{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:04:52Z","timestamp":1787025892851,"version":"build-2736575974"},"reference-count":50,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T00:00:00Z","timestamp":1721088000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,7,30]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Higher midlife physical activity engagement has been associated with lower dementia risk in late life. However, the underlying mechanisms contributing to the protective effect remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The goal of the current study was to evaluate the associations of physical activity with cerebral amyloid-\u03b2 (A\u03b2) and tau in a predominately middle-aged community-based cohort, as well as to explore whether the associations differ by sex or age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>\n                      Participants from the Framingham Heart Study underwent\n                      <jats:sup>11<\/jats:sup>\n                      C-Pittsburgh Compound B amyloid and\n                      <jats:sup>18<\/jats:sup>\n                      F-Flortaucipir tau positron emission tomography (PET) imaging. Total physical activity levels were evaluated by self-report using the Physical Activity Index (PAI). Cross-sectional associations between total PAI with regional A\u03b2 and tau PET retention were evaluated using linear regression models adjusted for demographic and cardiovascular risk factors. Interactions with sex and age group were examined and stratified analyses were performed when significant. FDR-correction for multiple comparisons was applied.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The sample included 354 participants (mean age 53\u00b18 years, 51% female). Higher total PAI scores were associated with lower entorhinal cortex tau PET binding (\u03b2\u00a0(SE)\u200a=\u200a\u20130.021(0.008),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.049). There were significant interactions with sex. In men alone, total PAI inversely associated with entorhinal cortex (\u03b2\u00a0(SE)\u200a=\u200a\u20130.035(0.009),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.001), inferior temporal (\u03b2\u00a0(SE)\u200a=\u200a\u20130.029(0.010),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.012), and rhinal cortex tau(\u03b2\u00a0(SE)\u200a=\u200a\u20130.033(0.010),\n                      <jats:italic toggle=\"yes\">p<\/jats:italic>\n                      \u200a=\u200a0.002).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The results suggest that higher midlife physical activity engagement may confer resistance to tau pathology. However, the effects may vary based on sex, highlighting the importance of better understanding and tailoring lifestyle interventions to address sex disparities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-240322","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T11:50:24Z","timestamp":1721389824000},"page":"935-943","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Associations of Physical Activity Engagement with Cerebral Amyloid-\u03b2 and Tau from Midlife"],"prefix":"10.1177","volume":"100","author":[{"given":"Mitzi M.","family":"Gonzales","sequence":"first","affiliation":[{"name":"Cedars Sinai Medical Center","place":["USA"]},{"name":"University of Texas Health Science Center at San Antonio","place":["USA"]},{"name":"University of Texas Health Science Center at San 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Davis","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges","family":"El Fakhri","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School","place":["USA"]},{"name":"Yale University","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Massachusetts General Hospital and Harvard Medical School","place":["USA"]},{"name":"Massachusetts General Hospital and Harvard Medical School","place":["USA"]},{"name":"Brigham and Women\u2019s Hospital and Harvard Medical School","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexa S.","family":"Beiser","sequence":"additional","affiliation":[{"name":"The Framingham Heart Study","place":["USA"]},{"name":"Boston University School of Public Health","place":["USA"]},{"name":"Boston University School of 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