{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:54:12Z","timestamp":1790830452125,"version":"4.1.0"},"reference-count":50,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T00:00:00Z","timestamp":1602115200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHD"],"published-print":{"date-parts":[[2020,10,8]]},"abstract":"<jats:p>The current dogma of HD pathoetiology posits it is a degenerative disease affecting primarily the striatum, caused by a gain of function (toxicity) of the mutant mHTT that kills neurons. However, a growing body of evidence supports an alternative theory in which loss of function may also influence the pathology.This theory is predicated on the notion that HTT is known to be a vital gene for brain development. mHTT is expressed throughout life and could conceivably have deleterious effects on brain development. The end event in the disease is, of course, neurodegeneration; however the process by which that occurs may be rooted in the pathophysiology of aberrant development. To date, there have been multiple studies evaluating molecular and cellular mechanisms of abnormal development in HD, as well as studies investigating abnormal brain development in HD animal models. However, direct study of how mHTT could affect neurodevelopment in humans has not been approached until recent years. The current review will focus on the most recent findings of a unique study of children at-risk for HD, the Kids-HD study. This study evaluates brain structure and function in children ages 6\u201318 years old who are at risk for HD (have a parent or grand-parent with HD).<\/jats:p>","DOI":"10.3233\/jhd-200394","type":"journal-article","created":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T13:48:41Z","timestamp":1599832121000},"page":"217-229","source":"Crossref","is-referenced-by-count":61,"title":["The Neurodevelopmental Hypothesis of Huntington\u2019s Disease"],"prefix":"10.1177","volume":"9","author":[{"given":"Ellen","family":"van der Plas","sequence":"first","affiliation":[{"name":"University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan L.","family":"Schultz","sequence":"additional","affiliation":[{"name":"University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, IA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peg 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