{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T06:03:12Z","timestamp":1792735392455,"version":"4.5.0"},"reference-count":24,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHD"],"published-print":{"date-parts":[[2024,9,10]]},"abstract":"<jats:p>Background: Anosognosia, or unawareness of symptoms, is common in Huntington\u2019s disease (HD), but the neuroanatomical basis of this is unknown. Objective: To identify neuroanatomical correlates of HD anosognosia using structural MRI data. Methods: We leveraged a pre-processed dataset of 570 HD participants across the well-characterized PREDICT-HD and TRACK-HD cohort studies. Anosognosia index was operationalized as the score discrepancies between HD participants and their caregivers on the Frontal Systems Behavior Scale (FrSBe). Results: Univariate correlation analyses identified volumes of globus pallidus, putamen, caudate, basal forebrain, substantia nigra, angular gyrus, and cingulate cortex as significant correlates of anosognosia after correction for multiple comparisons. A multivariable model constructed with stepwise regression that included volumetric data showed globus pallidus volume alone explained more variance in anosognosia severity than motor impairment or CAP score alone. Conclusions: Anosognosia appears to be related to degeneration affecting both cortical and subcortical areas. Globus pallidus neurodegeneration in particular appears to be a key process of importance.<\/jats:p>","DOI":"10.3233\/jhd-240010","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T10:43:36Z","timestamp":1725965016000},"page":"315-320","source":"Crossref","is-referenced-by-count":2,"title":["Structural MRI Correlates of Anosognosia in Huntington\u2019s Disease"],"prefix":"10.1177","volume":"13","author":[{"given":"Jared T.","family":"Hinkle","sequence":"first","affiliation":[{"name":"Department of Psychiatry JHUSOM, Baltimore MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Wildermuth","sequence":"additional","affiliation":[{"name":"Medical Scientist Training Program, University of Maryland School of Medicine, Baltimore, MD, USA"},{"name":"Institute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao 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