{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:28:27Z","timestamp":1791224907044,"version":"4.1.0"},"reference-count":49,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHD"],"published-print":{"date-parts":[[2020,2,10]]},"DOI":"10.3233\/jhd-190375","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T11:50:37Z","timestamp":1576842637000},"page":"69-81","source":"Crossref","is-referenced-by-count":31,"title":["A Longitudinal Wearable Sensor Study in Huntington\u2019s Disease"],"prefix":"10.1177","volume":"9","author":[{"given":"Karthik","family":"Dinesh","sequence":"first","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher W.","family":"Snyder","sequence":"additional","affiliation":[{"name":"Center for Health + Technology, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulin","family":"Xiong","sequence":"additional","affiliation":[{"name":"Michigan State University College of Human Medicine, East Lansing, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Tarolli","sequence":"additional","affiliation":[{"name":"Center for Health + Technology, University of Rochester Medical Center, Rochester, NY, USA"},{"name":"Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saloni","family":"Sharma","sequence":"additional","affiliation":[{"name":"Center for Health + Technology, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. Ray","family":"Dorsey","sequence":"additional","affiliation":[{"name":"Center for Health + Technology, University of Rochester Medical Center, Rochester, NY, USA"},{"name":"Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Electrical and Computer Engineering, University of Rochester, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie L.","family":"Adams","sequence":"additional","affiliation":[{"name":"Center for Health + Technology, University of Rochester Medical Center, Rochester, NY, USA"},{"name":"Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JHD-190375_ref1","doi-asserted-by":"publisher","first-page":"c3109","DOI":"10.1136\/bmj.c3109","article-title":"Huntington\u2019s disease","volume":"340","author":"Novak","year":"2010","journal-title":"BMJ"},{"key":"10.3233\/JHD-190375_ref2","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S1474-4422(10)70245-3","article-title":"Huntington\u2019s disease: From molecular pathogenesis to clinical treatment","volume":"10","author":"Ross","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.3233\/JHD-190375_ref3","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1002\/mds.870110204","article-title":"Unified Huntington\u2019s disease rating scale: Reliability and consistency","volume":"11","author":"Kieburtz","year":"1996","journal-title":"Mov Disord"},{"key":"10.3233\/JHD-190375_ref4","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1159\/000477383","article-title":"The first frontier: Digital biomarkers for neurodegenerative disorders","volume":"1","author":"Dorsey","year":"2017","journal-title":"Digit Biomark"},{"key":"10.3233\/JHD-190375_ref5","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1016\/B978-0-12-801893-4.00018-3","article-title":"Motor outcome measures in Huntington disease clinical trials","volume":"144","author":"Reilmann","year":"2017","journal-title":"Handb Clin Neurol"},{"key":"10.3233\/JHD-190375_ref6","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1109\/TBME.2012.2183367","article-title":"Novel speech signal processing algorithms for high-accuracy classification of Parkinsons disease","volume":"59","author":"Tsanas","year":"2012","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.3233\/JHD-190375_ref7","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.gaitpost.2018.03.047","article-title":"Identifying balance impairments in people with Parkinson\u2019s disease using video and wearable sensors","volume":"62","author":"Stack","year":"2018","journal-title":"Gait Posture"},{"key":"10.3233\/JHD-190375_ref8","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.1002\/mds.21561","article-title":"Video analysis of motor events in REM sleep behavior disorder","volume":"22","author":"Frauscher","year":"2007","journal-title":"Mov Disord"},{"key":"10.3233\/JHD-190375_ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0183989"},{"key":"10.3233\/JHD-190375_ref10","doi-asserted-by":"publisher","first-page":"30942","DOI":"10.1109\/ACCESS.2018.2840327","article-title":"Meta-classifiers in Huntington\u2019s disease patients classification, using iPhone\u2019s movement sensors placed at the ankles","volume":"6","author":"Acosta-Escalante","year":"2018","journal-title":"IEEE Access"},{"key":"10.3233\/JHD-190375_ref11","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1016\/j.parkreldis.2015.02.026","article-title":"Detecting and monitoring the symptoms of Parkinson\u2019s disease using smartphones: A pilot study","volume":"21","author":"Arora","year":"2015","journal-title":"Parkinsonism Relat Disord"},{"key":"10.3233\/JHD-190375_ref12","doi-asserted-by":"publisher","first-page":"134","DOI":"10.3390\/s16010134","article-title":"A machine learning framework for gait classification using inertial sensors: Application to elderly, post-stroke and Huntington\u2019s disease patients","volume":"16","author":"Mannini","year":"2016","journal-title":"Sensors"},{"key":"10.3233\/JHD-190375_ref13","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1016\/j.gaitpost.2015.06.008","article-title":"Comparative assessment of different methods for the estimation of gait temporal parameters using a single inertial sensor: Application to elderly, post-stroke, Parkinson\u2019s disease and Huntington\u2019s disease subjects","volume":"42","author":"Trojaniello","year":"2015","journal-title":"Gait Posture"},{"key":"10.3233\/JHD-190375_ref14","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/j.gaitpost.2018.03.039","article-title":"Objective assessment of gait and posture in premanifest and manifest Huntington disease \u2014 A multi-center study","volume":"62","author":"Beckmann","year":"2018","journal-title":"Gait Posture"},{"key":"10.3233\/JHD-190375_ref15","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1016\/j.jns.2017.02.054","article-title":"Quantitative biomechanical assessment of trunk control in Huntington\u2019s disease reveals more impairment in static than dynamic tasks","volume":"376","author":"Kegelmeyer","year":"2017","journal-title":"J Neurol Sci"},{"key":"10.3233\/JHD-190375_ref16","doi-asserted-by":"publisher","first-page":"637","DOI":"10.1016\/S1474-4422(13)70088-7","article-title":"Predictors of phenotypic progression and disease onset in premanifest and early-stage Huntington\u2019s disease in the TRACK-HD study: Analysis of 36-month observational data","volume":"12","author":"Tabrizi","year":"2013","journal-title":"Lancet Neurol"},{"key":"10.3233\/JHD-190375_ref17","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/S1474-4422(11)70263-0","article-title":"Potential endpoints for clinical trials in premanifest and early Huntington\u2019s disease in the TRACK-HD study: Analysis of 24 month observational data","volume":"11","author":"Tabrizi","year":"2012","journal-title":"Lancet Neurol"},{"key":"10.3233\/JHD-190375_ref18","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S1474-4422(10)70276-3","article-title":"Biological and clinical changes in premanifest and early stage Huntington\u2019s disease in the TRACK-HD study: The 12-month longitudinal analysis","volume":"10","author":"Tabrizi","year":"2011","journal-title":"Lancet Neurol"},{"key":"10.3233\/JHD-190375_ref19","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","article-title":"Biological and clinical manifestations of Huntington\u2019s disease in the longitudinal TRACK-HD study: Cross-sectional analysis of baseline data","volume":"8","author":"Tabrizi","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.3233\/JHD-190375_ref20","doi-asserted-by":"publisher","first-page":"2267","DOI":"10.1002\/mds.23816","article-title":"Assessment of involuntary choreatic movements in Huntington\u2019s disease-Toward objective and quantitative measures","volume":"26","author":"Reilmann","year":"2011","journal-title":"Mov Disord"},{"key":"10.3233\/JHD-190375_ref21","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3233\/JHD-160197","article-title":"Wearable sensors in Huntington disease: A pilot study","volume":"2016","author":"Andrzejewski","journal-title":"J Huntingtons Dis"},{"key":"10.3233\/JHD-190375_ref22","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1159\/000479018","article-title":"Multiple wearable sensors in parkinson and huntington disease individuals: A pilot study in clinic and at home","volume":"1","author":"Adams","year":"2017","journal-title":"Digit Biomark"},{"key":"10.3233\/JHD-190375_ref24","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1111\/j.1532-5415.2005.53221.x","article-title":"The montreal cognitive assessment, MoCA: A brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JHD-190375_ref25","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/j.1532-5415.1991.tb01616.x","article-title":"The Timed \u201cUp & Go\u201d: A test of basic functional mobility for frail elderly persons","volume":"39","author":"Richardson","year":"1991","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JHD-190375_ref26","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.gaitpost.2016.11.033","article-title":"Are the average gait speeds during the 10meter and 6minute walk tests redundant in Parkinson disease?","volume":"52","author":"Duncan","year":"2017","journal-title":"Gait Posture"},{"key":"10.3233\/JHD-190375_ref27","doi-asserted-by":"publisher","first-page":"P474","DOI":"10.1055\/s-0029-1238568","article-title":"A teaching film, video library and online certification for the unified huntington\u2019s disease rating scale total motor score","volume":"36","author":"Reilmann","year":"2009","journal-title":"Aktuelle Neurol"},{"key":"10.3233\/JHD-190375_ref28","unstructured":"Oppenheim A V. , Schafer RW. Discrete-time signal processing. 3rd ed. Pearson; 2014."},{"key":"10.3233\/JHD-190375_ref29","doi-asserted-by":"publisher","first-page":"1054","DOI":"10.1109\/LSP.2013.2278339","article-title":"A direct algorithm for 1-D total variation denoising","volume":"20","author":"Condat","year":"2013","journal-title":"IEEE Signal Process Lett"},{"key":"10.3233\/JHD-190375_ref30","doi-asserted-by":"publisher","DOI":"10.1109\/WNYIPW.2016.7904834"},{"key":"10.3233\/JHD-190375_ref31","doi-asserted-by":"publisher","first-page":"273","DOI":"10.5081\/jgps.3.1.273","article-title":"A step, stride and heading determination for the pedestrian navigation system","volume":"3","author":"Kim","year":"2004","journal-title":"J Glob Position Syst"},{"key":"10.3233\/JHD-190375_ref32","unstructured":"West BT , Welch KB , Ga\u0131ecki AT , Gillespie BW . Linear mixed models: A practical guide using statistical software. Chapman and Hall\/CRC."},{"key":"10.3233\/JHD-190375_ref33","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/BF00140873","article-title":"Unconstrained parametrizations for variance-covariance matrices","volume":"6","author":"Pinheiro","year":"1996","journal-title":"Stat Comput"},{"key":"10.3233\/JHD-190375_ref34","doi-asserted-by":"crossref","unstructured":"Gibbons JD , Chakraborti S . Nonparametric statistical inference. 5th Ed. Chapman & Hall\/Taylor & Francis; 2011.","DOI":"10.1007\/978-3-642-04898-2_420"},{"key":"10.3233\/JHD-190375_ref35","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1001\/jamaneurol.2018.0809","article-title":"Using smartphones and machine learning to quantify Parkinson disease severity","volume":"75","author":"Zhan","year":"2018","journal-title":"JAMA Neurol"},{"key":"10.3233\/JHD-190375_ref36","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1176\/jnp.17.4.496","article-title":"Depression and stages of Huntington\u2019s disease","volume":"17","author":"Paulsen","year":"2005","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.3233\/JHD-190375_ref37","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1523\/JNEUROSCI.3842-04.2005","article-title":"Disintegration of the sleep-wake cycle and circadian timing in Huntington\u2019s disease","volume":"25","author":"Morton","year":"2005","journal-title":"J Neurosci"},{"key":"10.3233\/JHD-190375_ref38","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1177\/1358863X15626521","article-title":"Community walking speed, sedentary or lying down time, and mortality in peripheral artery disease","volume":"21","author":"McDermott","year":"2016","journal-title":"Vasc Med"},{"key":"10.3233\/JHD-190375_ref39","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1007\/s10654-014-9939-7","article-title":"Hours lying down per day and mortality from all-causes and cardiovascular disease: The HUNT Study, Norway","volume":"29","author":"Holtermann","year":"2014","journal-title":"Eur J Epidemiol"},{"key":"10.3233\/JHD-190375_ref40","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1136\/jnnp.2008.147793","article-title":"Mobility and falls in people with Huntington\u2019s disease","volume":"80","author":"Busse","year":"2009","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.3233\/JHD-190375_ref41","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1002\/mds.27376","article-title":"Evaluation of smartphone-based testing to generate exploratory outcome measures in a phase 1 Parkinson\u2019s disease clinical trial","volume":"33","author":"Lipsmeier","year":"2018","journal-title":"Mov Disord"},{"key":"10.3233\/JHD-190375_ref42","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1519\/00139143-200932020-00002","article-title":"White paper: \u201cwalking speed: The sixth vital sign\u201d","volume":"32","author":"Fritz","year":"2009","journal-title":"J Geriatr Phys Ther"},{"key":"10.3233\/JHD-190375_ref43","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1123\/japa.2013-0236","article-title":"Walking speed: The functional vital sign","volume":"23","author":"Middleton","year":"2015","journal-title":"J Aging Phys Act"},{"key":"10.3233\/JHD-190375_ref44","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1001\/jama.2010.1923","article-title":"Gait speed and survival in older adults","volume":"305","author":"Studenski","year":"2011","journal-title":"JAMA"},{"key":"10.3233\/JHD-190375_ref45","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1093\/gerona\/gls197","article-title":"Trajectories of gait speed predict mortality in well-functioning older adults: The Health, Aging and Body Composition study","volume":"68","author":"White","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.3233\/JHD-190375_ref46","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1111\/j.1532-5415.2007.01413.x","article-title":"Improvement in usual gait speed predicts better survival in older adults","volume":"55","author":"Hardy","year":"2007","journal-title":"J Am Geriatr Soc"},{"key":"10.3233\/JHD-190375_ref47","doi-asserted-by":"publisher","first-page":"1734","DOI":"10.2522\/ptj.20150662","article-title":"Objective gait and balance impairments relate to balance confidence and perceived mobility in people with Parkinson disease","volume":"96","author":"Curtze","year":"2016","journal-title":"Phys Ther"},{"key":"10.3233\/JHD-190375_ref48","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124763"},{"key":"10.3233\/JHD-190375_ref49","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39695-0"},{"key":"10.3233\/JHD-190375_ref50","doi-asserted-by":"publisher","first-page":"582","DOI":"10.1001\/jamaneurol.2014.4524","article-title":"Novel methods and technologies for 21st-century clinical trials: A review","volume":"72","author":"Dorsey","year":"2015","journal-title":"JAMA Neurol"}],"container-title":["Journal of Huntington's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JHD-190375","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:50:58Z","timestamp":1777452658000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JHD-190375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,10]]},"references-count":49,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jhd-190375","relation":{},"ISSN":["1879-6397","1879-6400"],"issn-type":[{"value":"1879-6397","type":"print"},{"value":"1879-6400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,10]]}}}