{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:12:21Z","timestamp":1790647941957,"version":"4.1.0"},"reference-count":25,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHD"],"published-print":{"date-parts":[[2022,3,1]]},"abstract":"<jats:p>Background: Huntington\u2019s disease (HD) commonly presents with impaired social functioning. Specifically, many patients exhibit social withdrawal, or decreased engagement in social activities. Despite the frequency of social withdrawal in HD, no review has been previously published on this subject. Objective: The aim of this study was to conduct a scoping review of social withdrawal in HD. Methods: Two searches were conducted to identify relevant literature. The articles were screened by title and abstract, followed by full text review for all remaining articles. Consistent with scoping review methodology, data extraction focused on identification of broad themes and knowledge gaps. Results: Eight articles were identified that described social withdrawal in HD. Social withdrawal was exhibited by individuals with varying disease severity, and it occurred both within and outside of the home. Social withdrawal was associated with increased caregiver burden, behavioral issues, and psychiatric, cognitive, and physiological changes. Only one case study described an intervention that increased social participation in a previously withdrawn patient. Conclusion: Although social withdrawal is commonly encountered in clinical settings, this review highlights the need for prospective studies to systematically evaluate social withdrawal in HD. These studies should be designed to consider disease stage and associated HD features as well as caregiver burden and potential interventions. Additionally, objective measures of social withdrawal should be used when possible, as existing instruments measure perceptions of participation levels rather than actual withdrawal behavior. Such studies will lay the groundwork to improve social functioning and quality of life for people with HD.<\/jats:p>","DOI":"10.3233\/jhd-210519","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T19:19:10Z","timestamp":1644347950000},"page":"17-24","source":"Crossref","is-referenced-by-count":9,"title":["Social Withdrawal in Huntington\u2019s Disease: A Scoping Review"],"prefix":"10.1177","volume":"11","author":[{"given":"Jessie S.","family":"Gibson","sequence":"first","affiliation":[{"name":"University of Virginia School of Nursing, Charlottesville, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Springer","sequence":"additional","affiliation":[{"name":"University of Virginia School of Education and Human Development, Charlottesville, VA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"issue":"50","key":"10.3233\/JHD-210519_ref1","doi-asserted-by":"crossref","first-page":"9878","DOI":"10.1523\/JNEUROSCI.1138-17.2019","article-title":"The salience network: A neural system for perceiving and responding to homeostatic demands","volume":"39","author":"Seeley","year":"2019","journal-title":"J Neurosci"},{"issue":"1","key":"10.3233\/JHD-210519_ref2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1002\/hbm.24790","article-title":"Aberrant brain network connectivity in presymptomatic and manifest Huntington\u2019s disease: A systematic review","volume":"41","author":"Pini","year":"2020","journal-title":"Hum Brain Mapp"},{"issue":"2","key":"10.3233\/JHD-210519_ref3","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1177\/0193945921992545","article-title":"Perceived effects of neuropsychiatric symptoms on functional status in early-stage Huntington disease","volume":"44","author":"Gibson","year":"2022","journal-title":"West J Nurs Res"},{"issue":"19","key":"10.3233\/JHD-210519_ref4","doi-asserted-by":"crossref","first-page":"e2045","DOI":"10.1212\/WNL.0000000000008906","article-title":"Patient-reported impact of symptoms in Huntington disease: PRISM-HD","volume":"94","author":"Glidden","year":"2020","journal-title":"Neurology"},{"issue":"2","key":"10.3233\/JHD-210519_ref5","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1177\/1745691614568352","article-title":"Loneliness and social isolation as risk factors for mortality: A meta-analytic review","volume":"10","author":"Holt-Lunstad","year":"2015","journal-title":"Perspect Psychol Sci"},{"key":"10.3233\/JHD-210519_ref6","unstructured":"World Health Organization. Constitution of the World Health Organization [Internet]. 1946. Available from: https:\/\/apps.who.int\/gb\/bd\/PDF\/bd47\/EN\/constitution-en.pdf?ua=1."},{"issue":"1","key":"10.3233\/JHD-210519_ref7","doi-asserted-by":"crossref","first-page":"e62","DOI":"10.1016\/S2468-2667(19)30230-0","article-title":"Social disconnectedness, perceived isolation, and symptoms of depression and anxiety among older Americans (NSHAP): A longitudinal mediation analysis","volume":"5","author":"Santini","year":"2020","journal-title":"Lancet Public Health"},{"issue":"8","key":"10.3233\/JHD-210519_ref8","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1177\/0898264312460275","article-title":"Social isolation, loneliness and health among older adults","volume":"24","author":"Coyle","year":"2012","journal-title":"J Aging Health"},{"issue":"4","key":"10.3233\/JHD-210519_ref9","doi-asserted-by":"crossref","first-page":"2102","DOI":"10.1111\/jan.14743","article-title":"Undertaking a scoping review: A practical guide for nursing and midwifery students, clinicians, 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Social supports and physical health: Symptoms, health behaviors, and infectious disease. In: Life-span developmental psychology: Perspectives on stress and coping. Hillsdale, NJ, US: Lawrence Erlbaum Associates, Inc; 1991. pp. 213\u201334."},{"issue":"24","key":"10.3233\/JHD-210519_ref25","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1001\/jama.1997.03540480040036","article-title":"Social ties and susceptibility to the common cold","volume":"277","author":"Cohen","year":"1997","journal-title":"JAMA"}],"container-title":["Journal of Huntington's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JHD-210519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:56:05Z","timestamp":1777452965000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JHD-210519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,1]]},"references-count":25,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3233\/jhd-210519","relation":{},"ISSN":["1879-6397","1879-6400"],"issn-type":[{"value":"1879-6397","type":"print"},{"value":"1879-6400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,1]]}}}