{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:35:29Z","timestamp":1779377729035,"version":"3.53.1"},"reference-count":53,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,7,16]]},"abstract":"<jats:p>Background: Traumatic brain injury (TBI) may confer risk for Alzheimer\u2019s disease (AD) through amyloid-\u03b2 (A\u03b2) overproduction. However, the relationship between TBI and A\u03b2 levels in cerebrospinal fluid (CSF) remains unclear. Objective: To explore whether A\u03b2 overproduction is implicated in the relationship between TBI and AD, we compared CSF levels of A\u03b2 in individuals with a TBI history versus controls (CTRLs) and related CSF A\u03b2 levels to cognitive markers associated with preclinical AD. Methods: Participants were 112 non-impaired Veterans (TBI\u200a=\u200a56, CTRL\u200a=\u200a56) from the Alzheimer\u2019s Disease Neuroimaging Initiative-Department of Defense database with available cognitive data (Boston Naming Test [BNT], Rey Auditory Verbal Learning Test [AVLT]) and CSF measures of A\u03b242, A\u03b240, and A\u03b238. Mediation models explored relationships between TBI history and BNT scores with A\u03b2 peptides as mediators. Results: The TBI group had higher CSF A\u03b240 (t\u200a=\u200a\u20132.43, p\u200a=\u200a0.017) and A\u03b238 (t\u200a=\u200a\u20132.10, p\u200a=\u200a0.038) levels than the CTRL group, but groups did not differ in CSF A\u03b242 levels or A\u03b242\/A\u03b240 ratios (p\u200a&gt;\u200a0.05). Both A\u03b2 peptides negatively correlated with BNT (A\u03b240: rho\u200a=\u200a\u20130.20, p\u200a=\u200a0.032; A\u03b238: rho\u200a=\u200a\u20130.19, p\u200a=\u200a0.048) but not AVLT (p\u200a&gt;\u200a0.05). A\u03b240 had a significant indirect effect on the relationship between TBI and BNT performance (\u03b2=\u200a\u20130.16, 95% CI [\u20130.393, \u20130.004], PM\u200a=\u200a0.54). Conclusions: TBI may increase AD risk and cognitive vulnerability through A\u03b2 overproduction. Biomarker models incorporating multiple A\u03b2 peptides may help identify AD risk among those with TBI.<\/jats:p>","DOI":"10.3233\/jad-240254","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T13:51:01Z","timestamp":1719582661000},"page":"539-550","source":"Crossref","is-referenced-by-count":2,"title":["Higher Cerebrospinal Fluid Levels of Amyloid-\u03b240 Following Traumatic Brain Injury Relate to Confrontation Naming Performance"],"prefix":"10.1177","volume":"100","author":[{"given":"Erica","family":"Howard","sequence":"first","affiliation":[{"name":"Psychology Department, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jena N.","family":"Moody","sequence":"additional","affiliation":[{"name":"Psychology Department, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Prieto","sequence":"additional","affiliation":[{"name":"Psychology Department, The Ohio State University, Columbus, OH, USA"},{"name":"Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University, Providence, RI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmeet P.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Psychology Department, The Ohio State University, Columbus, OH, USA"},{"name":"Chronic Brain Injury Initiative, The Ohio State University, Columbus, OH, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-240254_ref1","first-page":"327","article-title":"Alzheimer\u2019s disease facts and figures","volume":"17","author":"Alzheimer\u2019s Association","year":"2021","journal-title":"Alzheimers 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