{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:27:58Z","timestamp":1780500478163,"version":"3.54.1"},"reference-count":21,"publisher":"SAGE Publications","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHD"],"published-print":{"date-parts":[[2024,9,10]]},"abstract":"<jats:p>Speech alterations have been reported in manifest Huntington\u2019s disease (HD) and premanifest mutation carriers (preHD). The aim of our study was to explore these alterations in preHD and whether they can be used as biomarkers. 13 preHD mutation carriers performed reading task, sustained phonation task and syllable repetition tasks at baseline and after 21 months, as well as clinical examination and MRI. Syllable repetition capacity and self-chosen velocity of single syllable repetition differed significantly between time points. There were no changes in clinical ratings or MRI volumetry. Measurements of speech might be sensitive tools for monitoring subclinical changes in preHD.<\/jats:p>","DOI":"10.3233\/jhd-240021","type":"journal-article","created":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T10:50:27Z","timestamp":1720781427000},"page":"369-373","source":"Crossref","is-referenced-by-count":8,"title":["Speech Biomarkers in Huntington\u2019s Disease: A Longitudinal Follow-Up Study in Premanifest Mutation Carriers"],"prefix":"10.1177","volume":"13","author":[{"given":"Carsten","family":"Saft","sequence":"first","affiliation":[{"name":"Department of Neurology, Huntington-Centre NRW, St. Josef Hospital, Ruhr-University of Bochum, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Jessen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Huntington-Centre NRW, St. Josef Hospital, Ruhr-University of Bochum, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Department of Neurology, Huntington-Centre NRW, St. Josef Hospital, Ruhr-University of Bochum, Bochum, Germany"},{"name":"Department of Neuropsychiatry, Huntington Centre South, kbo-Isar-Amper-Klinikum, Taufkirchen (Vils), Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten","family":"Lukas","sequence":"additional","affiliation":[{"name":"Institute of Neuroradiology, St. Josef Hospital, Ruhr-University of Bochum, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Skodda","sequence":"additional","affiliation":[{"name":"Department of Neurology, Knappschaftskrankenhaus, Ruhr-University of Bochum, Bochum, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JHD-240021_ref1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0093-934X(87)90124-6","article-title":"Speech timing in Parkinson\u2019s and Huntington\u2019s disease","volume":"32","author":"Ludlow","year":"1987","journal-title":"Brain and Language"},{"key":"10.3233\/JHD-240021_ref2","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s00702-013-1115-9","article-title":"Impaired motor speech performance in Huntington\u2019s disease","volume":"121","author":"Skodda","year":"2014","journal-title":"J Neural Transm"},{"key":"10.3233\/JHD-240021_ref3","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1212\/WNL.0000000000002550","article-title":"Two different phenomena in basic motor speech performance in premanifest Huntington disease","volume":"86","author":"Skodda","year":"2016","journal-title":"Neurology"},{"key":"10.3233\/JHD-240021_ref4","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1037\/a0018905","article-title":"Self-paced timing detects and tracks change in prodromal Huntington disease","volume":"24","author":"Rowe","year":"2010","journal-title":"Neuropsychology"},{"key":"10.3233\/JHD-240021_ref5","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1186\/1750-1172-5-40","article-title":"Huntington\u2019s disease: A clinical review","volume":"5","author":"Roos","year":"2010","journal-title":"Orphanet JRare Dis"},{"key":"10.3233\/JHD-240021_ref6","doi-asserted-by":"crossref","first-page":"3273","DOI":"10.1016\/j.neuropsychologia.2012.09.011","article-title":"Speech acoustic markers of early stage and prodromal Huntington\u2019s disease: A marker of disease onset?","volume":"50","author":"Vogel","year":"2012","journal-title":"Neuropsychologia"},{"key":"10.3233\/JHD-240021_ref7","doi-asserted-by":"crossref","first-page":"e113412","DOI":"10.1371\/journal.pone.0113412","article-title":"Phonatory dysfunction as apreclinical symptom of Huntington disease","volume":"9","author":"Rusz","year":"2014","journal-title":"PloS One"},{"key":"10.3233\/JHD-240021_ref8","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1111\/ene.15726","article-title":"Speech biomarkers in Huntington\u2019s disease: A cross-sectional study in pre-symptomatic, prodromal and early manifest stages","volume":"30","author":"Kouba","year":"2023","journal-title":"Eur J Neurol"},{"key":"10.3233\/JHD-240021_ref9","doi-asserted-by":"crossref","first-page":"22787","DOI":"10.1038\/s41598-023-49352-2","article-title":"Towards interpretable speech biomarkers: Exploring MFCCs","volume":"13","author":"Tracey","year":"2023","journal-title":"Sci Rep"},{"key":"10.3233\/JHD-240021_ref10","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1212\/WNL.0b013e3182020123","article-title":"Tapping linked to function and structure in premanifest and symptomatic Huntington disease","volume":"75","author":"Bechtel","year":"2010","journal-title":"Neurology"},{"key":"10.3233\/JHD-240021_ref11","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1016\/S1474-4422(09)70170-X","article-title":"Biological and clinical manifestations of Huntington\u2019s disease in the longitudinal TRACK-HD study: Cross-sectional analysis of baseline data","volume":"8","author":"Tabrizi","year":"2009","journal-title":"Lancet Neurol"},{"key":"10.3233\/JHD-240021_ref12","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/S1474-4422(20)30143-5","article-title":"Biological and clinical characteristics of gene carriers far from predicted onset in the Huntington\u2019s disease Young Adult Study (HD-YAS): A cross-sectional analysis","volume":"19","author":"Scahill","year":"2020","journal-title":"Lancet Neurol"},{"key":"10.3233\/JHD-240021_ref13","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S1474-4422(22)00120-X","article-title":"A biological classification of Huntington\u2019s disease: The Integrated Staging System (HD-ISS)","volume":"21","author":"Tabrizi","year":"2022","journal-title":"Lancet Neurol"},{"key":"10.3233\/JHD-240021_ref14","first-page":"136","article-title":"Huntington Study Group","volume":"11","author":"Unified Huntington\u2019s Disease Rating Scale: Reliability and consistency","year":"1996","journal-title":"Mov Disord"},{"key":"10.3233\/JHD-240021_ref15","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1007\/s00415-003-0256-4","article-title":"Assessment of complex movements reflects dysfunction in Huntington\u2019s disease","volume":"250","author":"Saft","year":"2003","journal-title":"J Neurol"},{"key":"10.3233\/JHD-240021_ref16","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1002\/mds.20939","article-title":"Assessment of simple movements reflects impairment in Huntington\u2019s disease","volume":"21","author":"Saft","year":"2006","journal-title":"Mov Disord"},{"key":"10.3233\/JHD-240021_ref17","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/ana.410410521","article-title":"CAG repeat number governs the development rate of pathology in Huntington\u2019s disease","volume":"41","author":"Penney","year":"1997","journal-title":"Ann Neurol"},{"key":"10.3233\/JHD-240021_ref18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1399-0004.2004.00241.x","article-title":"A new model for prediction of the age of onset and penetrance for Huntington\u2019s disease based on CAG length","volume":"65","author":"Langbehn","year":"2004","journal-title":"Clin Genet"},{"key":"10.3233\/JHD-240021_ref19","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1212\/01.WNL.0000132965.14653.D1","article-title":"Onset and rate of striatal atrophy in preclinical Huntington disease","volume":"63","author":"Aylward","year":"2004","journal-title":"Neurology"},{"key":"10.3233\/JHD-240021_ref20","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/S1053-8119(03)00304-5","article-title":"Neural correlates of the complexity of rhythmic finger tapping","volume":"20","author":"Dhamala","year":"2003","journal-title":"Neuroimage"},{"key":"10.3233\/JHD-240021_ref21","doi-asserted-by":"crossref","first-page":"e1263","DOI":"10.1371\/journal.pone.0001263","article-title":"Time processing in Huntington\u2019sdisease: A group-control study","volume":"2","author":"Beste","year":"2007","journal-title":"PloS One"}],"container-title":["Journal of Huntington's Disease"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JHD-240021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:56:27Z","timestamp":1777452987000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JHD-240021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,10]]},"references-count":21,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3233\/jhd-240021","relation":{},"ISSN":["1879-6397","1879-6400"],"issn-type":[{"value":"1879-6397","type":"print"},{"value":"1879-6400","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,10]]}}}