{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:05:16Z","timestamp":1782317116099,"version":"3.54.5"},"reference-count":54,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Alzheimer\u2019s Disease"],"published-print":{"date-parts":[[2024,9,24]]},"abstract":"<jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Cognitive impairment is a clinical manifestation that occurs in the course of dementia like Alzheimer\u2019s disease. The association between cognitive impairment and gut microbiota is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>We aimed to identify gut microbiota characteristics and key gut microbiota biomarkers associated with cognitive impairment in a relatively large cohort of older adults in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>A total of 229 adults aged \u226560 years from Shenzhen, China were recruited into this cross-sectional study. Participants were divided into cognitive impairment (CI) and no cognitive impairment (NCI) groups according to the results of the Mini-Mental State Examination. Diversity analysis and network analysis were used to characterize the gut microbiota between the two groups. The linear discriminant analysis effect size method and machine learning approaches were sequentially performed to identify gut microbiota biomarkers. The relationship between biomarkers and lifestyle factors was explored using Transformation-based redundancy analysis (tb-RDA).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      A total of 74 CI participants and 131 NCI participants were included in the analysis. The CI group demonstrated lower\n                      <jats:italic>\u03b1<\/jats:italic>\n                      -diversity compared to the NCI group (Shannon: 2.798 versus 3.152,\n                      <jats:italic>p<\/jats:italic>\n                      \u200a&lt;\u200a0.001). The density of the gut microbiota interaction network was lower in the CI group (0.074) compared to the NCI group (0.081). Megamonas, Blautia, Pseudomonas, Stenotrophomonas, and Veillonella were key biomarkers for CI. The tb-RDA revealed that increased fruit intake and exercise contribute to a higher abundance of Megamonas, Blautia, and Veillonella.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec specific-use=\"heading-level-1\">\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>We identified a significantly reduced abundance of certain beneficial gut microbiota in older Chinese adults with cognitive impairment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jad-240597","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T11:14:36Z","timestamp":1725016476000},"page":"761-771","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Characterizing Gut Microbiota in Older Chinese Adults with Cognitive Impairment: A Cross-Sectional Study"],"prefix":"10.1177","volume":"101","author":[{"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"China-Australia Joint Research Centre for Infectious Diseases, School of Public Health, Xi\u2019an Jiaotong University Health Science Centre, Xi\u2019an, Shaanxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gong","family":"Zhang","sequence":"additional","affiliation":[{"name":"MOE Key Laboratory of Tumour Molecular Biology and Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes, Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Lai","sequence":"additional","affiliation":[{"name":"China-Australia Joint Research Centre for Infectious Diseases, School of Public Health, Xi\u2019an Jiaotong University Health Science Centre, Xi\u2019an, Shaanxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengbin","family":"Li","sequence":"additional","affiliation":[{"name":"China-Australia Joint Research Centre for Infectious Diseases, School of Public Health, Xi\u2019an Jiaotong University Health Science Centre, Xi\u2019an, Shaanxi, PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwang","family":"Shen","sequence":"additional","affiliation":[{"name":"China-Australia Joint Research Centre for Infectious Diseases, School of Public Health, Xi\u2019an Jiaotong University Health Science Centre, Xi\u2019an, Shaanxi, PR China"},{"name":"Key Laboratory for Disease Prevention and Control and Health Promotion of Shaanxi Province, Xi\u2019an, Shaanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, School of Public Health, Xi\u2019an Jiaotong University Health Science Centre, Xi\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Kwan","sequence":"additional","affiliation":[{"name":"The Department of Neuroscience, The School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University &amp; Alfred Health, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence J.","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"The Department of Neuroscience, The School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University &amp; Alfred Health, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"},{"name":"Medical Research Institute, Guangdong Provincial People\u2019s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[{"name":"China-Australia Joint Research Centre for Infectious Diseases, School of Public Health, Xi\u2019an Jiaotong University Health Science Centre, Xi\u2019an, Shaanxi, PR China"},{"name":"The Department of Neuroscience, The School of Translational Medicine, Faculty of Medicine, Nursing and Health Sciences, Monash University &amp; Alfred Health, Melbourne, Australia"},{"name":"Artificial Intelligence and Modelling in Epidemiology Program, Melbourne Sexual Health Centre, Alfred Health, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,8,30]]},"reference":[{"key":"e_1_3_6_2_2","unstructured":"Health direct. 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