{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T10:54:03Z","timestamp":1787828043042,"version":"build-2784847793"},"reference-count":30,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHD"],"published-print":{"date-parts":[[2024,7,2]]},"abstract":"<jats:p>Background: Huntington\u2019s disease (HD) is a neurodegenerative disease that presents families with significant numbers of stressful events. However, relatively little empirical research has characterized the stressors encountered by members of HD-affected families and their correlations with psychological symptoms. Objective: This study examined frequencies of specific stressors in HD patients and at-risk individuals and the correlates of these stressors with demographics, disease characteristics, and symptoms of depression and anxiety. Methods: HD patients (n\u200a=\u200a57) and at-risk individuals (n\u200a=\u200a81) completed the Responses to Stress Questionnaire \u2013Huntington\u2019s Disease Version to assess HD-related stressors. Participants completed measures of depression and anxiety symptoms. Patient health records were accessed to obtain information related to disease characteristics. Results: Patients endorsed a mean number of 5.05 stressors (SD\u200a=\u200a2.74) out of the 10-item list. Demographics were not related to total stressors, but disease characteristics were significantly related to specific stressors. At-risk individuals endorsed a mean number of 3.20 stressors (SD\u200a=\u200a2.65) out of the 11-item list. Age and sex were significantly related to specific stressors. Total number of stressors was significantly related to depression (\u03b2=0.67, p\u200a&lt;\u200a0.001) and anxiety symptoms (\u03b2=0.58, p\u200a&lt;\u200a0.001) in patients and at-risk individuals (\u03b2=0.35, p\u200a=\u200a0.003 and \u03b2=0.32, p\u200a=\u200a0.006, respectively). Conclusions: hese findings emphasize the significant burden of stress experienced by HD patients and at-risk individuals. We highlight a need for more specific stress-based measures and psychosocial support interventions for HD-affected families.<\/jats:p>","DOI":"10.3233\/jhd-231515","type":"journal-article","created":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T11:48:44Z","timestamp":1712317724000},"page":"215-224","source":"Crossref","is-referenced-by-count":4,"title":["Stress in Huntington\u2019s Disease: Characteristics and Correlates in Patients and At-Risk Individuals"],"prefix":"10.1177","volume":"13","author":[{"given":"Abigail L.B.","family":"Snow","sequence":"first","affiliation":[{"name":"Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, USA"},{"name":"Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abagail E.","family":"Ciriegio","sequence":"additional","affiliation":[{"name":"Department of Psychology and Human Development, Vanderbilt University, 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