{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:53:38Z","timestamp":1777686818345,"version":"3.51.4"},"reference-count":107,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:00:00Z","timestamp":1696291200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHD"],"published-print":{"date-parts":[[2023,10,3]]},"abstract":"<jats:p>Background: Metabolic alterations contribute to disease onset and prognosis of Huntington\u2019s disease (HD). Weight loss in the R6\/2 mouse model of HD is a consistent feature, with onset in mid-to-late stage of disease. Objective: In the present study, we aimed to investigate molecular and functional changes in white adipose tissue (WAT) that occur at weight loss in R6\/2 mice. We further elaborated on the effect of leptin-deficiency and early obesity in R6\/2 mice. Methods: We performed analyses at 12 weeks of age; a time point that coincides with the start of weight loss in our R6\/2 mouse colony. Gonadal (visceral) and inguinal (subcutaneous) WAT depot weights were monitored, as well as adipocyte size distribution. Response to isoprenaline-stimulated glycerol release and insulin-stimulated glucose uptake in adipocytes from gonadal WAT was assessed. Results: In R6\/2 mice, WAT depot weights were comparable to wildtype (WT) mice, and the response to insulin and isoprenaline in gonadal adipocytes was unaltered. Leptin-deficient R6\/2 mice exhibited distinct changes compared to leptin-deficient WT mice. At 12 weeks, female leptin-deficient R6\/2 mice had reduced body weight accompanied by an increased proportion of smaller adipocytes, while in contrast; male mice displayed a shift towards larger adipocyte sizes without a significant body weight reduction at this timepoint. Conclusions: We here show that there are early sex-specific changes in adipocyte cell size distribution in WAT of R6\/2 mice and leptin-deficient R6\/2 mice.<\/jats:p>","DOI":"10.3233\/jhd-230587","type":"journal-article","created":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T13:43:58Z","timestamp":1694526238000},"page":"253-266","source":"Crossref","is-referenced-by-count":0,"title":["Altered Adipocyte Cell Size Distribution Prior to Weight Loss in the R6\/2 Model of Huntington\u2019s Disease"],"prefix":"10.1177","volume":"12","author":[{"given":"Elna","family":"Dickson","sequence":"first","affiliation":[{"name":"Brain Disease Biomarker Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claes","family":"Fryklund","sequence":"additional","affiliation":[{"name":"Glucose Transport and Protein Trafficking, Department of Experimental Medical Science, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"Soylu-Kucharz","sequence":"additional","affiliation":[{"name":"Brain Disease Biomarker Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Sj\u00f6gren","sequence":"additional","affiliation":[{"name":"Brain Disease Biomarker Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin G.","family":"Stenkula","sequence":"additional","affiliation":[{"name":"Glucose Transport and Protein Trafficking, Department of Experimental Medical Science, Lund University, Lund, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Bj\u00f6rkqvist","sequence":"additional","affiliation":[{"name":"Brain 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