{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:58:11Z","timestamp":1777687091734,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHD"],"published-print":{"date-parts":[[2015,7,1]]},"DOI":"10.3233\/jhd-150147","type":"journal-article","created":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T11:54:18Z","timestamp":1435751658000},"page":"149-160","source":"Crossref","is-referenced-by-count":11,"title":["In Vivo MRI Evidence that Neuropathology is Attenuated by Cognitive Enrichment in the Yac128 Huntington\u2019s Disease Mouse Model"],"prefix":"10.1177","volume":"4","author":[{"given":"Jessica J.","family":"Steventon","sequence":"first","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Park Place, Cardiff, UK"},{"name":"Brain Repair Group, Life Science Building, 3rd Floor, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK"},{"name":"Experimental MRI Centre (EMRIC), School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J.","family":"Harrison","sequence":"additional","affiliation":[{"name":"Brain Repair Group, Life Science Building, 3rd Floor, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca C.","family":"Trueman","sequence":"additional","affiliation":[{"name":"Brain Repair Group, Life Science Building, 3rd Floor, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK"},{"name":"School of Biomedical Sciences, Queen\u2019s Medical Centre, Nottingham University, Nottingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne E.","family":"Rosser","sequence":"additional","affiliation":[{"name":"Brain Repair Group, Life Science Building, 3rd Floor, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek K.","family":"Jones","sequence":"additional","affiliation":[{"name":"Cardiff University Brain Research Imaging Centre, School of Psychology, Cardiff University, Park Place, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon P.","family":"Brooks","sequence":"additional","affiliation":[{"name":"Brain Repair Group, Life Science Building, 3rd Floor, School of Biosciences, Cardiff University, Museum Avenue, Cardiff, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"7","key":"10.3233\/JHD-150147_ref1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1177\/0269215507075495","article-title":"Effects of an intensive rehabilitation programme on patients with Huntington\u2019s disease: A pilot study","volume":"21","author":"Zinzi","year":"2007","journal-title":"Clin Rehabil"},{"key":"10.3233\/JHD-150147_ref2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrn1970","article-title":"Enriched environments, experience-dependent plasticity and disorders of the nervous system","volume":"7","author":"Nithianantharajah","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"10.3233\/JHD-150147_ref3","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1097\/00001756-200011270-00032","article-title":"N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntington\u2019s disease mice","volume":"11","author":"Van Dellen","year":"2000","journal-title":"Neuroreport"},{"key":"10.3233\/JHD-150147_ref4","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2202-9-34","article-title":"Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington\u2019s disease","volume":"9","author":"Van Dellen","year":"2008","journal-title":"BMC Neurosci"},{"key":"10.3233\/JHD-150147_ref5","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1523\/JNEUROSCI.1658-03.2004","article-title":"Environmental enrichment rescues protein deficits in a mouse model of Huntington\u2019s disease, indicating a possible disease mechanism","volume":"24","author":"Spires","year":"2004","journal-title":"J Neurosci"},{"issue":"3","key":"10.3233\/JHD-150147_ref6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.nbd.2011.02.005","article-title":"\u201cBrain training\u201d improves cognitive performance and survival in a transgenic mouse model of Huntington\u2019s disease","volume":"42","author":"Wood","year":"2011","journal-title":"Neurobiol Dis"},{"key":"10.3233\/JHD-150147_ref7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/ana.10094","article-title":"Environmental enrichment slows disease progression in R6\/2 Huntington\u2019s disease mice","volume":"51","author":"Hockly","year":"2002","journal-title":"Ann Neurol"},{"issue":"6779","key":"10.3233\/JHD-150147_ref8","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/35008142","article-title":"Delaying the onset of Huntington\u2019s in mice","volume":"404","author":"Van Dellen","year":"2000","journal-title":"Nature"},{"issue":"5","key":"10.3233\/JHD-150147_ref9","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1073\/pnas.0536856100","article-title":"Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice","volume":"100","author":"Duan","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"10.3233\/JHD-150147_ref10","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.neuroimage.2012.04.010","article-title":"In vivo voxel based morphometry: Detection of increased hippocampal volume and decreased glutamate levels in exercising mice","volume":"61","author":"Biedermann","year":"2012","journal-title":"Neuroimage"},{"issue":"1","key":"10.3233\/JHD-150147_ref11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.nbd.2011.03.018","article-title":"Natural history of disease in the YAC128 mouse reveals a discrete signature of pathology in Huntington disease","volume":"43","author":"Carroll","year":"2011","journal-title":"Neurobiol Dis"},{"key":"10.3233\/JHD-150147_ref12","doi-asserted-by":"crossref","first-page":"e50717","DOI":"10.1371\/journal.pone.0050717","article-title":"Characterization of neurophysiological and behavioral changes, MRI brain volumetry and 1H MRS in zQ175 knock-in mouse model of Huntington\u2019s disease","volume":"7","author":"Heikkinen","year":"2012","journal-title":"PLoS One"},{"key":"10.3233\/JHD-150147_ref13","doi-asserted-by":"crossref","first-page":"e60012","DOI":"10.1371\/journal.pone.0060012","article-title":"Correlations of behavioral deficits with brain pathology assessed through longitudinal MRI and histopathology in the R6\/2 mouse model of HD","volume":"8","author":"Rattray","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"10.3233\/JHD-150147_ref14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.nbd.2008.09.016","article-title":"Voxel-based morphometry in the R6\/2 transgenic mouse reveals differences between genotypes not seen with manual 2D morphometry","volume":"33","author":"Sawiak","year":"2009","journal-title":"Neurobiol Dis"},{"key":"10.3233\/JHD-150147_ref15","doi-asserted-by":"crossref","first-page":"6456","DOI":"10.1523\/JNEUROSCI.0388-12.2012","article-title":"R6\/2 Huntington\u2019s disease mice develop early and progressive abnormal brain metabolism and seizures","volume":"32","author":"Cepeda-Prado","year":"2012","journal-title":"J Neurosci"},{"issue":"4","key":"10.3233\/JHD-150147_ref16","doi-asserted-by":"crossref","first-page":"2086","DOI":"10.1016\/j.neuroimage.2012.01.141","article-title":"Spatiotemporal mapping of brain atrophy in mouse models of Huntington\u2019s disease using longitudinal in vivo magnetic resonance imaging","volume":"60","author":"Aggarwal","year":"2012","journal-title":"Neuroimage"},{"key":"10.3233\/JHD-150147_ref17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0896-6273(00)80764-3","article-title":"A YAC mouse model for Huntington\u2019s disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration","volume":"23","author":"Hodgson","year":"1999","journal-title":"Neuron"},{"issue":"13","key":"10.3233\/JHD-150147_ref18","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1093\/hmg\/ddg169","article-title":"Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease","volume":"12","author":"Slow","year":"2003","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.3233\/JHD-150147_ref19","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jneumeth.2007.03.008","article-title":"An operant serial implicit learning task (SILT) in rats: Task acquisition, performance and the effects of striatal lesions","volume":"163","author":"Jay","year":"2007","journal-title":"J Neurosci Methods"},{"issue":"2","key":"10.3233\/JHD-150147_ref20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bbr.2004.11.021","article-title":"Implicit learning in a serial choice visual discrimination task in the operant 9-hole box by intact and striatal lesioned mice","volume":"159","author":"Trueman","year":"2005","journal-title":"Behav Brain Res"},{"issue":"2","key":"10.3233\/JHD-150147_ref21","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/j.1460-9568.2007.05307.x","article-title":"The operant serial implicit learning task reveals early onset motor learning deficits in the Hdh knock-in mouse model of Huntington\u2019s disease","volume":"25","author":"Trueman","year":"2007","journal-title":"Eur J Neurosci"},{"issue":"1","key":"10.3233\/JHD-150147_ref22","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1006\/nimg.2002.1040","article-title":"Accurate, robust, and automated longitudinal and cross-sectional brain change analysis","volume":"17","author":"Smith","year":"2002","journal-title":"Neuroimage"},{"issue":"4","key":"10.3233\/JHD-150147_ref24","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1111\/j.2042-7158.1968.tb09743.x","article-title":"The quantiative measurement of motor inco-ordination in naive mice using an acelerating rotarod","volume":"20","author":"Jones","year":"1968","journal-title":"J Pharm Pharmacol"},{"issue":"2-3","key":"10.3233\/JHD-150147_ref25","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.brainresbull.2011.05.010","article-title":"Selective cognitive impairment in the YAC128 Huntington\u2019s disease mouse","volume":"88","author":"Brooks","year":"2012","journal-title":"Brain Res Bull"},{"issue":"2-3","key":"10.3233\/JHD-150147_ref26","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.brainresbull.2010.05.005","article-title":"Longitudinal analysis of the behavioural phenotype in YAC128 (C57BL\/6J) Huntington\u2019s disease transgenic mice","volume":"88","author":"Brooks","year":"2012","journal-title":"Brain Res Bull"},{"issue":"1","key":"10.3233\/JHD-150147_ref27","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuroimage.2007.08.033","article-title":"Automated deformation analysis in the YAC128 Huntington disease mouse model","volume":"39","author":"Lerch","year":"2008","journal-title":"Neuroimage"},{"issue":"3-4","key":"10.3233\/JHD-150147_ref28","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainresbull.2010.04.003","article-title":"Striatal and white matter predictors of estimated diagnosisfor Huntington disease","volume":"82","author":"Paulsen","year":"2010","journal-title":"Brain Res Bull"},{"issue":"9","key":"10.3233\/JHD-150147_ref29","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/j.biopsych.2011.07.030","article-title":"Striatal volume contributes to the prediction of onset of Huntington disease in incident cases","volume":"71","author":"Aylward","year":"2012","journal-title":"Biol Psychiatry"},{"issue":"3","key":"10.3233\/JHD-150147_ref30","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.nbd.2010.07.014","article-title":"Cerebral cortex structure in prodromal Huntington disease","volume":"40","author":"Nopoulos","year":"2010","journal-title":"Neurobiol Dis"},{"key":"10.3233\/JHD-150147_ref31","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.expneurol.2013.07.014","article-title":"Exercise attenuates neuropathology and has greater benefit on cognitive than motor deficits in the R6\/1 Huntington\u2019s disease mouse model","volume":"248","author":"Harrison","year":"2013","journal-title":"Exp Neurol"}],"container-title":["Journal of Huntington's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JHD-150147","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:57:01Z","timestamp":1777453021000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JHD-150147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7,1]]},"references-count":30,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jhd-150147","relation":{},"ISSN":["1879-6397","1879-6400"],"issn-type":[{"value":"1879-6397","type":"print"},{"value":"1879-6400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,7,1]]}}}