{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:19:17Z","timestamp":1777393157106,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,9,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The relationship between young-onset dementia and peripheral vestibular disorders remained largely unknown although this association was observed in the older population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>This case-control study aims to investigate the association of young-onset dementia with a pre-existing diagnosis of peripheral vestibular disorders using a population-based data from Taiwan\u2019s Longitudinal Health Insurance Database 2010.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This study included 989 patients with young-onset dementia and 2967 propensity-score-matching controls. Differences in baseline characteristic between patients with young-onset dementia and controls were investigated using chi-square tests or t-tests. Multiple logistic regression models were employed to assess the association of young-onset dementia (outcome) with pre-existing peripheral vestibular disorders (predictor).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Compared to patients without young-onset dementia, those affected by this condition exhibited a statistically significantly higher rate of peripheral vestibular disorders (18.3% versus 8.2%, p\u200a&lt;\u200a0.001). Furthermore, our analysis found notable between-group disparities in the rates of Meniere\u2019s Disease (3.5% versus 2.0%, p=\u200a0.015), benign paroxysmal positional vertigo (2.4% versus 1.1%, p=\u200a0.006), and vestibular neuritis (2.4% versus 1.1%, p=\u200a0.003). Multiple logistic regression analysis showed that the presence of prior peripheral vestibular disorders increased the odds of young-onset dementia [2.603 (95% CI\u200a=\u200a2.105\u223c3.220)] after adjusting for age, sex, monthly income, geographic location, urbanization level, hyperlipidemia, diabetes, coronary heart disease, hearing loss, and hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The study findings demonstrate a notable association between young-onset dementia and pre-existing peripheral vestibular disorders, suggesting that vestibular malfunction could play a role in the development of young-onset dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-240309","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T10:08:55Z","timestamp":1724753335000},"page":"603-610","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of Young-Onset Dementia with Pre-Existing Peripheral Vestibular Disorders"],"prefix":"10.1177","volume":"101","author":[{"given":"Shih-Han","family":"Hung","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, School of Medicine, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Otolaryngology, Wan Fang Hospital, Taipei, Taiwan"},{"name":"International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alison H.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy and Human Movement Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Fu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, Taipei Veterans General Hospital, Taipei, Taiwan"},{"name":"Department of Otolaryngology-Head and Neck Surgery, School of Medicine, National Yang Ming Chiao Tung University, Hsinchu City, Taiwan"},{"name":"Research Center of Data Science on Healthcare Industry, College of Management, Taipei Medical University, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herng-Ching","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Health Care Administration, College of Management, Taipei Medical University, Taipei, Taiwan"},{"name":"Research Center of Sleep Medicine, Taipei Medical University Hospital, Taipei, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin-Shyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Research Center of Data Science on Healthcare Industry, College of Management, Taipei Medical University, Taipei, Taiwan"},{"name":"Department of Economics, National Taipei University, New Taipei City, 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