{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:56:11Z","timestamp":1790052971321,"version":"4.0.1"},"reference-count":25,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T00:00:00Z","timestamp":1728345600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,10,8]]},"abstract":"<jats:p>Hippocampal dysfunction is associated with early clinical signs of Alzheimer\u2019s disease (AD). Due to the limited availability or invasiveness of current biomarkers, the AD diagnosis is usually based on cognitive assessment and structural brain imaging. The recent study by Lalive and colleagues examined the specificity of brain morphometry for the AD diagnosis in a memory clinic cohort with hippocampal-type amnestic syndrome. The results indicate that memory deficits and hippocampal atrophy are similar in AD and non-AD patients, highlighting their low diagnostic specificity. These findings challenge the traditional AD diagnosis and underscore the need for biomarkers to differentiate specific neuropathological entities.<\/jats:p>","DOI":"10.3233\/jad-240660","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T11:38:40Z","timestamp":1726227520000},"page":"1133-1136","source":"Crossref","is-referenced-by-count":7,"title":["Diagnosis of Alzheimer\u2019s Disease in Clinical Practice: Time to Incorporate Biomarkers?"],"prefix":"10.1177","volume":"101","author":[{"given":"Martin","family":"Vyhnalek","sequence":"first","affiliation":[{"name":"Memory Clinic, Department of Neurology, Second Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czechia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Lacz\u00f3","sequence":"additional","affiliation":[{"name":"Memory Clinic, Department of Neurology, Second Faculty of Medicine, Charles University and Motol University 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