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In this review, we first discuss evidence from both HD patients and animal models that cognitive changes correlate with early pathological changes at the synapse, an observation that is similarly made in other neurodegenerative conditions that primarily affect cognition. We then describe how autophagy plays a critical role supporting synaptic maintenance in the healthy brain, and how autophagy dysfunction in HD may thereby lead to impaired synaptic maintenance and thus early manifestations of disease.<\/jats:p>","DOI":"10.3233\/jhd-200466","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T14:18:24Z","timestamp":1616509104000},"page":"227-238","source":"Crossref","is-referenced-by-count":10,"title":["Do Changes in Synaptic Autophagy Underlie the Cognitive Impairments in Huntington\u2019s Disease?"],"prefix":"10.1177","volume":"10","author":[{"given":"Hilary","family":"Grosso Jasutkar","sequence":"first","affiliation":[{"name":"Department of Neurology, Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ai","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Neurology, Columbia University, New York, NY, USA"},{"name":"Department of 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