{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:25:07Z","timestamp":1777685107066,"version":"3.51.4"},"reference-count":85,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHD"],"published-print":{"date-parts":[[2019,4,30]]},"DOI":"10.3233\/jhd-180332","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T12:44:22Z","timestamp":1553863462000},"page":"199-219","source":"Crossref","is-referenced-by-count":1,"title":["Concurrent Cross-Sectional and Longitudinal Analyses of Multivariate White Matter Profiles and Clinical Functioning in Pre-Diagnosis Huntington Disease"],"prefix":"10.1177","volume":"8","author":[{"given":"Jennifer A.","family":"Ciarochi","sequence":"first","affiliation":[{"name":"Neuroscience Institute, Georgia State University, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"the PREDICT-HD Investigators and Coordinators of the Huntington Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, 1402 Seamans Center for the Engineering Arts and Science, The University of Iowa, Iowa City, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vince D.","family":"Calhoun","sequence":"additional","affiliation":[{"name":"The Mind Research Network, Albuquerque, NM, USA"},{"name":"Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyu","family":"Liu","sequence":"additional","affiliation":[{"name":"The Mind Research Network, Albuquerque, NM, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flor A.","family":"Espinoza","sequence":"additional","affiliation":[{"name":"The Mind Research Network, Albuquerque, NM, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry J.","family":"Bockholt","sequence":"additional","affiliation":[{"name":"The Mind Research Network, Albuquerque, NM, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Misiura","sequence":"additional","affiliation":[{"name":"Department of Psychology, Georgia State University, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvind","family":"Caprihan","sequence":"additional","affiliation":[{"name":"The Mind Research Network, Albuquerque, NM, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey","family":"Plis","sequence":"additional","affiliation":[{"name":"The Mind Research Network, Albuquerque, NM, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane S.","family":"Paulsen","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Iowa Mental Health Clinical Research Center, University of Iowa, IA, USA"},{"name":"Departments of Neurology and Psychology, University of Iowa, IA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica A.","family":"Turner","sequence":"additional","affiliation":[{"name":"Neuroscience Institute, Georgia State University, Atlanta, GA, USA"},{"name":"Department of Psychology, Georgia State University, Atlanta, GA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"key":"10.3233\/JHD-180332_ref1","first-page":"78","article-title":"Clinical and biomarker changes in premanifest Huntington disease show trial feasibility: A decade of the PREDICT-HD Study","volume":"6","author":"JS","year":"2014","journal-title":"Front Aging Neurosci"},{"issue":"1","key":"10.3233\/JHD-180332_ref2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/brb3.185","article-title":"Neuroanatomical correlates of cognitive functioning in prodromal Huntington disease","volume":"4","author":"DL","year":"2014","journal-title":"Brain Behav"},{"issue":"5","key":"10.3233\/JHD-180332_ref3","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1007\/s11910-011-0215-x","article-title":"Cognitive impairment in Huntington disease: Diagnosis and treatment","volume":"11","author":"JS","year":"2011","journal-title":"Curr Neurol Neurosci Rep"},{"key":"10.3233\/JHD-180332_ref4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.brainres.2007.03.018","article-title":"Olfactory abnormalities in Huntington\u2019s disease: Decreased plasticity in the primary olfactory cortex of R6\/1 transgenic mice and reduced olfactory discrimination in patients","volume":"1151","author":"SE","year":"2007","journal-title":"Brain Res"},{"issue":"5","key":"10.3233\/JHD-180332_ref5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/scan\/nst029","article-title":"Neural correlates of impaired emotion processing in manifest Huntington\u2019s disease","volume":"9","author":"I","year":"2014","journal-title":"Soc Cogn Affect Neurosci."},{"key":"10.3233\/JHD-180332_ref6","first-page":"103","article-title":"Risk-taking and pathological gambling behavior in Huntington\u2019s disease","volume":"8","author":"C","year":"2014","journal-title":"Front Behav Neurosci"},{"issue":"2","key":"10.3233\/JHD-180332_ref7","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1159\/000443738","article-title":"The prevalence of Huntington\u2019s disease","volume":"46","author":"MD","year":"2016","journal-title":"Neuroepidemiology"},{"issue":"5","key":"10.3233\/JHD-180332_ref8","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1172\/JCI66029","article-title":"Thinking laterally about neurodegenerative proteinopathies","volume":"123","author":"TE","year":"2013","journal-title":"J Clin Invest"},{"key":"10.3233\/JHD-180332_ref9","doi-asserted-by":"crossref","unstructured":"A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington\u2019s disease chromosomes. The Huntington\u2019s Disease Collaborative Research Group. Cell. 1993;72(6):971\u201383.","DOI":"10.1016\/0092-8674(93)90585-E"},{"issue":"2","key":"10.3233\/JHD-180332_ref10","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1602\/neurorx.1.2.255","article-title":"Huntington\u2019s disease genetics","volume":"1","author":"RH","year":"2004","journal-title":"NeuroRx"},{"issue":"12","key":"10.3233\/JHD-180332_ref11","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/mds.26364","article-title":"Group P-HIaCotHS. Multivariate prediction of motor diagnosis in Huntington\u2019s disease: 12 years of PREDICT-HD","volume":"30","author":"JD","year":"2015","journal-title":"Mov Disord"},{"issue":"7","key":"10.3233\/JHD-180332_ref12","first-page":"751","article-title":"Indexing disease progression at study entry with individuals at-risk for Huntington disease","volume":"156B","author":"Y","year":"2011","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"10.3233\/JHD-180332_ref13","first-page":"12","article-title":"Refining the diagnosis of Huntington disease: The PREDICT-HD study","volume":"5","author":"KM","year":"2013","journal-title":"Front Aging Neurosci"},{"key":"10.3233\/JHD-180332_ref14","first-page":"147","article-title":"Patterns of co-occurring gray matter concentration loss across the Huntington disease prodrome","volume":"7","author":"JA","year":"2016","journal-title":"Front Neurol"},{"issue":"12","key":"10.3233\/JHD-180332_ref15","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S1474-4422(14)70238-8","article-title":"Prediction of manifest Huntington\u2019s disease with clinical and imaging measures: A prospective observational study","volume":"13","author":"JS","year":"2014","journal-title":"Lancet Neurol"},{"issue":"4","key":"10.3233\/JHD-180332_ref16","doi-asserted-by":"crossref","first-page":"477","DOI":"10.3233\/JHD-130076","article-title":"Regional atrophy associated with cognitive and motor function in prodromal Huntington disease","volume":"2","author":"EH","year":"2013","journal-title":"J Huntingtons Dis"},{"issue":"2","key":"10.3233\/JHD-180332_ref17","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1017\/S1355617716001132","article-title":"Cognitive control, learning, and clinical motor ratings are most highly associated with basal ganglia brain volumes in the premanifest Huntington\u2019s disease phenotype","volume":"23","author":"MB","year":"2017","journal-title":"J Int Neuropsychol Soc"},{"issue":"3","key":"10.3233\/JHD-180332_ref18","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1089\/brain.2017.0538","article-title":"Whole-brain connectivity in a large study of Huntington\u2019s disease gene mutation carriers and healthy controls","volume":"8","author":"FA","year":"2018","journal-title":"Brain Connect"},{"issue":"9","key":"10.3233\/JHD-180332_ref19","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","article-title":"Biological and clinical manifestations of Huntington\u2019s disease in the longitudinal TRACK-HD study: Cross-sectional analysis of baseline data","volume":"8","author":"SJ","year":"2009","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.3233\/JHD-180332_ref20","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1474-4422(10)70276-3","article-title":"Biological and clinical changes in premanifest and early stage Huntington\u2019s disease in the TRACK-HD study: The 12-month longitudinal analysis","volume":"10","author":"SJ","year":"2011","journal-title":"Lancet Neurol"},{"issue":"1","key":"10.3233\/JHD-180332_ref21","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S1474-4422(11)70263-0","article-title":"Potential endpoints for clinical trials in premanifest and early Huntington\u2019s disease in the TRACK-HD study: Analysis of 24 month observational data","volume":"11","author":"SJ","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.3233\/JHD-180332_ref22","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.nicl.2016.02.014","article-title":"Linking white matter and deep gray matter alterations in premanifest Huntington disease","volume":"11","author":"AV","year":"2016","journal-title":"Neuroimage Clin"},{"issue":"10","key":"10.3233\/JHD-180332_ref23","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1002\/hbm.23713","article-title":"Mapping the order and pattern of brain structural MRI changes using change-point analysis in premanifest Huntington\u2019s disease","volume":"38","author":"D","year":"2017","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JHD-180332_ref24","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.nbd.2014.01.013","article-title":"White matter connectivity reflects clinical and cognitive status in Huntington\u2019s disease","volume":"65","author":"GR","year":"2014","journal-title":"Neurobiol Dis"},{"issue":"3","key":"10.3233\/JHD-180332_ref25","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1002\/hbm.23465","article-title":"Longitudinal diffusion changes in prodromal and early HD: Evidence of white-matter tract deterioration","volume":"38","author":"JJ","year":"2017","journal-title":"Hum Brain Mapp"},{"issue":"12","key":"10.3233\/JHD-180332_ref26","doi-asserted-by":"crossref","first-page":"4615","DOI":"10.1002\/hbm.23332","article-title":"Natural variation in sensory-motor white matter organization influences manifestations of Huntington\u2019s disease","volume":"37","author":"M","year":"2016","journal-title":"Hum Brain Mapp"},{"issue":"3-4","key":"10.3233\/JHD-180332_ref27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.brainresbull.2010.04.003","article-title":"Striatal and white matter predictors of estimated diagnosis for Huntington disease","volume":"82","author":"JS","year":"2010","journal-title":"Brain Res Bull"},{"issue":"1","key":"10.3233\/JHD-180332_ref28","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.biopsych.2005.06.003","article-title":"Brain structure in preclinical Huntington\u2019s disease","volume":"59","author":"JS","year":"2006","journal-title":"Biol Psychiatry"},{"issue":"4","key":"10.3233\/JHD-180332_ref29","doi-asserted-by":"crossref","first-page":"517","DOI":"10.3233\/JHD-130077","article-title":"Corpus callosal atrophy in premanifest and early Huntington\u2019s disease","volume":"2","author":"HE","year":"2013","journal-title":"J Huntingtons Dis"},{"issue":"1","key":"10.3233\/JHD-180332_ref30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11682-008-9051-2","article-title":"Diffusion tensor imaging in preclinical Huntington\u2019s disease","volume":"3","author":"VA","year":"2009","journal-title":"Brain Imaging Behav"},{"issue":"9","key":"10.3233\/JHD-180332_ref31","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1002\/mds.20979","article-title":"Diffusion tensor imaging in presymptomatic and early Huntington\u2019s disease: Selective white matter pathology and its relationship to clinical measures","volume":"21","author":"HD","year":"2006","journal-title":"Mov Disord"},{"issue":"15","key":"10.3233\/JHD-180332_ref32","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1212\/WNL.0b013e3181d8c20a","article-title":"Contrasting gray and white matter changes in preclinical Huntington disease: An MRI study","volume":"74","author":"D","year":"2010","journal-title":"Neurology"},{"issue":"11","key":"10.3233\/JHD-180332_ref33","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1002\/mds.26803","article-title":"Cross-sectional and longitudinal multimodal structural imaging in prodromal Huntington\u2019s disease","volume":"31","author":"DL","year":"2016","journal-title":"Mov Disord"},{"issue":"10","key":"10.3233\/JHD-180332_ref34","doi-asserted-by":"crossref","first-page":"e109676","DOI":"10.1371\/journal.pone.0109676","article-title":"Deep white matter in Huntington\u2019s disease","volume":"9","author":"O","year":"2014","journal-title":"PLoS One"},{"issue":"9","key":"10.3233\/JHD-180332_ref35","doi-asserted-by":"crossref","first-page":"e73280","DOI":"10.1371\/journal.pone.0073280","article-title":"Tractography of the corpus callosum in Huntington\u2019s disease","volume":"8","author":"O","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.3233\/JHD-180332_ref36","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1002\/hbm.22273","article-title":"Diffusion weighted imaging of prefrontal cortex in prodromal Huntington\u2019s disease","volume":"35","author":"JT","year":"2014","journal-title":"Hum Brain Mapp"},{"issue":"4","key":"10.3233\/JHD-180332_ref37","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1136\/jnnp.2010.208264","article-title":"Longitudinal change in regional brain volumes in prodromal Huntington disease","volume":"82","author":"EH","year":"2011","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JHD-180332_ref38","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.nbd.2014.12.009","article-title":"Longitudinal change in white matter microstructure in Huntington\u2019s disease: The IMAGE-HD study","volume":"74","author":"GR","year":"2015","journal-title":"Neurobiol Dis"},{"issue":"6","key":"10.3233\/JHD-180332_ref39","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1002\/hbm.22756","article-title":"Microstructural brain abnormalities in Huntington\u2019s disease: A two-year follow-up","volume":"36","author":"OF","year":"2015","journal-title":"Hum Brain Mapp"},{"issue":"10","key":"10.3233\/JHD-180332_ref40","doi-asserted-by":"crossref","first-page":"3717","DOI":"10.1002\/hbm.22835","article-title":"Prefrontal cortex white matter tracts in prodromal Huntington disease","volume":"36","author":"JT","year":"2015","journal-title":"Hum Brain Mapp"},{"issue":"2","key":"10.3233\/JHD-180332_ref41","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/arclin\/acs105","article-title":"Measuring executive dysfunction longitudinally and in relation to genetic burden, brain volumetrics, and depression in prodromal Huntington disease","volume":"28","author":"KV","year":"2013","journal-title":"Arch Clin Neuropsychol"},{"issue":"3","key":"10.3233\/JHD-180332_ref42","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1002\/hbm.20540","article-title":"Source-based morphometry: The use of independent component analysis to identify gray matter differences with application to schizophrenia","volume":"30","author":"L","year":"2009","journal-title":"Hum Brain Mapp"},{"key":"10.3233\/JHD-180332_ref43","first-page":"13","article-title":"Nipype: A flexible, lightweight and extensible neuroimaging data processing framework in python","volume":"5","author":"K","year":"2011","journal-title":"Front Neuroinform"},{"issue":"3","key":"10.3233\/JHD-180332_ref44","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"BB","year":"2011","journal-title":"Neuroimage"},{"key":"10.3233\/JHD-180332_ref45","first-page":"29","article-title":"Robust multi-site MR data processing: Iterative optimization of bias correction, tissue classification, and registration","volume":"7","author":"E","year":"2013","journal-title":"Front Neuroinform"},{"key":"10.3233\/JHD-180332_ref46","doi-asserted-by":"crossref","first-page":"97841V","DOI":"10.1117\/12.2216625","article-title":"Tissue classification of large-scale multi-site MR data using fuzzy k-nearest neighbor method","volume":"9784","author":"A","year":"2016","journal-title":"Proc SPIE Med Imaging"},{"key":"10.3233\/JHD-180332_ref47","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.neuroimage.2017.04.012","article-title":"Robust automated constellation-based landmark detection in human brain imaging","volume":"170","author":"A","year":"2018","journal-title":"Neuroimage"},{"key":"10.3233\/JHD-180332_ref48","unstructured":"Wechsler D . Manual for the Wechsler Adult Intelligence Scale. Oxford, England: Psychological Corporation; 1955."},{"key":"10.3233\/JHD-180332_ref49","volume-title":"Symbol Digit Modalities Test (SDMT) Manual (Revised)","author":"A","year":"1982"},{"issue":"6","key":"10.3233\/JHD-180332_ref50","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1037\/h0054651","article-title":"Studies of interference in serial verbal reactions.","volume":"18","author":"JR","year":"1935","journal-title":"J Exp Psychol"},{"issue":"5","key":"10.3233\/JHD-180332_ref51","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1080\/13803395.2010.541228","article-title":"The Trail Making Test in prodromal Huntington disease: Contributions of disease progression to test performance","volume":"33","author":"JJ","year":"2011","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.3233\/JHD-180332_ref52","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2466\/pms.1958.8.3.271","article-title":"Validity of the trail making test as an indicator of organic brain damage","volume":"8","author":"Reitan","year":"1958","journal-title":"Percept Mot Skills"},{"key":"10.3233\/JHD-180332_ref53","unstructured":"Genetic Modifiers of Huntington\u2019s Disease (GeM-HD) Consortium. Identification of genetic factors that modify clinical onset of Huntington\u2019s disease. Cell. 2015;162(3):516\u201326."},{"issue":"5","key":"10.3233\/JHD-180332_ref54","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1093\/schbul\/sbu177","article-title":"Patterns of gray matter abnormalities in schizophrenia based on an international mega-analysis","volume":"41","author":"CN","year":"2015","journal-title":"Schizophr Bull"},{"key":"10.3233\/JHD-180332_ref55","first-page":"10","article-title":"Correspondence between structure and function in the human brain at rest","volume":"6","author":"JM","year":"2012","journal-title":"Front Neuroinform"},{"issue":"11","key":"10.3233\/JHD-180332_ref56","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/hbm.20359","article-title":"Estimating the number of independent components for functional magnetic resonance imaging data","volume":"28","author":"YO","year":"2007","journal-title":"Hum Brain Mapp"},{"issue":"3","key":"10.3233\/JHD-180332_ref57","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.neuroimage.2004.03.027","article-title":"Validating the independent components of neuroimaging time series via clustering and visualization","volume":"22","author":"J","year":"2004","journal-title":"Neuroimage"},{"issue":"12","key":"10.3233\/JHD-180332_ref58","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1109\/TBME.2011.2167149","article-title":"Automatic identification of functional clusters in FMRI data using spatial dependence","volume":"58","author":"S","year":"2011","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.3233\/JHD-180332_ref59","doi-asserted-by":"crossref","unstructured":"Verbeke G , Molenberghs G . Linear Mixed Models for Longitudinal Data. New York: Springer; 2000.","DOI":"10.1007\/978-1-4419-0300-6"},{"key":"10.3233\/JHD-180332_ref60","unstructured":"Long JD . Longitudinal Data Analysis for the Behavioral Sciences Using R. Thousand Oaks, California: SAGE Publications, Inc.; 2011."},{"issue":"2","key":"10.3233\/JHD-180332_ref61","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1468-1331.2012.03854.x","article-title":"Evolution of brain gray matter loss in Huntington\u2019s disease: A meta-analysis","volume":"20","author":"V","year":"2013","journal-title":"Eur J Neurol"},{"issue":"8","key":"10.3233\/JHD-180332_ref62","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/mds.21137","article-title":"Striatal gray matter loss in Huntington\u2019s disease is leftward biased","volume":"22","author":"M","year":"2007","journal-title":"Mov Disord"},{"issue":"10","key":"10.3233\/JHD-180332_ref63","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1016\/j.ebiom.2015.08.002","article-title":"Compensation in preclinical Huntington\u2019s disease: Evidence from the Track-On HD Study","volume":"2","author":"S","year":"2015","journal-title":"EBioMedicine"},{"issue":"12","key":"10.3233\/JHD-180332_ref64","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1001\/archneur.1996.00550120105023","article-title":"Basal ganglia volume and proximity to onset in presymptomatic Huntington disease","volume":"53","author":"EH","year":"1996","journal-title":"Arch Neurol"},{"issue":"1","key":"10.3233\/JHD-180332_ref65","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/ana.410310113","article-title":"Putamen volume reduction on magnetic resonance imaging exceeds caudate changes in mild Huntington\u2019s disease","volume":"31","author":"GJ","year":"1992","journal-title":"Ann Neurol"},{"issue":"7","key":"10.3233\/JHD-180332_ref66","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S1474-4422(13)70088-7","article-title":"Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington\u2019s disease in the TRACK-HD study: Analysis of 36-month observational data","volume":"12","author":"SJ","year":"2013","journal-title":"Lancet Neurol"},{"issue":"7","key":"10.3233\/JHD-180332_ref67","doi-asserted-by":"crossref","first-page":"E116","DOI":"10.3390\/brainsci8070116","article-title":"High and low levels of an NTRK2-driven genetic profile affect motor- and cognition-associated frontal gray matter in prodromal Huntington\u2019s disease","volume":"8","author":"JA","year":"2018","journal-title":"Brain Sci"},{"issue":"4","key":"10.3233\/JHD-180332_ref68","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1093\/brain\/awn025","article-title":"Cerebral cortex and the clinical expression of Huntington\u2019s disease: Complexity and heterogeneity","volume":"131","author":"HD","year":"2008","journal-title":"Brain"},{"issue":"6","key":"10.3233\/JHD-180332_ref69","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1111\/cns.12701","article-title":"Resting-state connectivity and modulated somatomotor and default-mode networks in Huntington disease","volume":"23","author":"C","year":"2017","journal-title":"CNS Neurosci Ther"},{"issue":"6","key":"10.3233\/JHD-180332_ref70","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1002\/hbm.22351","article-title":"Altered resting-state connectivity in Huntington\u2019s disease","volume":"35","author":"CJ","year":"2014","journal-title":"Hum Brain Mapp"},{"issue":"7","key":"10.3233\/JHD-180332_ref71","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1089\/brain.2014.0271","article-title":"Functional connectivity of primary motor cortex is dependent on genetic burden in prodromal Huntington disease","volume":"4","author":"KA","year":"2014","journal-title":"Brain Connect"},{"issue":"6","key":"10.3233\/JHD-180332_ref72","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1365-2990.1997.tb01326.x","article-title":"Significant loss of pyramidal neurons in the angular gyrus of patients with Huntington\u2019s disease","volume":"23","author":"V","year":"1997","journal-title":"Neuropathol Appl Neurobiol"},{"issue":"9","key":"10.3233\/JHD-180332_ref73","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1523\/JNEUROSCI.2636-14.2015","article-title":"Converging structural and functional connectivity of orbitofrontal, dorsolateral prefrontal, and posterior parietal cortex in the human striatum","volume":"35","author":"K","year":"2015","journal-title":"J Neurosci"},{"issue":"6","key":"10.3233\/JHD-180332_ref74","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1212\/01.WNL.0000138434.68093.67","article-title":"In vivo evidence of cerebellar atrophy and cerebral white matter loss in Huntington disease","volume":"63","author":"C","year":"2004","journal-title":"Neurology"},{"issue":"4","key":"10.3233\/JHD-180332_ref75","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1007\/s00415-015-7642-6","article-title":"Abnormal cerebellar volume and corticocerebellar dysfunction in early manifest Huntington\u2019s disease","volume":"262","author":"RC","year":"2015","journal-title":"J Neurol"},{"issue":"13","key":"10.3233\/JHD-180332_ref76","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1002\/mds.25984","article-title":"Cerebellar abnormalities in Huntington\u2019s disease: A role in motor and psychiatric impairment?","volume":"29","author":"EM","year":"2014","journal-title":"Mov Disord"},{"issue":"2","key":"10.3233\/JHD-180332_ref77","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1750-3639.2012.00629.x","article-title":"Degeneration of the cerebellum in Huntington\u2019s disease (HD): Possible relevance for the clinical picture and potential gateway to pathological mechanisms of the disease process","volume":"23","author":"U","year":"2013","journal-title":"Brain Pathol"},{"issue":"8","key":"10.3233\/JHD-180332_ref78","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1016\/j.neuropsychologia.2006.12.023","article-title":"Increased cortical recruitment in Huntington\u2019s disease using a Simon task","volume":"45","author":"N","year":"2007","journal-title":"Neuropsychologia"},{"key":"10.3233\/JHD-180332_ref79","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.parkreldis.2016.04.017","article-title":"Resting-state fMRI reveals potential neural correlates of impaired cognition in Huntington\u2019s disease","volume":"27","author":"W","year":"2016","journal-title":"Parkinsonism Relat Disord"},{"issue":"5","key":"10.3233\/JHD-180332_ref80","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1212\/01.wnl.0000174432.87383.87","article-title":"Regional cortical thinning in preclinical Huntington disease and its relationship to cognition","volume":"65","author":"HD","year":"2005","journal-title":"Neurology"},{"issue":"9","key":"10.3233\/JHD-180332_ref81","first-page":"1553","article-title":"Central motor processing in Huntington\u2019s disease","volume":"120","author":"P","year":"1997","journal-title":"A PET study. Brain"},{"issue":"9","key":"10.3233\/JHD-180332_ref82","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1093\/brain\/120.9.1569","article-title":"Cortical control of movement in Huntington\u2019s disease. A PET activation study","volume":"120","author":"RA","year":"1997","journal-title":"Brain"},{"issue":"6","key":"10.3233\/JHD-180332_ref83","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1007\/s11682-018-9849-5","article-title":"Progressive microstructural changes of the occipital cortex in Huntington\u2019s disease","volume":"12","author":"OFF","year":"2018","journal-title":"Brain Imaging Behav"},{"key":"10.3233\/JHD-180332_ref84","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jneumeth.2014.04.023","article-title":"Exploration of scanning effects in multi-site structural MRI studies","volume":"230","author":"J","year":"2014","journal-title":"J Neurosci Methods"},{"issue":"6","key":"10.3233\/JHD-180332_ref85","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1089\/brain.2012.0112","article-title":"Multicenter reliability of diffusion tensor imaging","volume":"2","author":"VA","year":"2012","journal-title":"Brain Connect"}],"container-title":["Journal of Huntington's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JHD-180332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:50:46Z","timestamp":1777452646000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JHD-180332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,30]]},"references-count":85,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jhd-180332","relation":{},"ISSN":["1879-6397","1879-6400"],"issn-type":[{"value":"1879-6397","type":"print"},{"value":"1879-6400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,30]]}}}