177","volume":"100","author":[{"given":"He","family":"Jin","sequence":"first","affiliation":[{"name":"Capital Medical University","place":["China"]},{"name":"Affiliated Hospital of Guilin Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiu","family":"Yang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guilin Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guodong","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Guilin Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Capital Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Capital Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Wang","sequence":"additional","affiliation":[{"name":"Capital Medical University","place":["China"]},{"name":"Beijing Institute for Brain Disorders","place":["China"]},{"name":"National Clinical Research Center for Geriatric 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