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The\n                    <jats:italic>Huntingtin<\/jats:italic>\n                    gene (\n                    <jats:italic>HTT<\/jats:italic>\n                    ) carries a polymorphic trinucleotide expansion of CAGs in exon 1 that ranges from 9 to 35 in the non-HD affected population. However, if it exceeds 35 CAG repeats, the altered protein is referred to as mutant\n                    <jats:italic>HTT<\/jats:italic>\n                    and leads to the development of HD. Given the wide spectrum of severe symptoms developed by HD individuals, wild-type and mutant HTT have been mostly studied in the context of this disorder. However, HTT expression is ubiquitous and several peripheral symptoms in HD have been described, suggesting that HTT is of importance, not only in the central nervous system (CNS), but also in peripheral organs. Accordingly, HTT and mutant HTT may interfere with non-brain-related diseases. Correlative studies have highlighted a decreased cancer incidence in the HD population and both wild-type and mutant HTT have been implicated in tumor progression. In this review, we describe the current evidence linking wild-type and mutant HTT to cancer and discuss how CAG polymorphism, HTT function, and partners may influence carcinogenesis and metastatic progression.\n                  <\/jats:p>","DOI":"10.3233\/jhd-180290","type":"journal-article","created":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T14:34:47Z","timestamp":1528209287000},"page":"201-208","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":23,"title":["Cancer: From Wild-Type to Mutant Huntingtin"],"prefix":"10.1177","volume":"7","author":[{"given":"Morgane Sonia","family":"Thion","sequence":"first","affiliation":[{"name":"Institut de Biologie de l\u2019Ecole Normale Sup\u00e9rieure (IBENS), Ecole Normale Sup\u00e9rieure, CNRS, INSERM, PSL Research University, Paris Cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Humbert","sequence":"additional","affiliation":[{"name":"Grenoble Institut des Neurosciences, GIN, Univ. 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