{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:52:17Z","timestamp":1777686737428,"version":"3.51.4"},"reference-count":29,"publisher":"SAGE Publications","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHD"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>Huntington\u2019s disease (HD) is an inherited neurodegenerative disease characterized by motor, cognitive and behavioral deficits. Some evidence suggests that the endocannabinoid system participates in the pathophysiology of HD. We conducted a cross-sectional study comparing plasma levels of anandamide and 2-arachidonoylglycerol in manifest HD gene-expansion carriers (HDGEC) and healthy controls, finding no difference in endocannabinoid levels between the groups. Correlations between endocannabinoid levels and clinical scales (Mini-Mental State Examination, Hospital Anxiety and Depression Scale, Unified Huntington Disease Rating Scale) were non-significant. We found a significant association between body mass index and anandamide levels in healthy controls but not in HDGEC.<\/jats:p>","DOI":"10.3233\/jhd-210507","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T13:53:52Z","timestamp":1643723632000},"page":"91-95","source":"Crossref","is-referenced-by-count":2,"title":["Circulating Endocannabinoids in Huntington\u2019s Disease: An Exploratory Cross-Sectional Study"],"prefix":"10.1177","volume":"11","author":[{"given":"Pedro","family":"Manzke","sequence":"first","affiliation":[{"name":"Hospital de Base do Distrito Federal, Brasilia, Brazil"},{"name":"Department of Neuroscience and Behavior, Ribeir\u00e3o Preto Medical School, University of S\u00e3o Paulo, S\u00e3o Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Alexandre de Souza","family":"Crippa","sequence":"additional","affiliation":[{"name":"Department of Neuroscience and Behavior, Ribeir\u00e3o Preto Medical 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