{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T19:42:09Z","timestamp":1790797329116,"version":"4.1.0"},"reference-count":97,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JHD"],"published-print":{"date-parts":[[2024,9,10]]},"abstract":"<jats:p>Structural magnetic resonance imaging (MRI) is a powerful tool to visualize 3D neuroanatomy and assess pathology and disease progression in neurodegenerative disorders such as Huntington\u2019s disease (HD). The development of mouse models of HD that reproduce many of the psychiatric, motor and cognitive impairments observed in human HD has improved our understanding of the disease and provided opportunities for testing novel therapies. Similar to the clinical scenario, MRI of mouse models of HD demonstrates onset and progression of brain pathology. Here, we provided an overview of the articles that used structural MRI in mouse models of HD to date, highlighting the differences between studies and models and describing gaps in the current state of knowledge and recommendations for future studies.<\/jats:p>","DOI":"10.3233\/jhd-240045","type":"journal-article","created":{"date-parts":[[2024,8,27]],"date-time":"2024-08-27T10:09:34Z","timestamp":1724753374000},"page":"279-299","source":"Crossref","is-referenced-by-count":5,"title":["Magnetic Resonance Imaging to Detect Structural Brain Changes in Huntington\u2019s Disease: A Review of Data from Mouse Models"],"prefix":"10.1177","volume":"13","author":[{"given":"Jenna","family":"Hanrahan","sequence":"first","affiliation":[{"name":"Department of Chemistry, Memorial University of Newfoundland, St. John\u2019s, Newfoundland and Labrador, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drew P.","family":"Locke","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Memorial University of Newfoundland, St. John\u2019s, Newfoundland and Labrador, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay S.","family":"Cahill","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Memorial University of Newfoundland, St. John\u2019s, Newfoundland and Labrador, Canada"},{"name":"Discipline of Radiology, Memorial University of Newfoundland, St. John\u2019s, Newfoundland and Labrador, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","reference":[{"key":"10.3233\/JHD-240045_ref1","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/B978-0-323-85654-6.00042-3","volume-title":"Neurobiology of Brain Disorders","author":"Parsons","year":"2023"},{"key":"10.3233\/JHD-240045_ref2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ajhg.2021.12.002","article-title":"Longer CAG 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