{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:16:28Z","timestamp":1777392988352,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,10,8]]},"abstract":"<jats:p>Background: Semantic intrusion errors (SIEs) are both sensitive and specific to PET amyloid-\u03b2 (A\u03b2) burden in older adults with amnestic mild cognitive impairment (aMCI). Objective: Plasma A\u03b2 biomarkers including the A\u03b242\/40 ratio using mass spectrometry are expected to become increasingly valuable in clinical settings. Plasma biomarkers are more clinically informative if linked to cognitive deficits that are salient to Alzheimer\u2019s disease (AD). Methods: This study included 119 older adults enrolled in the 1Florida Alzheimer\u2019s Disease Research Center (ADRC), 45 aMCI participants scored below the established A\u03b242\/40 ratio cut-off of 0.160 using the Quest AD-Detect\u2122 assay indicating A\u03b2 positivity (A\u03b2+), while 50 aMCI participants scored above this cut-off indicating A\u03b2 negative status (A\u03b2\u2013). Additionally, 24 cognitively unimpaired (CU) persons scored above the cut-off of 0.160 (A\u03b2\u2013). Results: The aMCI plasma A\u03b2+ group evidenced the greatest percentage of SIEs, followed by the aMCI A\u03b2\u2013. The CU A\u03b2\u2013 group exhibited the lowest percentage of SIEs. After adjustment for global cognitive impairment, aMCI plasma A\u03b2+ continued to demonstrate greater SIEs on tests tapping the failure to recover from proactive semantic interference (frPSI) as compared to the aMCI A\u03b2\u2013group. Using pre-established cut-offs for frPSI impairment, 8.3% of CU A\u03b2\u2013 participants evidenced deficits, compared to 37.8% of aMCI A\u03b2\u2013, and 74.0% of aMCI A\u03b2+. Conclusions: SIEs reflecting frPSI were associated with aMCI A\u03b2+ status based on the A\u03b242\/40 ratio. Results suggest the importance of SIEs as salient cognitive markers that map onto underlying AD pathology in the blood.<\/jats:p>","DOI":"10.3233\/jad-240164","type":"journal-article","created":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T13:09:38Z","timestamp":1728392978000},"page":"1195-1204","source":"Crossref","is-referenced-by-count":1,"title":["The Association Between Plasma Amyloid-\u03b2 42\/40 and Percentage of Semantic Intrusion Errors in Mild Cognitive Impairment"],"prefix":"10.1177","volume":"101","author":[{"given":"Rosie E.","family":"Curiel Cid","sequence":"first","affiliation":[{"name":"1Florida Alzheimer\u2019s Disease Research Center (ADRC), Miami, FL, USA"},{"name":"Center for Cognitive Neuroscience and Aging (CNSA), Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, 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