{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:23:07Z","timestamp":1790698987329,"version":"4.1.0"},"reference-count":143,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,7,30]]},"abstract":"<jats:p>Multiple pharmacologic agents now have been approved in the United States and other countries as treatment to slow disease and clinical progression for Alzheimer\u2019s disease. Given these treatments have not been proven to lessen the cognitive deficits already manifested in the Alzheimer\u2019s Clinical Syndrome (ACS), and none are aimed for another debilitating dementia syndrome identified as primary progressive aphasia (PPA), there is an urgent need for new, safe, tolerable, and efficacious treatments to mitigate the cognitive deficits experienced in ACS and PPA. Noninvasive brain stimulation has shown promise for enhancing cognitive functioning, and there has been interest in its potential therapeutic value in ACS and PPA. This review critically examines the evidence of five technologies in ACS and PPA: transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), transcranial random noise stimulation (tRNS), repetitive transcranial magnetic stimulation (rTMS), and noninvasive vagus nerve stimulation (nVNS). Many randomized controlled trials of tDCS and rTMS report positive treatment effects on cognition in ACS and PPA that persist out to at least 8 weeks, whereas there are few trials for tACS and none for tRNS and nVNS. However, most positive trials did not identify clinically meaningful changes, underscoring that clinical efficacy has yet to be established in ACS and PPA. Much is still to be learned about noninvasive brain stimulation in ACS and PPA, and shifting the focus to prioritize clinical significance in addition to statistical significance in trials could yield greater success in understanding its potential cognitive effects and optimal parameters.<\/jats:p>","DOI":"10.3233\/jad-240230","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T11:55:25Z","timestamp":1718970925000},"page":"743-760","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["A Critical Review of Noninvasive Brain Stimulation Technologies in Alzheimer\u2019s Dementia and Primary Progressive Aphasia"],"prefix":"10.1177","volume":"100","author":[{"given":"Christian","family":"LoBue","sequence":"first","affiliation":[{"name":"University of Texas Southwestern Medical Center","place":["USA"]},{"name":"University of Texas Southwestern Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shawn M.","family":"McClintock","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsueh-Sheng","family":"Chiang","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center","place":["USA"]},{"name":"University of Texas at Dallas","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica","family":"Helphrey","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vishal J.","family":"Thakkar","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hart","sequence":"additional","affiliation":[{"name":"University of Texas Southwestern Medical Center","place":["USA"]},{"name":"University of Texas Southwestern Medical Center","place":["USA"]},{"name":"University of Texas at Dallas","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,6,20]]},"reference":[{"key":"e_1_3_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_3_4_3_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31821103e6"},{"key":"e_1_3_4_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01403-0"},{"key":"e_1_3_4_5_2","doi-asserted-by":"publisher","DOI":"10.1017\/9781316996751.015"},{"key":"e_1_3_4_6_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617715000399"},{"key":"e_1_3_4_7_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.34"},{"key":"e_1_3_4_8_2","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.30"},{"key":"e_1_3_4_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01124-2"},{"key":"e_1_3_4_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature19323"},{"key":"e_1_3_4_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.3.317"},{"key":"e_1_3_4_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/09647040600630160"},{"key":"e_1_3_4_13_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1964.sp007425"},{"key":"e_1_3_4_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.11.1602"},{"key":"e_1_3_4_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/13554790601126203"},{"key":"e_1_3_4_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.06.015"},{"key":"e_1_3_4_17_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160571"},{"key":"e_1_3_4_18_2","first-page":"CD005562","article-title":"Cognitive stimulation to improve cognitive functioning in people with dementia","volume":"2","author":"Woods B","year":"2023","unstructured":"WoodsB, RaiHK, ElliottE, AguirreE, OrrellM, SpectorA (2023) Cognitive stimulation to improve cognitive functioning in people with dementia. Cochrane Database Syst Rev 2, CD005562.","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_3_4_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000464"},{"key":"e_1_3_4_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-022-01444-7"},{"key":"e_1_3_4_21_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205704"},{"key":"e_1_3_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.08.020"},{"key":"e_1_3_4_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000304"},{"key":"e_1_3_4_24_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-323870"},{"key":"e_1_3_4_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101499"},{"key":"e_1_3_4_26_2","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10090597"},{"key":"e_1_3_4_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.acn.2004.08.002"},{"key":"e_1_3_4_28_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-021-01228-7"},{"key":"e_1_3_4_29_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2017.00641"},{"key":"e_1_3_4_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2008.06.004"},{"key":"e_1_3_4_31_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1965.28.1.166"},{"key":"e_1_3_4_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2016.10.001"},{"key":"e_1_3_4_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2007.01.004"},{"key":"e_1_3_4_34_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000152986.07469.E9"},{"key":"e_1_3_4_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2017.10.020"},{"key":"e_1_3_4_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2016.06.004"},{"key":"e_1_3_4_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2011.02.007"},{"key":"e_1_3_4_38_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145710001690"},{"key":"e_1_3_4_39_2","doi-asserted-by":"publisher","DOI":"10.1177\/1545968319840285"},{"key":"e_1_3_4_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2019.06.003"},{"key":"e_1_3_4_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2022.11.009"},{"key":"e_1_3_4_42_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00275"},{"key":"e_1_3_4_43_2","doi-asserted-by":"publisher","DOI":"10.1136\/gpsych-2023-101166"},{"key":"e_1_3_4_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neucli.2022.02.003"},{"key":"e_1_3_4_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2011.06.006"},{"key":"e_1_3_4_46_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01231"},{"key":"e_1_3_4_47_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000317060.43722.a3"},{"key":"e_1_3_4_48_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-016-0180-3"},{"key":"e_1_3_4_49_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1327886"},{"key":"e_1_3_4_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.11.005"},{"key":"e_1_3_4_51_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-131427"},{"key":"e_1_3_4_52_2","doi-asserted-by":"publisher","DOI":"10.1080\/02687038.2014.930410"},{"key":"e_1_3_4_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.05.023"},{"key":"e_1_3_4_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2019.03.011"},{"key":"e_1_3_4_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2018.08.002"},{"key":"e_1_3_4_56_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2017.00347"},{"key":"e_1_3_4_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2017.03.003"},{"key":"e_1_3_4_58_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2019.01396"},{"key":"e_1_3_4_59_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2022.907425"},{"key":"e_1_3_4_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2009.03.005"},{"key":"e_1_3_4_61_2","doi-asserted-by":"publisher","DOI":"10.1088\/1741-2560\/8\/4\/046011"},{"key":"e_1_3_4_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2012.09.010"},{"key":"e_1_3_4_63_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210378"},{"key":"e_1_3_4_64_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2018.00211"},{"key":"e_1_3_4_65_2","doi-asserted-by":"publisher","DOI":"10.3233\/RNN-120297"},{"key":"e_1_3_4_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobeha.2021.01.003"},{"key":"e_1_3_4_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2020.101878"},{"key":"e_1_3_4_68_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2023.1146687"},{"key":"e_1_3_4_69_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2023.04.001"},{"key":"e_1_3_4_70_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11065-023-09589-0"},{"key":"e_1_3_4_71_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215072"},{"key":"e_1_3_4_72_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2023.1168673"},{"key":"e_1_3_4_73_2","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2021.632545"},{"key":"e_1_3_4_74_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-326885"},{"key":"e_1_3_4_75_2","first-page":"3649","article-title":"The effect of transcranial alternating current stimulation (tACS) on cognitive function in older adults with dementia","author":"Kehler L","year":"2020","unstructured":"KehlerL, FranciscoCO, UeharaMA, MoussaviZ (2020) The effect of transcranial alternating current stimulation (tACS) on cognitive function in older adults with dementia. Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC), pp. 3649\u20133653.","journal-title":"Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC)"},{"key":"e_1_3_4_76_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26411"},{"key":"e_1_3_4_77_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-023-01456-8"},{"key":"e_1_3_4_78_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-51553-7"},{"key":"e_1_3_4_79_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104702"},{"key":"e_1_3_4_80_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2961-20.2021"},{"key":"e_1_3_4_81_2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.625359"},{"key":"e_1_3_4_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2020.07.001"},{"key":"e_1_3_4_83_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4248-08.2008"},{"key":"e_1_3_4_84_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3248-18.2019"},{"key":"e_1_3_4_85_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4519-15.2016"},{"key":"e_1_3_4_86_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30261-3"},{"key":"e_1_3_4_87_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36011"},{"key":"e_1_3_4_88_2","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000110"},{"key":"e_1_3_4_89_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3263-16.2017"},{"key":"e_1_3_4_90_2","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2022.2170784"},{"key":"e_1_3_4_91_2","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12101617"},{"key":"e_1_3_4_92_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00668"},{"key":"e_1_3_4_93_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.06.026"},{"key":"e_1_3_4_94_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.11.002"},{"key":"e_1_3_4_95_2","unstructured":"FDAnews Brainsway\u2019s deep TMS H7 coil gets expanded 510(k) clearance https:\/\/www.fdanews.com\/articles\/209198-brainsways-deep-tms-h7-coil-gets-expanded-510k-clearance Last updated August 30 2022 Accessed on November 2 2023."},{"key":"e_1_3_4_96_2","unstructured":"Globe Newswire BrainsWay Receives FDA Clearance for Smoking Addiction in Adults https:\/\/www.globenewswire.com\/news-release\/2020\/08\/24\/2082476\/0\/en\/BrainsWay-Receives-FDA-Clearance-for-Smoking-Addiction-in-Adults.html Last updated August 24 2020 Accessed on November 2 2023."},{"key":"e_1_3_4_97_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0263145"},{"key":"e_1_3_4_98_2","doi-asserted-by":"publisher","DOI":"10.1177\/1039856217748249"},{"key":"e_1_3_4_99_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2022.06.038"},{"key":"e_1_3_4_100_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.06.067"},{"key":"e_1_3_4_101_2","first-page":"3651","article-title":"Consensus recommendations for the clinical application of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression","volume":"79","author":"McClintock SM","year":"2017","unstructured":"McClintockSM, RetiIM, CarpenterLL, McDonaldWM, DubinM, TaylorSF, CookIA, JohnO, HusainMM, WallC (2017) Consensus recommendations for the clinical application of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression. J Clin Psychiatry 79, 3651.","journal-title":"J Clin Psychiatry"},{"key":"e_1_3_4_102_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.03.016"},{"key":"e_1_3_4_103_2","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12946"},{"key":"e_1_3_4_104_2","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S276635"},{"key":"e_1_3_4_105_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150346"},{"key":"e_1_3_4_106_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150067"},{"key":"e_1_3_4_107_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-019-09644-y"},{"key":"e_1_3_4_108_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2022.114721"},{"key":"e_1_3_4_109_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhab371"},{"key":"e_1_3_4_110_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.08.036"},{"key":"e_1_3_4_111_2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac285"},{"key":"e_1_3_4_112_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2021.11.007"},{"key":"e_1_3_4_113_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2021.01.012"},{"key":"e_1_3_4_114_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2022.06.004"},{"key":"e_1_3_4_115_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-011-6128-4"},{"key":"e_1_3_4_116_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2009.197848"},{"key":"e_1_3_4_117_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2008.02202.x"},{"key":"e_1_3_4_118_2","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-210566"},{"key":"e_1_3_4_119_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617799555021"},{"key":"e_1_3_4_120_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-023-02594-w"},{"key":"e_1_3_4_121_2","doi-asserted-by":"publisher","DOI":"10.1111\/head.12647"},{"key":"e_1_3_4_122_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.02.023"},{"key":"e_1_3_4_123_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-25864-1"},{"key":"e_1_3_4_124_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2018.02.056"},{"key":"e_1_3_4_125_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2014.07.031"},{"key":"e_1_3_4_126_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00020"},{"key":"e_1_3_4_127_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.08.005"},{"key":"e_1_3_4_128_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2014.11.018"},{"key":"e_1_3_4_129_2","doi-asserted-by":"publisher","DOI":"10.1111\/ner.12541"},{"key":"e_1_3_4_130_2","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.064543"},{"key":"e_1_3_4_131_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n1103"},{"key":"e_1_3_4_132_2","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0801"},{"key":"e_1_3_4_133_2","doi-asserted-by":"publisher","DOI":"10.1038\/4600"},{"key":"e_1_3_4_134_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.wnn.0000213908.34278.7d"},{"key":"e_1_3_4_135_2","doi-asserted-by":"publisher","DOI":"10.1037\/neu0000735"},{"key":"e_1_3_4_136_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2020.10.012"},{"key":"e_1_3_4_137_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2022.114164"},{"key":"e_1_3_4_138_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-017-0411-2"},{"key":"e_1_3_4_139_2","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617799544068"},{"key":"e_1_3_4_140_2","doi-asserted-by":"publisher","DOI":"10.1037\/pas0001138"},{"key":"e_1_3_4_141_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01546-8"},{"key":"e_1_3_4_142_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brs.2020.02.011"},{"key":"e_1_3_4_143_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3360-1"},{"key":"e_1_3_4_144_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-023-01297-4"}],"container-title":["Journal of Alzheimer\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-240230","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JAD-240230","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JAD-240230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T17:49:05Z","timestamp":1780422545000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JAD-240230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,20]]},"references-count":143,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,7,30]]}},"alternative-id":["10.3233\/JAD-240230"],"URL":"https:\/\/doi.org\/10.3233\/jad-240230","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,20]]}}}