{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T22:41:32Z","timestamp":1780094492556,"version":"3.54.0"},"reference-count":150,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,10,8]]},"abstract":"<jats:p>Background: Neuropathologic studies of brains from autopsy series show tau inclusions (pretangles, neuropils threads, neurofibrillary tangles) are detectable more than a decade before amyloid-\u03b2 (A\u03b2) deposition in Alzheimer\u2019s disease (AD) and develop in a characteristic manner that forms the basis for AD staging. An alternative position views pathological tau without A\u03b2 deposition as a \u2018primary age-related tauopathy\u2019 (PART) rather than prodromal AD. Recently, an early focus of tau inclusions in the Ammon\u2019s horn second sector (CA2) with relative sparing of CA1 that occurs before tau inclusions develop in the entorhinal cortex (EC) was proposed as an additional feature of PART. Objective: To test the \u2018definite PART\u2019 hypothesis. Methods: We used AT8-immunohistochemistry in 100\u03bcm sections to examine the EC, transentorhinal cortex (TRE), and Ammon\u2019s horn in 325 brains with tau inclusions lacking A\u03b2 deposits (average age at death 66.7 years for females, 66.4 years for males). Results: 100% of cases displayed tau inclusions in the TRE. In 89% of cases, the CA1 tau rating was greater than or equal to that in CA2. In 25%, CA2 was devoid of tau inclusions. Only 4% displayed a higher tau score in CA2 than in the TRE, EC, and CA1. The perforant path also displayed early tau changes. APOE genotyping was available for 199\/325 individuals. Of these, 44% had an \u025b4 allele that placed them at greater risk for developing later NFT stages and, therefore, clinical AD. Conclusions: Our new findings call into question the PART hypothesis and are consistent with the idea that our cases represent prodromal AD.<\/jats:p>","DOI":"10.3233\/jad-240483","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T10:35:34Z","timestamp":1726828534000},"page":"1333-1353","source":"Crossref","is-referenced-by-count":10,"title":["Early CA2 Tau Inclusions Do Not Distinguish an Age-Related Tauopathy from Early Alzheimer\u2019s Disease"],"prefix":"10.1177","volume":"101","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9130-7838","authenticated-orcid":false,"given":"Kelly","family":"Del Tredici","sequence":"first","affiliation":[{"name":"Clinical Neuroanatomy\/Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Sch\u00f6n","sequence":"additional","affiliation":[{"name":"Institute for Anatomy and Cell Biology, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Feldengut","sequence":"additional","affiliation":[{"name":"Clinical Neuroanatomy\/Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estifanos","family":"Ghebremedhin","sequence":"additional","affiliation":[{"name":"Institute of Clinical Neuroanatomy, Goethe University Frankfurt, Frankfurt am Main, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah K.","family":"Kaufman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Memory and Aging Center, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Wiesner","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University, Ulm, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Roselli","sequence":"additional","affiliation":[{"name":"Department of Neurology, Ulm University, Ulm, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Mayer","sequence":"additional","affiliation":[{"name":"Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin","family":"Amunts","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience and Medicine (INM-1), Research Center J\u00fclich, J\u00fclich, Germany"},{"name":"C\u00e9cile and Oskar Vogt Institute for Brain Research, University Hospital D\u00fcsseldorf, Heinrich Heine University D\u00fcsseldorf, D\u00fcsseldorf, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Braak","sequence":"additional","affiliation":[{"name":"Clinical Neuroanatomy\/Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-240483_ref1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological stageing of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref2","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1177\/002215540004801206","article-title":"Novel method to quantify neuropil threads in brains from elders with or without cognitive impairment","volume":"48","author":"Mitchell","year":"2000","journal-title":"J Histochem Cytochem"},{"key":"10.3233\/JAD-240483_ref3","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jalz.2011.10.007","article-title":"National Institute on Aging-Alzheimer\u2019s association guidelines for the neuropathologic assessment of Alzheimer\u2019s disease","volume":"8","author":"Hyman","year":"2012","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-240483_ref5","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1097\/NEN.0b013e318232a379","article-title":"Stages of the pathologic process in Alzheimer disease: age categories from 1 to 100 years","volume":"70","author":"Braak","year":"2011","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-240483_ref6","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1093\/brain\/awv236","article-title":"The preclinical phase of the pathological process underlying sporadic Alzheimer\u2019s disease","volume":"138","author":"Braak","year":"2015","journal-title":"Brain"},{"key":"10.3233\/JAD-240483_ref7","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1093\/jnen\/nlz123","article-title":"From the entorhinal region via the prosubiculum to the dentate fascia: Alzheimer disease-related neurofibrillary changes in the temporal allocortex","volume":"79","author":"Braak","year":"2020","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-240483_ref8","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1212\/WNL.42.3.631","article-title":"Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer\u2019s disease","volume":"42","author":"Arriagada","year":"1992","journal-title":"Neurology"},{"key":"10.3233\/JAD-240483_ref9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1001\/archneur.1995.00540250089017","article-title":"Neocortical neurofibrillary tangles correlate with dementia severity in Alzheimer\u2019s disease","volume":"52","author":"Bierer","year":"1995","journal-title":"Arch Neurol"},{"key":"10.3233\/JAD-240483_ref10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0197-4580(99)00063-9","article-title":"Memory and mental status correlates of modified Braak staging","volume":"20","author":"Grober","year":"1999","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-240483_ref11","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/jnen\/60.10.946","article-title":"Clinical validity of A beta-protein deposition staging in brain aging and Alzheimer disease","volume":"60","author":"Gold","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-240483_ref12","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1212\/01.WNL.0000063311.58879.01","article-title":"Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer\u2019s disease","volume":"60","author":"Giannakopoulos","year":"2003","journal-title":"Neurology"},{"key":"10.3233\/JAD-240483_ref13","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1093\/jnen\/nlw026","article-title":"Thal amyloid stages do not significantly impact the correlation between neuropathological change and cognition in the Alzheimer disease continuum","volume":"75","author":"Serrano-Pozo","year":"2016","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-240483_ref14","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/s41591-020-0938-9","article-title":"Tau molecular diversity contributes to clinical heterogeneity in Alzheimer\u2019s disease","volume":"26","author":"Dujardin","year":"2020","journal-title":"Nat Med"},{"key":"10.3233\/JAD-240483_ref15","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1093\/jnen\/nlaa153","article-title":"Early selective vulnerability of the CA2 hippocampal subfield in primary age-related tauopathy","volume":"80","author":"Walker","year":"2021","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-240483_ref16","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s00401-015-1390-7","article-title":"PART is part of Alzheimer disease","volume":"129","author":"Duyckaerts","year":"2015","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref17","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/bpa.12919","article-title":"Primary age-related tauopathy (PART) in the general autopsy setting: Not just a disease of the elderly","volume":"31","author":"Humphrey","year":"2021","journal-title":"Brain Pathol"},{"key":"10.3233\/JAD-240483_ref18","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1001\/jama.1997.03550160069041","article-title":"Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium","volume":"278","author":"Farrer","year":"1997","journal-title":"JAMA"},{"key":"10.3233\/JAD-240483_ref19","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/hmg\/3.4.569","article-title":"Apolipoprotein E, epsilon 4 allele as a major risk factor for sporadic early and late-onset forms of Alzheimer\u2019s disease: analysis of the 19q13.2 chromosomal region","volume":"3","author":"Chartier-Harlin","year":"1994","journal-title":"Hum Mol Genet"},{"key":"10.3233\/JAD-240483_ref20","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng0694-180","article-title":"Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease","volume":"7","author":"Corder","year":"1994","journal-title":"Nat Genet"},{"key":"10.3233\/JAD-240483_ref21","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E and type 4 allele and the risk of Alzheimer\u2019s disease in late-onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.3233\/JAD-240483_ref22","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/0140-6736(93)91705-Q","article-title":"Apolipoprotein E polymorphism and Alzheimer\u2019s disease","volume":"342","author":"Poirier","year":"1993","journal-title":"Lancet"},{"key":"10.3233\/JAD-240483_ref23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000334607","article-title":"Prevalence of apolipoprotein E4 genotype and homozygotes (APOE e4\/4) among patients diagnosed with Alzheimer\u2019s disease: a systematic review and metaanalysis","volume":"38","author":"Ward","year":"2012","journal-title":"Neuroepidemiology"},{"key":"10.3233\/JAD-240483_ref24","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1038\/nature24016","article-title":"ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy","volume":"549","author":"Shi","year":"2017","journal-title":"Nature"},{"key":"10.3233\/JAD-240483_ref25","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1002\/mds.20663","article-title":"Presence of an APOE4 allele results in significantly earlier onset of Parkinson\u2019s disease and a higher risk with dementia","volume":"21","author":"Pankratz","year":"2006","journal-title":"Mov Disord"},{"key":"10.3233\/JAD-240483_ref26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1001\/jamaneurol.2013.600","article-title":"APOE \u025b4 increases risk for dementia in pure synucleinopathies","volume":"70","author":"Tsuang","year":"2013","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-240483_ref27","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1001\/jamaneurol.2015.0606","article-title":"Clinical features of Alzheimer disease with and without Lewy bodies","volume":"72","author":"Chung","year":"2015","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-240483_ref28","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1001\/jamaneurol.2018.3139","article-title":"Association of apolipoprotein E \u025b4 with transactive response DNA-binding protein 43","volume":"75","author":"Wenneberg","year":"2018","journal-title":"JAMA Neurol"},{"key":"10.3233\/JAD-240483_ref29","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S1474-4422(18)30251-5","article-title":"Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE \u025b4 haplotype status: a community-based cohort study","volume":"17","author":"Yang","year":"2018","journal-title":"Lancet Neurol"},{"key":"10.3233\/JAD-240483_ref30","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/nrneurol.2012.263","article-title":"Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy","volume":"9","author":"Liu","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"10.3233\/JAD-240483_ref31","doi-asserted-by":"crossref","first-page":"e1002254","DOI":"10.1371\/journal.pmed.1002254","article-title":"APOE-related risk of mild cognitive impairment and dementia for prevention trials: An analysis of four cohorts","volume":"14","author":"Qian","year":"2017","journal-title":"PLoS Med"},{"key":"10.3233\/JAD-240483_ref32","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1016\/j.neuron.2019.01.056","article-title":"A quarter century of APOE and Alzheimer\u2019s disease: progress to date and the path forward","volume":"101","author":"Belloy","year":"2019","journal-title":"Neuron"},{"key":"10.3233\/JAD-240483_ref33","doi-asserted-by":"crossref","first-page":"e2127","DOI":"10.1212\/WNL.0000000000005677","article-title":"APOE \u025b2\u025b4 genotype, incident AD and MCI, cognitive decline, and AD pathology in older adults","volume":"90","author":"Oveisgharan","year":"2018","journal-title":"Neurology"},{"key":"10.3233\/JAD-240483_ref34","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/NEN.0b013e31817275c7","article-title":"Accumulation of aspartic acid421- and glutamic acid391-cleaved tau in neurofibrillary tangles correlates with progression in Alzheimer disease","volume":"67","author":"Basurto-Islas","year":"2008","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-240483_ref35","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1002\/cne.25466","article-title":"Oligomeric, phosphorylated, and truncated tau and spliceosome pathology within the entorhinal-hippocampal connectome across stages of Alzheimer\u2019s disease","volume":"531","author":"Mahady","year":"2023","journal-title":"J Comp Neurol"},{"key":"10.3233\/JAD-240483_ref36","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1006\/exnr.1998.6860","article-title":"High frequency of apolipoprotein E \u025b4 allele in young individuals with very mild Alzheimer\u2019s disease-related neurofibrillary changes","volume":"155","author":"Ghebremedhin","year":"1998","journal-title":"Exp Neurol"},{"key":"10.3233\/JAD-240483_ref37","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00401-014-1349-0","article-title":"Primary age-related tauopathy (PART): a common pathology associated with human aging","volume":"128","author":"Crary","year":"2014","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref38","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1111\/j.1750-3639.2008.00147.x","article-title":"Staging of neurofibrillary pathology in Alzheimer\u2019s disease: A study of the BrainNet Europe Consortium","volume":"18","author":"Alafuzoff","year":"2008","journal-title":"Brain Pathol"},{"key":"10.3233\/JAD-240483_ref39","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3233\/JAD-150494","article-title":"To stage Alzheimer\u2019s disease related neurodegeneration using one section of hippocampus","volume":"48","author":"Popova","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-240483_ref40","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1056\/NEJMoa1703784","article-title":"Histopathological findings in brain tissue obtained during epilepsy surgery","volume":"377","author":"Bl\u00fcmcke","year":"2017","journal-title":"N Eng J Med"},{"key":"10.3233\/JAD-240483_ref41","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/ana.24388","article-title":"Hippocampal sclerosis and TDP-43 pathology in aging and Alzheimer disease","volume":"77","author":"Nag","year":"2015","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-240483_ref42","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/ana.25344","article-title":"Relative neuron loss in hippocampal sclerosis of aging and Alzheimer\u2019s disease","volume":"84","author":"Ihara","year":"2018","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-240483_ref43","first-page":"92:e831","article-title":"Postmortem neurodegenerative markers and trajectories of decline in cognitive systems","volume":"19","author":"Wilson","year":"2019","journal-title":"Neurology"},{"key":"10.3233\/JAD-240483_ref44","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s40478-021-01233-3","article-title":"Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study","volume":"9","author":"Iida","year":"2021","journal-title":"Acta Neuropathol Commun"},{"key":"10.3233\/JAD-240483_ref45","doi-asserted-by":"crossref","unstructured":"Ghetti BM , Buratti E , Boeve BM , et al. Frontotemporal Dementias: Emerging Milestones of the 21st Century. Cham, Switzerland: Springer, 2021.","DOI":"10.1007\/978-3-030-51140-1"},{"key":"10.3233\/JAD-240483_ref46","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0304-3940(87)90204-7","article-title":"Argyrophilic grains: characteristic pathology of cerebral cortex in cases of adult onset dementia without Alzheimer changes","volume":"76","author":"Braak","year":"1987","journal-title":"Neurosci Lett"},{"key":"10.3233\/JAD-240483_ref47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/brain\/aws307","article-title":"The spectrum of disease in chronic traumatic encephalopathy","volume":"136","author":"McKee","year":"2013","journal-title":"Brain"},{"key":"10.3233\/JAD-240483_ref48","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1038\/s41586-019-1026-5","article-title":"Novel tau filament fold in chronic traumatic encephalopathy encloses hydrophobic molecules","volume":"568","author":"Falcon","year":"2019","journal-title":"Nature"},{"key":"10.3233\/JAD-240483_ref49","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1097\/00005072-197911000-00006","article-title":"Topography of Pick inclusion bodies in hippocampi of demented patients. A quantitative study","volume":"38","author":"Ball","year":"1979","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-240483_ref50","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/BF00296179","article-title":"Quantitative neuropathologic analysis of Pick\u2019s disease cases: cortical distribution of Pick bodies and coexistence with Alzheimer\u2019s disease","volume":"87","author":"Hof","year":"1994","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref51","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF00296194","article-title":"Quantitative neuropathologic analysis of Pick\u2019s disease cases","volume":"87","author":"Jellinger","year":"1994","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref52","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41586-018-0454-y","article-title":"Structures of filaments from Pick\u2019s disease reveal a novel tau protein fold","volume":"561","author":"Falcon","year":"2018","journal-title":"Nature"},{"issue":"Pt A","key":"10.3233\/JAD-240483_ref53","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.nbd.2014.05.033","article-title":"Bidirectional links between Alzheimer\u2019s disease and Niemann-Pick type C disease","volume":"72","author":"Malnar","year":"2014","journal-title":"Neurobiol Dis"},{"key":"10.3233\/JAD-240483_ref54","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s40478-023-01565-2","article-title":"Identical tau filaments in subacute sclerosing panencephalitis and chronic traumatic encephalopathy","volume":"11","author":"Qi","year":"2023","journal-title":"Acta Neuropathol Commun"},{"key":"10.3233\/JAD-240483_ref55","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s00401-020-02158-2","article-title":"Distribution patterns of tau pathology in progressive supranuclear palsy","volume":"140","author":"Kovacs","year":"2020","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref56","first-page":"1","article-title":"Neuropathology of non-Alzheimer degenerative disorders","volume":"25","author":"Dickson","year":"2009","journal-title":"Int J Clin Exp Pathol"},{"key":"10.3233\/JAD-240483_ref57","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/ana.22424","article-title":"Clinicopathological correlations in corticobasal degeneration","volume":"70","author":"Lee","year":"2011","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-240483_ref58","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41586-020-2043-0","article-title":"Novel tau filament fold in corticobasal degeneration","volume":"580","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"10.3233\/JAD-240483_ref59","doi-asserted-by":"crossref","first-page":"e13250","DOI":"10.1111\/bpa.13250","article-title":"Huntingtin CAG repeats in neuropathologically confirmed tauopathies: Novel insights","author":"P\u00e9rez-Oliveira","year":"2024","journal-title":"Brain Pathol"},{"key":"10.3233\/JAD-240483_ref60","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.seizure.2018.03.014","article-title":"Epilepsy in neuropathologically verified Alzheimer\u2019s disease","volume":"58","author":"Rauramaa","year":"2018","journal-title":"Seizure"},{"key":"10.3233\/JAD-240483_ref61","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/1741-7015-8-68","article-title":"European Task Force on Disorders of Consciousness. Unresponsive wakefulness syndrome: a new name for the vegetative state or apallic syndrome","volume":"8","author":"Laureys","year":"2010","journal-title":"BMC Med"},{"key":"10.3233\/JAD-240483_ref62","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00401-015-1509-x","article-title":"Aging-related tau astrogliopathy (ARTAG): harmonized evaluation strategy","volume":"131","author":"Kovacs","year":"2016","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref63","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/j.1750-3639.1991.tb00661.x","article-title":"Demonstration of amyloid deposits and neurofibrillary changes in whole brain sections","volume":"1","author":"Braak","year":"1991","journal-title":"Brain Pathol"},{"key":"10.3233\/JAD-240483_ref64","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.neuroimage.2015.01.004","article-title":"Quantitative comparison of 21 protocols for labeling hippocampal subfields and parahippocampal subregions in in vivo MRI: towards a harmonized segmentation protocol","volume":"111","author":"Yushkevich","year":"2015","journal-title":"Neuroimage"},{"key":"10.3233\/JAD-240483_ref65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/hipo.22671","article-title":"A harmonized segmentation protocol for hippocampal and parahippocampal subregions: Why do we need one and what are the key goals?","volume":"27","author":"Wisse","year":"2017","journal-title":"Hippocampus"},{"key":"10.3233\/JAD-240483_ref66","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00429-019-02022-4","article-title":"Multimodal mapping and analysis of the cyto- and receptorarchitecture of the human hippocampus","volume":"225","author":"Palomero-Gallagher","year":"2020","journal-title":"Brain Struct Funct"},{"key":"10.3233\/JAD-240483_ref67","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00429-005-0025-5","article-title":"Cytoarchitectonic mapping of the human amygdala, hippocampal region and entorhinal cortex: intersubject variability and probability maps","volume":"210","author":"Amunts","year":"2005","journal-title":"Anat Embryol"},{"key":"10.3233\/JAD-240483_ref68","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s004010050622","article-title":"Alzheimer\u2019s disease: transiently developing dendritic changes in pyramidal cells of sector CA1 of the Ammon\u2019s horn","volume":"93","author":"Braak","year":"1997","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref69","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1126\/science.410102","article-title":"Hippocampal efferents reach widespread areas of cerebral cortex and amygdala in the rhesus monkey","volume":"198","author":"Rosene","year":"1977","journal-title":"Science"},{"key":"10.3233\/JAD-240483_ref70","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1007\/s00441-018-2848-4","article-title":"Routes to, from and within the subiculum","volume":"373","author":"B\u00f6hm","year":"2018","journal-title":"Cell Tissue Res"},{"key":"10.3233\/JAD-240483_ref71","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0006-8993(75)90206-1","article-title":"Some connections of the entorhinal (area 28) and perirhinal (area 35) cortices of the rhesus monkey. III. Efferent connections","volume":"95","author":"Van Hoesen","year":"1975","journal-title":"Brain Res"},{"key":"10.3233\/JAD-240483_ref72","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/B978-0-12-374236-0.10024-0","article-title":"Hippocampal formation","author":"Insausti","year":"2012","journal-title":"The Human Nervous System"},{"key":"10.3233\/JAD-240483_ref73","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00401-018-1894-z","article-title":"Different patterns of hippocampal tau pathology in Alzheimer\u2019s disease and PART","volume":"136","author":"Jellinger","year":"2018","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref74","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/cne.901890402","article-title":"Subcortical afferents to the hippocampal formation in the monkey","volume":"189","author":"Amaral","year":"1980","journal-title":"J Comp Neurol"},{"key":"10.3233\/JAD-240483_ref75","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/bs.pbr.2015.03.008","article-title":"Major diencephalic inputs to the hippocampus: supramammillary nucleus and nucleus reuniens. Circuitry and function","volume":"219","author":"Vertes","year":"2015","journal-title":"Prog Brain Res"},{"key":"10.3233\/JAD-240483_ref76","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0079-6123(08)61268-6","article-title":"Hippocampal formation: anatomy and the patterns of pathology in Alzheimer\u2019s disease","volume":"83","author":"Van Hoesen","year":"1990","journal-title":"Prog Brain Res"},{"key":"10.3233\/JAD-240483_ref77","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/cne.903070308","article-title":"Entorhinal cortex of the monkey: V. Projections to the dentate gyrus, hippocampus, and subicular complex","volume":"307","author":"Witter","year":"1991","journal-title":"J Comp Neurol"},{"key":"10.3233\/JAD-240483_ref78","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/WNR.0b013e328333d690","article-title":"Stratum radiatum of CA2 is an additional target of the perforant path in humans and monkeys","volume":"21","author":"Ding","year":"2010","journal-title":"Neuroreport"},{"key":"10.3233\/JAD-240483_ref79","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/hipo.450040316","article-title":"Principal cells are the postsynaptic targets of supramammillary afferents in the hippocampus of the rat","volume":"4","author":"Magl\u00f3czky","year":"1994","journal-title":"Hippocampus"},{"key":"10.3233\/JAD-240483_ref80","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1136\/jnnp.47.2.201","article-title":"A comparison of changes in the nucleus basalis and locus coeruleus in Alzheimer\u2019s disease","volume":"47","author":"Mann","year":"1984","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JAD-240483_ref81","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1126\/science.175.4029.1471","article-title":"Cortical afferents to the entorhinal cortex of the Rhesus monkey","volume":"175","author":"Van Hoesen","year":"1972","journal-title":"Science"},{"key":"10.3233\/JAD-240483_ref82","doi-asserted-by":"crossref","first-page":"1168","DOI":"10.1126\/science.6474172","article-title":"Alzheimer\u2019s disease: cell-specific pathology isolates the hippocampal formation","volume":"225","author":"Hyman","year":"1984","journal-title":"Science"},{"key":"10.3233\/JAD-240483_ref83","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/ana.410200406","article-title":"Perforant pathway changes and the memory impairment of Alzheimer\u2019s disease","volume":"20","author":"Hyman","year":"1986","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-240483_ref84","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1023\/A:1023832305702","article-title":"Alzheimer\u2019s disease as a disconnection syndrome?","volume":"13","author":"Delbeuck","year":"2003","journal-title":"Neuropsychol Rev"},{"key":"10.3233\/JAD-240483_ref85","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.3233\/JAD-230452","article-title":"Microstructural neurodegeneration of the entorhinal-hippocampus pathway along the Alzheimer\u2019s disease continuum","volume":"95","author":"Uchida","year":"2023","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-240483_ref86","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1159\/000365548","article-title":"Patterns of hippocampal tau pathology differentiate neurodegenerative dementias","volume":"38","author":"Milenkovic","year":"2014","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.3233\/JAD-240483_ref87","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.neurobiolaging.2003.09.009","article-title":"Spatial and temporal relationships between plaques and tangles in Alzheimer-pathology","volume":"25","author":"Sch\u00f6nheit","year":"2004","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-240483_ref88","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.3233\/JAD-215567","article-title":"Entorhinal subfield vulnerability to neurofibrillary tangles in aging and the preclinical stage of Alzheimer\u2019s disease","volume":"87","author":"Llamas-Rodr\u00edguez","year":"2022","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-240483_ref89","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s00401-012-1044-y","article-title":"Neuropathologically defined subtypes of Alzheimer\u2019s disease differ significantly from neurofibrillary tangle-predominant dementia","volume":"124","author":"Janocko","year":"2012","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref90","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/BF00296494","article-title":"Neurofibrillary tangle predominant form of senile dementia of Alzheimer type: a rare subtype in very old subjects","volume":"88","author":"Bancher","year":"1994","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref91","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1750-3639.1998.tb00160.x","article-title":"Senile dementia with tangles (tangle predominant form of senile dementia)","volume":"8","author":"Jellinger","year":"1998","journal-title":"Brain Pathol"},{"key":"10.3233\/JAD-240483_ref92","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00401-006-0156-7","article-title":"Neurofibrillary tangle-predominant dementia: comparison with classical Alzheimer disease","volume":"113","author":"Jellinger","year":"2007","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref93","first-page":"257","article-title":"Abundant neurofibrillary tangles without senile plaques in a subset of patients with senile dementia","volume":"1","author":"Ulrich","year":"1992","journal-title":"Neurodegeneration"},{"key":"10.3233\/JAD-240483_ref94","doi-asserted-by":"crossref","first-page":"4065","DOI":"10.3390\/ijms25074065","article-title":"Ageing-related neurodegeneration and cognitive decline","volume":"25","author":"Alafuzoff","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.3233\/JAD-240483_ref95","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s004010050726","article-title":"Low prevalence of apolipoprotein E epsilon 4 allele in the neurofibrillary tangle predominant form of senile dementia","volume":"94","author":"Bancher","year":"1997","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref96","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1002\/ana.410410522","article-title":"A subset of senile dementia with high incidence of the apolipoprotein E epsilon2 allele","volume":"41","author":"Ikeda","year":"1997","journal-title":"Ann Neurol"},{"key":"10.3233\/JAD-240483_ref97","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00401-012-1017-1","article-title":"The MAPT H1 haplotype is associated with tangle-predominant dementia","volume":"124","author":"Santa-Maria","year":"2012","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref98","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41586-023-06437-2","article-title":"Molecular pathology of neurodegenerative diseases by cryo-EM of amyloids","volume":"621","author":"Scheres","year":"2023","journal-title":"Nature"},{"key":"10.3233\/JAD-240483_ref99","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1093\/jnen\/61.12.1040","article-title":"Selective neurofibrillary degeneration of the hippocampal CA2 sector is associated with four-repeat tauopathies","volume":"61","author":"Ishizawa","year":"2002","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-240483_ref100","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s13195-014-0082-1","article-title":"Prevalence of mixed pathologies in the aging brain","volume":"6","author":"Rahimi","year":"2014","journal-title":"Alzheimers Res Ther"},{"key":"10.3233\/JAD-240483_ref101","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jalz.2018.07.215","article-title":"Neuropathologic, genetic, and longitudinal cognitive profiles in primary age-related tauopathy (PART) and Alzheimer\u2019s disease","volume":"15","author":"Bell","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-240483_ref102","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1093\/jnen\/nlac115","article-title":"Cognitive resistance to and resilience against multiple comorbid neurodegenerative pathologies and the impact of APOE status","volume":"82","author":"Walker","year":"2023","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-240483_ref103","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1750-3639.2002.tb00421.x","article-title":"Argyrophilic grain disease: neuropathology, frequency in a dementia brain bank and lack of relationship with apolipoprotein E","volume":"12","author":"Togo","year":"2002","journal-title":"Brain Pathol"},{"key":"10.3233\/JAD-240483_ref104","doi-asserted-by":"crossref","first-page":"46","DOI":"10.5414\/NPP28046","article-title":"Hippocampal pathology in progressive supranuclear palsy (PSP): a quantitative study of 8 cases","volume":"28","author":"Armstrong","year":"2009","journal-title":"Clin Neuropathol"},{"key":"10.3233\/JAD-240483_ref105","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10072-012-1006-0","article-title":"Spatial patterns of the tau pathology in progressive supranuclear palsy","volume":"34","author":"Armstrong","year":"2013","journal-title":"Neurol Sci"},{"key":"10.3233\/JAD-240483_ref106","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1093\/brain\/awm104","article-title":"Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson\u2019s syndrome","volume":"130","author":"Williams","year":"2007","journal-title":"Brain"},{"key":"10.3233\/JAD-240483_ref107","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1093\/jnen\/63.9.911","article-title":"Staging of argyrophilic grains: an age-associated tauopathy","volume":"63","author":"Saito","year":"2004","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-240483_ref108","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1093\/brain\/awm305","article-title":"Argyrophilic grain disease","volume":"131","author":"Ferrer","year":"2008","journal-title":"Brain"},{"key":"10.3233\/JAD-240483_ref109","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1365-2990.1989.tb01146.x","article-title":"Cortical and subcortical argyrophilic grains characterize a disease associated with adult onset dementia","volume":"15","author":"Braak","year":"1989","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.3233\/JAD-240483_ref110","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1007\/s007020050096","article-title":"Argyrophilic grain disease: frequency of occurrence in different age categories and neuropathological diagnostic criteria","volume":"105","author":"Braak","year":"1998","journal-title":"J Neural Transm"},{"key":"10.3233\/JAD-240483_ref111","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s004010050718","article-title":"Argyrophilic grain disease: distribution of grains in patients with and without dementia","volume":"94","author":"Tolnay","year":"1997","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref112","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1111\/j.1440-1789.2004.00591.x","article-title":"Argyrophilic grain disease: a late-onset dementia with distinctive features among tauopathies","volume":"24","author":"Tolnay","year":"2004","journal-title":"Neuropathology"},{"key":"10.3233\/JAD-240483_ref113","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/brain\/aww230","article-title":"Like prions: the propagation of aggregated tau and \u03b1-synuclein in neurodegeneration","volume":"140","author":"Goedert","year":"2017","journal-title":"Brain"},{"key":"10.3233\/JAD-240483_ref114","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.3233\/JAD-170727","article-title":"Modeling prion-like processing of tau protein in Alzheimer\u2019s disease for pharmaceutical development","volume":"62","author":"Wischik","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-240483_ref115","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1007\/s00401-021-02294-3","article-title":"Cryo-EM structures of tau filaments from Alzheimer\u2019s disease with PET ligand APN-1607","volume":"141","author":"Shi","year":"2021","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref116","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41586-021-03911-7","article-title":"Structure-based classification of tauopathies","volume":"598","author":"Shi","year":"2021","journal-title":"Nature"},{"key":"10.3233\/JAD-240483_ref117","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s00401-018-1855-6","article-title":"Tau seeding activity begins in the transentorhinal\/entorhinal regions and anticipates phospho-tau pathology in Alzheimer\u2019s disease and PART","volume":"136","author":"Kaufman","year":"2018","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref118","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/BF00293315","article-title":"A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads","volume":"87","author":"Braak","year":"1994","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref119","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.bbadis.2004.08.014","article-title":"Tau, tangles, and Alzheimer\u2019s disease","volume":"1739","author":"Binder","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.3233\/JAD-240483_ref120","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/acn3.581","article-title":"Alzheimer\u2019s genetic risk is reduced in primary age-related tauopathy: a potential model of resistance?","volume":"5","author":"McMillan","year":"2018","journal-title":"Ann Clin Transl Neurol"},{"key":"10.3233\/JAD-240483_ref121","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/00005072-199311000-00006","article-title":"The lack of accumulation of senile plaques or amyloid burden in Alzheimer\u2019s disease suggests a dynamic balance between amyloid deposition and resolution","volume":"52","author":"Hyman","year":"1993","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-240483_ref122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-12679-1_1","article-title":"Neuroanatomy and pathology of sporadic Alzheimer\u2019s disease","volume":"215","author":"Braak","year":"2015","journal-title":"Adv Anat Embryol Cell Biol"},{"key":"10.3233\/JAD-240483_ref123","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/0006-8993(89)91396-6","article-title":"Accumulation of abnormally phosphorylated tau precedes the formation of neurofibrillary tangles in Alzheimer*s disease","volume":"477","author":"Bancher","year":"1989","journal-title":"Brain Res"},{"key":"10.3233\/JAD-240483_ref124","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0006-8993(91)90681-K","article-title":"Abnormal phosphorylation of tau precedes ubiquitination in neurofibrillary pathology of Alzheimer disease","volume":"539","author":"Bancher","year":"1991","journal-title":"Brain Res"},{"key":"10.3233\/JAD-240483_ref125","first-page":"1167","article-title":"Tangle-associated neuritic clusters: a new lesion in Alzheimer`s disease and aging suggests that aggregates of dystrophic neurites are not necessarily associated with \u03b2\/A4","volume":"140","author":"Munoz","year":"1992","journal-title":"Am J Pathol"},{"key":"10.3233\/JAD-240483_ref126","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0891-0618(01)00096-5","article-title":"Accumulation of C-terminally truncated tau protein associated with vulnerability of the perforant pathway in early stages of neurofibrillary pathology in Alzheimer\u2019s disease","volume":"22","author":"Garc\u00eda-Sierra","year":"2001","journal-title":"J Chem Neuroanat"},{"key":"10.3233\/JAD-240483_ref127","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1007\/s004010100423","article-title":"Specific tau phosphorylation sites correlate with severity of neuronal cytopathology in Alzheimer\u2019s disease","volume":"103","author":"Augustinack","year":"2002","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref128","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s00401-014-1356-1","article-title":"Are cases with tau pathology occurring in the absence of A\u03b2 deposits part of the AD-related pathological process?","volume":"128","author":"Braak","year":"2014","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref129","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1002\/alz.12321","article-title":"Visualization of neurofibrillary tangle maturity in Alzheimer\u2019s disease: A clinicopathologic perspective for biomarker research","volume":"17","author":"Moloney","year":"2021","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-240483_ref130","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1097\/NEN.0b013e3181aacbe9","article-title":"Brains with medial temporal lobe neurofibrillary tangles but no neuritic amyloid plaques are a diagnostic dilemma but may have pathogenetic aspects distinct from Alzheimer disease","volume":"68","author":"Nelson","year":"2009","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-240483_ref131","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1212\/WNL.0000000000004521","article-title":"Comparison of symptomatic and asymptomatic persons with primary age-related tauopathy","volume":"89","author":"Besser","year":"2017","journal-title":"Neurology"},{"key":"10.3233\/JAD-240483_ref132","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/jnen\/nlw002","article-title":"Altered proteins in the aging brain","volume":"75","author":"Elobeid","year":"2016","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.3233\/JAD-240483_ref133","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s13311-021-01146-y","article-title":"Neuropathology of Alzheimer\u2019s disease","volume":"19","author":"Trejo-Lopez","year":"2022","journal-title":"Neurotherapeutics"},{"key":"10.3233\/JAD-240483_ref134","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.neurobiolaging.2003.12.015","article-title":"Alzheimer\u2019s disease: intraneuronal alterations precede insoluble amyloid-\u03b2 formation","volume":"25","author":"Braak","year":"2004","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-240483_ref135","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00401-009-0532-1","article-title":"Classification and basic pathology of Alzheimer disease","volume":"118","author":"Duyckaerts","year":"2009","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref136","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s40478-015-0187-1","article-title":"Early neurone loss in Alzheimer\u2019s disease: cortical or subcortical?","volume":"3","author":"Arendt","year":"2015","journal-title":"Acta Neuropathol Commun"},{"key":"10.3233\/JAD-240483_ref137","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.brainresbull.2016.08.018","article-title":"Tau and tauopathies","volume":"126","author":"Arendt","year":"2016","journal-title":"Brain Res Bull"},{"key":"10.3233\/JAD-240483_ref138","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/bpa.12289","article-title":"Precortical phase of Alzheimer\u2019s disease (AD)-related tau cytoskeletal pathology","volume":"26","author":"Stratmann","year":"2016","journal-title":"Brain Pathol"},{"key":"10.3233\/JAD-240483_ref139","first-page":"42","article-title":"Locus coeruleus at asymptomatic early and middle Braak stages of neurofibrillary tangle pathology","volume":"38","author":"Andr\u00e9s-Benito","year":"2017","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.3233\/JAD-240483_ref140","first-page":"42","article-title":"Quantifying the accretion of hyperphosphorylated tau in the locus coeruleus and dorsal raphe nucleus","volume":"38","author":"Ehrenberg","year":"2017","journal-title":"Neuropathol Appl Neurobiol"},{"key":"10.3233\/JAD-240483_ref141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40478-017-0501-1","article-title":"Brainstem tau pathology in Alzheimer\u2019s disease is characterized by increase of three repeat tau and independent of amyloid \u03b2","volume":"6","author":"Uematsu","year":"2018","journal-title":"Acta Neuropathol Commun"},{"key":"10.3233\/JAD-240483_ref142","doi-asserted-by":"crossref","first-page":"eabj2511","DOI":"10.1126\/scitranslmed.abj2511","article-title":"In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer\u2019s disease pathology and cognitive decline","volume":"13","author":"Jacobs","year":"2021","journal-title":"Sci Transl Med"},{"issue":"Suppl 1","key":"10.3233\/JAD-240483_ref143","first-page":"S1","article-title":"Consensus recommendations for the postmortem diagnosis of Alzheimer\u2019s disease","volume":"18","author":"Ball","year":"1997","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-240483_ref144","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0197-4580(97)00047-X","article-title":"Prevalence, incidence and duration of Braak\u2019s stages in the general population: Can we know?","volume":"18","author":"Duyckaerts","year":"1997","journal-title":"Neurobiol Aging"},{"key":"10.3233\/JAD-240483_ref145","doi-asserted-by":"crossref","first-page":"eabc0655","DOI":"10.1126\/scitranslmed.abc0655","article-title":"The cortical origin and initial spread of medial temporal tauopathy in Alzheimer\u2019s disease assessed with positron emission tomography","volume":"13","author":"Sanchez","year":"2021","journal-title":"Sci Transl Med"},{"issue":"1","key":"10.3233\/JAD-240483_ref146","doi-asserted-by":"crossref","first-page":"e13122","DOI":"10.1111\/bpa.13122","article-title":"Hypothesis review: Alzheimer\u2019s overture guidelines","volume":"33","author":"Ferrer","year":"2023","journal-title":"Brain Pathol"},{"key":"10.3233\/JAD-240483_ref147","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00401-017-1740-8","article-title":"[F-18]-AV-1451 binding correlates with postmortem neurofibrillary tangle Braak staging","volume":"134","author":"Marqui\u00e9","year":"2017","journal-title":"Acta Neuropathol"},{"key":"10.3233\/JAD-240483_ref148","doi-asserted-by":"crossref","first-page":"106279","DOI":"10.1016\/j.eplepsyres.2020.106279","article-title":"Hippocampal subfield measurement and ILAE hippocampal sclerosis subtype classification with in vivo 4.7 tesla MRI","volume":"161","author":"Steve","year":"2020","journal-title":"Epilepsy Res"},{"key":"10.3233\/JAD-240483_ref149","doi-asserted-by":"crossref","first-page":"1114757","DOI":"10.3389\/fnana.2023.1114757","article-title":"Pentad: A reproducible cytoarchitectonic protocol and its application to parcellation of the human hippocampus","volume":"17","author":"Williams","year":"2023","journal-title":"Front Neuroanat"},{"key":"10.3233\/JAD-240483_ref150","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s00429-023-02725-9","article-title":"Immunohistochemical field parcellation of the human hippocampus along its antero-posterior axis","volume":"229","author":"Gonz\u00e1lez-Arnay","year":"2024","journal-title":"Brain Struct Funct"}],"container-title":["Journal of Alzheimer's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JAD-240483","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:59:10Z","timestamp":1777370350000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.medra.org\/servlet\/aliasResolver?alias=iospress&doi=10.3233\/JAD-240483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,8]]},"references-count":150,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3233\/jad-240483","relation":{},"ISSN":["1387-2877","1875-8908"],"issn-type":[{"value":"1387-2877","type":"print"},{"value":"1875-8908","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,8]]}}}