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We used small-pool PCR to generate a modified instability index to quantify CAG instability within two brain regions from six human samples where cell loss has been associated with motor and mood symptoms: the motor cortex and cingulate gyrus. The expanded allele demonstrated instability in both regions, with minimal instability in the unexpanded allele. Region-specific differences were not observed, suggesting symptomatology may not be determined by repeat length instability.<\/jats:p>","DOI":"10.3233\/jhd-160203","type":"journal-article","created":{"date-parts":[[2016,10,4]],"date-time":"2016-10-04T11:46:07Z","timestamp":1475581567000},"page":"297-301","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Comparison of Huntington\u2019s disease CAG Repeat Length Stability in Human Motor Cortex and Cingulate Gyrus"],"prefix":"10.1177","volume":"5","author":[{"given":"Fiona C.A.","family":"Geraerts","sequence":"first","affiliation":[{"name":"School of Biological Sciences, Centre for Brain Research, Faculty of Science, The University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell G.","family":"Snell","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Centre for Brain Research, Faculty of Science, The University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard L.M.","family":"Faull","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Medical Imaging, Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liam","family":"Williams","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Centre for Brain Research, Faculty of Science, The University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessie C.","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Centre for Brain Research, Faculty of Science, The University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne J.","family":"Reid","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Centre for Brain Research, Faculty of Science, The University of Auckland, Auckland, New Zealand"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,10,1]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029522"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1007\/BF03401575"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24162"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm054"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq047"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800048105"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg352"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp242"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2007.01.002"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.050930"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/8.1.115"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl243"},{"key":"ref014","unstructured":"SambrookJ, FritschE, ManiatisT. 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