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The abundance of A\u03b2 in the aging primate brain is well tolerated, and the impact on cognitive functions is usually limited to particular tasks. In contrast, human brain aging is characterized by the early appearance of HPtau pathology, mainly forming neurofibrillary tangles, dystrophic neurites of neuritic plaques, and neuropil threads, preceding A\u03b2 deposits by several decades and by its severity progressing from selected nuclei of the brain stem, entorhinal cortex, and hippocampus to the limbic system, neocortex, and other brain regions. Neurofibrillary tangles correlate with cognitive impairment and dementia in advanced cases. A\u03b2 pathology is linked in humans to altered membrane protein and lipid composition, particularly involving lipid rafts. Although similar membrane alterations are unknown in non-human primates, membrane senescence is postulated to cause the activated \u03b2-amyloidogenic pathway, and A\u03b2 pathology is the prevailing signature of non-human and human primate brain aging.<\/jats:p>","DOI":"10.3233\/jad-240389","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T11:50:36Z","timestamp":1721389836000},"page":"S153-S164","source":"Crossref","is-referenced-by-count":5,"title":["Amyloid-\u03b2 Pathology Is the Common Nominator Proteinopathy of the Primate Brain Aging"],"prefix":"10.1177","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9888-8754","authenticated-orcid":false,"given":"Isidro","family":"Ferrer","sequence":"first","affiliation":[{"name":"Department of Pathology and Experimental Therapeutics, University of Barcelona, Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-240389_ref1","first-page":"445","article-title":"Sur les l\u00e9sions et la pathog\u00e9nie de l\u2019\u00e9pilepsie dite essentielle","volume":"12","author":"Blocq","year":"1892","journal-title":"Sem M\u00e9d"},{"key":"10.3233\/JAD-240389_ref2","first-page":"208","article-title":"Uber miliare Sklerose der Hirnrinde bei seniler Atrophie","volume":"17","author":"Redlich","year":"1898","journal-title":"Jahrb Psychiat Neurol"},{"key":"10.3233\/JAD-240389_ref3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1159\/000211873","article-title":"Miliare Nekrosen mit drusigen Wucherungen der Neurofibrillen, eine regelm\u00e4ssige Ver\u00e4nderung der Hirnrinde bei seniler Demenz","volume":"22","author":"Fischer","year":"1907","journal-title":"Monatsschr Psychiat Neurol"},{"key":"10.3233\/JAD-240389_ref4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/BF02893605","article-title":"Die presbyophrene Demenz, deren anatomische Grundlage und klinische Abgrenzung","volume":"3","author":"Fischer","year":"1910","journal-title":"Z Ges Neurol Psychiatr"},{"key":"10.3233\/JAD-240389_ref5","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF02866372","article-title":"Ein weiterer Beitrag zur Klinik und Pathologie der presbyophrenen Demenz","volume":"12","author":"Fischer","year":"1912","journal-title":"Z Ges Neurol Psychiatr"},{"key":"10.3233\/JAD-240389_ref6","first-page":"267","article-title":"Histologische Studien uber die senile demenz","author":"Simchowitz","year":"1911","journal-title":"Histologische und Histopathologische Arbeiten \u00fcber die Grosshirnrindem"},{"key":"10.3233\/JAD-240389_ref7","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1093\/brain\/awn256","article-title":"Oskar Fischer and the study of dementia","volume":"132","author":"Goedert","year":"2009","journal-title":"Brain"},{"key":"10.3233\/JAD-240389_ref8","first-page":"146","article-title":"\u00dcber eine eigenartige Erkrankung der Hirnrinde","volume":"64","author":"Alzheimer","year":"1907","journal-title":"Allg Z Psychiat"},{"key":"10.3233\/JAD-240389_ref9","unstructured":"Kraepelin E . 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