{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:57:11Z","timestamp":1777687031163,"version":"3.51.4"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Huntington's Disease"],"published-print":{"date-parts":[[2014,2]]},"abstract":"<jats:p>Background: Increasingly, evidence from studies in both animal models and patients suggests that cardiovascular dysfunction is important in HD. Previous studies measuring function of the left ventricle (LV) in the R6\/2 mouse model have found a clear cardiac abnormality, albeit with preserved LV systolic function. It was hypothesized that an impairment of RV function might play a role in this condition via mechanisms of ventricular interdependence. Objective: To investigate RV function in the R6\/2 mouse model of Huntington's disease (HD). Methods: Cardiac cine-magnetic resonance imaging (MRI) was used to determine functional parameters in R6\/2 mice. In a first experiment, these parameters were derived longitudinally to determine deterioration of cardiac function with disease progression. A second experiment compared the response to a stress test (using dobutamine) of wildtype and early-symptomatic R6\/2 mice. Results: There was progressive deterioration of RV systolic function with age in R6\/2 mice. Furthermore, beta-adrenergic stimulation with dobutamine revealed RV dysfunction in R6\/2 mice before any overt symptoms of the disease were apparent. Conclusions: This work adds to accumulating evidence of cardiovascular dysfunction in R6\/2 mice, describing for the first time the involvement of the right ventricle. Cardiovascular dysfunction should be considered, both when treatment strategies are being designed, and when searching for biomarkers for HD.<\/jats:p>","DOI":"10.3233\/jhd-130083","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T09:12:49Z","timestamp":1575364369000},"page":"25-32","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":17,"title":["Right Ventricular Dysfunction in the R6\/2 Transgenic Mouse Model of Huntington's Disease is Unmasked by Dobutamine"],"prefix":"10.1177","volume":"3","author":[{"given":"Guido","family":"Buonincontri","sequence":"first","affiliation":[{"name":"Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nigel I.","family":"Wood","sequence":"additional","affiliation":[{"name":"Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Site, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon G.","family":"Puttick","sequence":"additional","affiliation":[{"name":"Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Site, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex O.","family":"Ward","sequence":"additional","affiliation":[{"name":"Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. Adrian","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Sawiak","sequence":"additional","affiliation":[{"name":"Wolfson Brain Imaging Centre, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK"},{"name":"Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Jennifer","family":"Morton","sequence":"additional","affiliation":[{"name":"Department of Physiology, Development and Neuroscience, University of Cambridge, Downing Site, Cambridge, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2014,1,1]]},"container-title":["Journal of Huntington's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JHD-130083","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JHD-130083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:56:50Z","timestamp":1777453010000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JHD-130083"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["10.3233\/JHD-130083"],"URL":"https:\/\/doi.org\/10.3233\/jhd-130083","relation":{},"ISSN":["1879-6397","1879-6400"],"issn-type":[{"value":"1879-6397","type":"print"},{"value":"1879-6400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,1]]}}}