{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:53:04Z","timestamp":1777686784525,"version":"3.51.4"},"reference-count":33,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Huntington's Disease"],"published-print":{"date-parts":[[2022,12,16]]},"abstract":"<jats:p>\n                    A reduced incidence of various forms of cancer has been reported in Huntington\u2019s disease patients and may be due to pro-apoptotic effects of mutant huntingtin. We tested this hypothesis by assessing the effects of huntingtin protein overexpression on survival in two murine cancer models. We generated YAC HD mice containing human huntingtin transgenes with various CAG tract lengths (YAC18, YAC72, YAC128) on either an\n                    <jats:italic toggle=\"yes\">Msh2 or p53<\/jats:italic>\n                    null background which have increased cancer incidence. In both mouse models of cancer, the overexpression of either mutant or wild-type huntingtin had no significant effect on overall survival. These results do not support the hypothesis that mutant huntingtin expression is protective against cancer.\n                  <\/jats:p>","DOI":"10.3233\/jhd-220554","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T10:00:40Z","timestamp":1669370440000},"page":"383-389","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Huntingtin Overexpression Does Not Alter Overall Survival in Murine Cancer Models"],"prefix":"10.1177","volume":"11","author":[{"given":"Laura Lynn","family":"Chan","sequence":"first","affiliation":[{"name":"University of British Columbia","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin","family":"Hill","sequence":"additional","affiliation":[{"name":"University of British Columbia","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Lu","sequence":"additional","affiliation":[{"name":"University of British Columbia","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Van Raamsdonk","sequence":"additional","affiliation":[{"name":"Van Andel Research Institute","place":["USA"]},{"name":"McGill University","place":["Canada"]},{"name":"Research Institute of the McGill University Health Centre","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Randy","family":"Gascoyne","sequence":"additional","affiliation":[{"name":"Center for Lymphoid Cancer","place":["Canada"]},{"name":"University of British Columbia","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael R.","family":"Hayden","sequence":"additional","affiliation":[{"name":"University of British Columbia","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blair R.","family":"Leavitt","sequence":"additional","affiliation":[{"name":"University of British Columbia","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,11,25]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70245-3"},{"issue":"8","key":"e_1_3_3_3_2","first-page":"250","article-title":"Huntington\u2019s chorea","volume":"59","author":"Beighton P","year":"1981","unstructured":"BeightonP, HaydenMR. Huntington\u2019s chorea. S Afr Med J. 1981;59(8):250.","journal-title":"S Afr Med J"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199405193302001"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318249f683"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.003"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.38.7.450"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1086\/318207"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aax3338"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-130082"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000072864"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-e"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.4172\/2157-2518.1000165"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19991001)86:7<1342::AID-CNCR33>3.0.CO;2-3"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.29.12.911"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(12)70132-8"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2016.13"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201201546"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-170263"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djv208"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90319-4"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0995-64"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/70598"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg056"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/356215a0"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1006\/scbi.1996.0035"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.06.005"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2006.08.002"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2007.12.003"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(00)80764-3"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-7-80"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg169"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0590-05.2005"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-180290"}],"container-title":["Journal of Huntington's Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JHD-220554","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JHD-220554","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JHD-220554","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:56:11Z","timestamp":1777452971000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JHD-220554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,25]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,12,16]]}},"alternative-id":["10.3233\/JHD-220554"],"URL":"https:\/\/doi.org\/10.3233\/jhd-220554","relation":{},"ISSN":["1879-6397","1879-6400"],"issn-type":[{"value":"1879-6397","type":"print"},{"value":"1879-6400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,25]]}}}