{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:22:28Z","timestamp":1782300148025,"version":"3.54.5"},"reference-count":52,"publisher":"SAGE Publications","issue":"s1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JAD"],"published-print":{"date-parts":[[2024,8,20]]},"abstract":"<jats:p>Background: With advancing age, cognitive decline is frequently associated with endothelial dysfunction, but data on vascular performance prior to the onset of mild cognitive impairment (MCI) is scarce. Objective: To investigate the relationship between endothelial function, vital parameters and cognitive performance in older adults with subjective cognitive decline (SCD). Methods: Forty-five volunteers aged 65 years and older with SCD underwent comprehensive geriatric assessment-based prognosis evaluation by means of the Multidimensional Prognostic Index (MPI), full neuropsychological examination and peripheral arterial tonometry measurement by means of EndoPAT\u21222000 to evaluate endothelial flexibility and vital parameters. Six months after initial evaluation, participants were contacted by phone and a telephone-administered version of the MPI (TELE-MPI) was conducted. Results: Fifteen study participants scored below the cutoff score of 26 on the Montreal Cognitive Assessment, suggesting MCI (26.56\u00b12.23). Nominal significant correlations were found between heart rate (HR) and trail making test (TMT) A (\u03b2=\u200a\u20130.49, p\u200a=\u200a0.03), between heart rate variability (HRV) and TMT B (\u03b2=\u200a0.78, p\u200a=\u200a0.041), between power of low-frequency band (LF) HRV and Mini Nutritional Assessment-Short Form (\u03b2=\u200a0.007, p\u200a=\u200a0.037) as well as between augmentation index (AI) and CogState Detection Test (\u03b2=\u200a0.002, p\u200a=\u200a0.034). Conclusions: HR, HRV, and AI, but not endothelial flexibility are associated with cognitive performance in SCD and suspected MCI patients and may serve as clinical biomarkers in the early diagnosis of neurodegenerative disorders with advancing age.<\/jats:p>","DOI":"10.3233\/jad-240661","type":"journal-article","created":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T11:50:56Z","timestamp":1723809056000},"page":"S13-S24","source":"Crossref","is-referenced-by-count":1,"title":["Relationship Between Endothelial Function, Vital Parameters, and Cognitive Performance in Community Dwellers with Subjective Cognitive Decline: An Observational Study with Six Months Follow Up"],"prefix":"10.1177","volume":"100","author":[{"given":"Johannes","family":"Sittig","sequence":"first","affiliation":[{"name":"Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lena","family":"Pickert","sequence":"additional","affiliation":[{"name":"Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Weigert","sequence":"additional","affiliation":[{"name":"Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joris","family":"Deelen","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Biology of Ageing, Cologne, Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Cristina","family":"Polidori","sequence":"additional","affiliation":[{"name":"Ageing Clinical Research, Department II of Internal Medicine and Center for Molecular Medicine Cologne, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany"},{"name":"Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gereon","family":"Nelles","sequence":"additional","affiliation":[{"name":"Neuromed-Campus Hohenlind, Cologne, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JAD-240661_ref1","doi-asserted-by":"crossref","first-page":"521","DOI":"10.3233\/JAD-2012-120871","article-title":"A review of the major vascular risk factors related to Alzheimer\u2019s disease","volume":"32","author":"Polidori","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"10.3233\/JAD-240661_ref2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0140-6736(20)30367-6","article-title":"Dementia prevention, intervention, and care: 2020 report of the Lancet Commission","volume":"396","author":"Livingston","year":"2020","journal-title":"Lancet"},{"key":"10.3233\/JAD-240661_ref3","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.jamda.2017.09.020","article-title":"The effect of a 2-year intervention consisting of diet, physical exercise, cognitive training, and monitoring of vascular risk on chronic morbidity-the FINGER randomized controlled trial","volume":"19","author":"Marengoni","year":"2018","journal-title":"J Am Med Dir Assoc"},{"key":"10.3233\/JAD-240661_ref4","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1212\/WNL.84.14_supplement.P7.114","article-title":"Endothelium-mediated changes in vascular tone and cognitive function in patients with subjective cognitive impairment: a pilot study (P7.114)","author":"Nelles","year":"2015","journal-title":"Neurology"},{"key":"10.3233\/JAD-240661_ref5","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.3390\/ijms18091965","article-title":"Blood-brain barrier dysfunction and the pathogenesis of Alzheimer\u2019s disease","volume":"18","author":"Yamazaki","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.3233\/JAD-240661_ref6","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/bpa.12405","article-title":"Cerebral perfusion enhancing interventions: a new strategy for the prevention of Alzheimer dementia","volume":"26","author":"De la Torre","year":"2016","journal-title":"Brain Pathol"},{"key":"10.3233\/JAD-240661_ref7","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.jalz.2014.01.001","article-title":"A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer\u2019s disease","volume":"10","author":"Jessen","year":"2014","journal-title":"Alzheimers Dement"},{"key":"10.3233\/JAD-240661_ref8","doi-asserted-by":"crossref","first-page":"102012","DOI":"10.1016\/j.arr.2023.102012","article-title":"Efficacy and safety of anti-amyloid-\u03b2 monoclonal antibodies in current Alzheimer\u2019s disease phase III clinical trials: A systematic review and interactive web app-based meta-analysis","volume":"90","author":"Jeremic","year":"2023","journal-title":"Ageing Res Rev"},{"key":"10.3233\/JAD-240661_ref9","unstructured":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019. 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