{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T01:54:02Z","timestamp":1777686842473,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHD"],"published-print":{"date-parts":[[2023,12,15]]},"abstract":"<jats:p>The term \u201csenile chorea\u201d was previously used to describe cases of insidious onset chorea in elderly patients who lacked family history of chorea. However, many of these patients have an identifiable etiology for their chorea. In this article, we discuss a case of generalized, insidious onset chorea in an 89-year-old man and apply a systematic diagnostic approach to chorea in the elderly to arrive at a diagnosis of late-onset Huntington\u2019s disease. He is to our knowledge the second oldest case of late-onset Huntington\u2019s disease reported in the literature and his case lends support to the expanding phenotype of Huntington\u2019s disease.<\/jats:p>","DOI":"10.3233\/jhd-230596","type":"journal-article","created":{"date-parts":[[2023,12,8]],"date-time":"2023-12-08T13:45:32Z","timestamp":1702043132000},"page":"377-380","source":"Crossref","is-referenced-by-count":0,"title":["Chorea in the Elderly: A Differential Diagnosis and Case Report of Late-Onset Huntington\u2019s Disease in an Octogenarian"],"prefix":"10.1177","volume":"12","author":[{"given":"Alissa S.","family":"Higinbotham","sequence":"first","affiliation":[{"name":"Parkinson\u2019s Disease and Movement Disorders, University of Virginia Health System, Charlottesville, VA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne D.","family":"DeBrosse","sequence":"additional","affiliation":[{"name":"Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"},{"name":"Case Western Reserve University, Cleveland, OH, USA"},{"name":"Center for Human Genetics, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Gunzler","sequence":"additional","affiliation":[{"name":"Neurological Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"},{"name":"Case Western Reserve University, Cleveland, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"4","key":"10.3233\/JHD-230596_ref1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s00415-003-1010-7","article-title":"Cause and course in a series of patients with sporadic chorea","volume":"250","author":"Piccolo","year":"2003","journal-title":"J Neurol"},{"issue":"1","key":"10.3233\/JHD-230596_ref2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.14802\/jmd.20081","article-title":"Generalized chorea due to secondary polycythemia responding to phlebotomy","volume":"14","author":"Cherian","year":"2021","journal-title":"J Mov Disord"},{"issue":"4","key":"10.3233\/JHD-230596_ref3","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/j.cger.2006.06.005","article-title":"Geriatric chorea","volume":"22","author":"Lorincz","year":"2006","journal-title":"Clin Geriatr Med."},{"key":"10.3233\/JHD-230596_ref4","doi-asserted-by":"crossref","first-page":"790514","DOI":"10.3389\/fneur.2021.790514","article-title":"Case Report HSV-2 encephalitis presenting with chorea; effects of infection alone or combination of infection and autoimmunity","volume":"12","author":"Kolesnik","year":"2021","journal-title":"Front Neurol"},{"key":"10.3233\/JHD-230596_ref5","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5334\/tohm.351","article-title":"Treatment of secondary chorea: A review of the current literature","volume":"10","author":"Feinstein","year":"2020","journal-title":"Tremor Other Hyperkinet Mov (N Y)"},{"issue":"3","key":"10.3233\/JHD-230596_ref6","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4103\/0028-3886.53277","article-title":"Chorea as the presenting feature of neurosyphilis","volume":"57","author":"Ozben","year":"2009","journal-title":"Neurol India"},{"issue":"4","key":"10.3233\/JHD-230596_ref7","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1445-5994.1998.tb02075.x","article-title":"The causes of sporadic and \u2018senile\u2019 chorea","volume":"28","author":"Warren","year":"1998","journal-title":"Aust N Z J Med"},{"issue":"18","key":"10.3233\/JHD-230596_ref8","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1212\/WNL.0000000000003887","article-title":"Clinical manifestations of the anti-IgLON5 disease","volume":"88","author":"Gaig","year":"2017","journal-title":"Neurology"},{"key":"10.3233\/JHD-230596_ref9","doi-asserted-by":"crossref","first-page":"829076","DOI":"10.3389\/fneur.2022.829076","article-title":"Autoimmune and paraneoplastic chorea: A review of the literature","volume":"13","author":"Kyle","year":"2022","journal-title":"Front Neurol"},{"issue":"8","key":"10.3233\/JHD-230596_ref10","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1111\/ene.15353","article-title":"Acute onset movement disorders in diabetes mellitus: A clinical series of 59 patients","volume":"29","author":"Dubey","year":"2022","journal-title":"Eur J Neurol"},{"key":"10.3233\/JHD-230596_ref11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.parkreldis.2018.11.009","article-title":"Clinical and genetic characteristics of late-onset Huntington\u2019s disease","volume":"61","author":"Oosterloo","year":"2019","journal-title":"Parkinsonism Relat Disord"},{"key":"10.3233\/JHD-230596_ref12","unstructured":"Genetic Modifiers of Huntington\u2019s Disease (GeM-HD) Consortium. Electronic address: Gusella@helix.mgh.harvard.edu; Genetic Modifiers of Huntington\u2019s Disease (GeM-HD) Consortium. CAG repeat not polyglutamine length determines timing of Huntington\u2019s disease onset. Cell 2019;178(4):887\u2013900.e14."},{"issue":"4","key":"10.3233\/JHD-230596_ref13","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1007\/s13311-019-00768-7","article-title":"DNA damage repair in Huntington\u2019s disease and other neurodegenerative diseases","volume":"16","author":"Maiuri","year":"2019","journal-title":"Neurotherapeutics"},{"issue":"3","key":"10.3233\/JHD-230596_ref14","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3233\/JHD-150169","article-title":"The Genetic Modifiers of Motor OnsetAge (GeM MOA) Website: Genome-wide association analysis for genetic modifiers of Huntington\u2019s disease","volume":"4","author":"Correia","year":"2015","journal-title":"J Huntingtons Dis"},{"issue":"7","key":"10.3233\/JHD-230596_ref15","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S1474-4422(22)00120-X","article-title":"A biological classification of Huntington\u2019s disease: The Integrated Staging System","volume":"21","author":"Tabrizi","year":"2022","journal-title":"Lancet Neurol"}],"container-title":["Journal of Huntington's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JHD-230596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:56:20Z","timestamp":1777452980000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JHD-230596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,15]]},"references-count":15,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3233\/jhd-230596","relation":{},"ISSN":["1879-6397","1879-6400"],"issn-type":[{"value":"1879-6397","type":"print"},{"value":"1879-6400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,15]]}}}