{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T05:34:06Z","timestamp":1782970446479,"version":"3.54.5"},"reference-count":33,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,9,10]]},"abstract":"<jats:p>Reduced functional magnetic resonance imaging (fMRI)-complexity in Alzheimer\u2019s disease (AD) progression has been demonstrated and found to be associated with tauopathy and cognition. However, association of fMRI-complexity with amyloid and influence of genetic risk ( APOE \u025b4) remain unknown. Here we investigate the association between fMRI-complexity, tau-PET, and amyloid-PET as well as influence of APOE genotype using multivariate generalized linear models. We show that fMRI-complexity has a strong association with tau but not amyloid deposition and that the presence of an APOE \u025b4 allele enhances this effect. Thus fMRI-complexity provides a surrogate marker of impaired brain functionality in AD progression.<\/jats:p>","DOI":"10.3233\/jad-240459","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T11:24:23Z","timestamp":1724412263000},"page":"429-435","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Genetic Risk on the Relationship Between rs-fMRI Complexity and Tau and Amyloid PET in Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"101","author":[{"given":"Kay","family":"Jann","sequence":"first","affiliation":[{"name":"USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Cen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariella","family":"Santos","sequence":"additional","affiliation":[{"name":"USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Aksman","sequence":"additional","affiliation":[{"name":"USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilmini","family":"Wijesinghe","sequence":"additional","affiliation":[{"name":"USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru","family":"Zhang","sequence":"additional","affiliation":[{"name":"USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Lynch","sequence":"additional","affiliation":[{"name":"USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Ringman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny J.","family":"Wang","sequence":"additional","affiliation":[{"name":"USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer\u2019s Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,2,5]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2014.00409"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1007\/s11682-013-9276-6"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00352"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0089948"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.03.015"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.3390\/e22020239"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2012.05.001"},{"key":"ref008","doi-asserted-by":"crossref","unstructured":"RichmanJS and MoormanJR. 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