{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:09:47Z","timestamp":1792454987834,"version":"4.5.0"},"reference-count":12,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHD"],"published-print":{"date-parts":[[2022,12,16]]},"abstract":"<jats:p>\u00a0In this edition of the Huntington\u2019s Disease Clinical Trials Corner, we expand on the PIVOT HD (PTC518), and SIGNAL (pepinemab) trials, and list all currently registered and ongoing clinical trials in Huntington\u2019s disease. We also introduce a \u2018breaking news\u2019 section highlighting recent updates about the SELECT HD, uniQure AMT-130, and VIBRANT HD clinical trials.<\/jats:p>","DOI":"10.3233\/jhd-229006","type":"journal-article","created":{"date-parts":[[2022,12,2]],"date-time":"2022-12-02T10:43:43Z","timestamp":1669977823000},"page":"351-367","source":"Crossref","is-referenced-by-count":24,"title":["Huntington\u2019s Disease Clinical Trials Corner: November 2022"],"prefix":"10.1177","volume":"11","author":[{"given":"Carlos","family":"Estevez-Fraga","sequence":"first","affiliation":[{"name":"Huntington\u2019s Disease Centre, UCL Queen Square Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah J.","family":"Tabrizi","sequence":"additional","affiliation":[{"name":"Huntington\u2019s Disease Centre, UCL Queen Square Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J.","family":"Wild","sequence":"additional","affiliation":[{"name":"Huntington\u2019s Disease Centre, UCL Queen Square Institute of Neurology, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JHD-229006_ref2","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1038\/s41591-022-01919-8","article-title":"Pepinemab antibody blockade of SEMA4D in early Huntington\u2019s disease: A randomized, placebo-controlled, phase 2 trial","volume":"28","author":"Feigin","year":"2022","journal-title":"Nat Med"},{"key":"10.3233\/JHD-229006_ref3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3233\/JHD-170262","article-title":"Clinical Trials Corner: September 2017","volume":"6","author":"Rodrigues","year":"2017","journal-title":"J Huntingtons Dis"},{"key":"10.3233\/JHD-229006_ref8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-27157-z","article-title":"Small molecule splicing modifiers with systemic HTT-lowering activity","volume":"12","author":"Bhattacharyya","year":"2021","journal-title":"Nat Commun"},{"key":"10.3233\/JHD-229006_ref10","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1021\/pr0700753","article-title":"Proteomic profiling of plasma in Huntington\u2019s disease reveals neuroinflammatory activation and biomarker candidates","volume":"6","author":"Dalrymple","year":"2007","journal-title":"J Proteome Res"},{"key":"10.3233\/JHD-229006_ref12","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.nbd.2015.01.002","article-title":"Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease","volume":"76","author":"Southwell","year":"2015","journal-title":"Neurobiol Dis"},{"key":"10.3233\/JHD-229006_ref14","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/s41467-022-28653-6","article-title":"An orally available, brain penetrant, small molecule lowers huntingtin levels by enhancing pseudoexon inclusion","volume":"13","author":"Gubser Keller","year":"2022","journal-title":"Nat Commun"},{"key":"10.3233\/JHD-229006_ref18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3233\/JHD-189001","article-title":"Huntington\u2019s Disease Clinical Trials Corner: February 2018","volume":"7","author":"Rodrigues","year":"2018","journal-title":"J Huntingtons Dis"},{"key":"10.3233\/JHD-229006_ref19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3233\/JHD-189003","article-title":"Huntington\u2019s Disease Clinical Trials Corner: August 2018","volume":"7","author":"Rodrigues","year":"2018","journal-title":"J Huntingtons Dis"},{"key":"10.3233\/JHD-229006_ref20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3233\/JHD-190001","article-title":"Huntington\u2019s Disease Clinical Trials Corner: January 2019","volume":"8","author":"Rodrigues","year":"2019","journal-title":"J Huntingtons Dis"},{"key":"10.3233\/JHD-229006_ref21","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3233\/JHD-199003","article-title":"Huntington\u2019s disease clinical trials corner: June 2019","volume":"8","author":"Rodrigues","year":"2019","journal-title":"J Huntingtons Dis"},{"key":"10.3233\/JHD-229006_ref22","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3233\/JHD-200002","article-title":"Huntington\u2019s Disease Clinical Trials Corner: April 2020","volume":"9","author":"Rodrigues","year":"2020","journal-title":"J Huntingtons Dis"},{"key":"10.3233\/JHD-229006_ref23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3233\/JHD-229002","article-title":"Huntington\u2019s Disease Clinical Trials Corner: April 2022","volume":"11","author":"Estevez-Fraga","year":"2022","journal-title":"J Huntingtons Dis"}],"container-title":["Journal of Huntington's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JHD-229006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:56:12Z","timestamp":1777452972000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JHD-229006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,16]]},"references-count":12,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3233\/jhd-229006","relation":{},"ISSN":["1879-6397","1879-6400"],"issn-type":[{"value":"1879-6397","type":"print"},{"value":"1879-6400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,16]]}}}