{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:58:05Z","timestamp":1789617485551,"version":"build-2803163510"},"reference-count":21,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2015,9,21]],"date-time":"2015-09-21T00:00:00Z","timestamp":1442793600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuromuscular Diseases"],"published-print":{"date-parts":[[2015,9,21]]},"abstract":"\n Background:<\/jats:title>\n The rate of symptom progression during pregnancy in myotonic dystrophy (DM) is not currently known. Further, there is little data regarding the rate of pregnancy complications and neonatal outcomes in DM.<\/jats:p>\n <\/jats:sec>\n \n Objective:<\/jats:title>\n This study assesses symptom progression and complication rates during pregnancy in women with DM.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n DM women completed surveys regarding their prior pregnancies. Participants identified complications during their pregnancies and completed the Myotonic Dystrophy Health Index-Short Form (MDHI-SF) to measure their disease burden and identify the severity of select symptoms six-months prior to, during, and six-months after their first pregnancy.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n 152 women with DM reported on 375 pregnancies. Among these pregnancies, there was a 32.5% miscarriage rate. Some complications were common including: pre-term labor (27.8%), pre-eclampsia (10.4%), and peripartum hemorrhage (13.9%). Participants\u2019 perception of their mobility and ability to perform activities, as measured by the MDHI-SF, worsened during pregnancy and did not recover during the post-partum period.<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n Miscarriage, maternal disease progression during pregnancy, and other pregnancy related complications may occur in DM. Women with DM should be counseled on these potential risks prior to considering pregnancy.<\/jats:p>\n <\/jats:sec>","DOI":"10.3233\/jnd-150095","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T08:37:44Z","timestamp":1448613464000},"page":"447-452","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["The Impact of Pregnancy on Myotonic Dystrophy: A Registry-Based Study"],"prefix":"10.1177","volume":"2","author":[{"given":"Nicholas E.","family":"Johnson","sequence":"first","affiliation":[{"name":"Department of Neurology, The University of Utah, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, The University of Utah, UT, USA"},{"name":"Division of Epidemiology, The University of Utah, UT, USA"},{"name":"Division of Public Health, The University of Utah, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eriko","family":"Nasser","sequence":"additional","affiliation":[{"name":"The Myotonic Dystrophy Foundation, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharine A.","family":"Hagerman","sequence":"additional","affiliation":[{"name":"The Department of Neurology, Stanford University, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, The University of Utah, UT, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Ciafaloni","sequence":"additional","affiliation":[{"name":"The Department of Neurology, University of Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad R.","family":"Heatwole","sequence":"additional","affiliation":[{"name":"The Department of Neurology, University of Rochester, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,10,7]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1546326"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1546325"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90154-5"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1086\/378566"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1062125"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1038\/570"},{"key":"e_1_3_2_8_2","unstructured":"Harper P 2001 Myotonic Dystrophy 3rd ed London W.B. Saunders"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0032-1329202"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24097"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2014.07.004"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2012.02.020"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000198227.91131.1e"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e318260cbe6"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/uog.3859"},{"key":"e_1_3_2_16_2","unstructured":"Ventura SJ Curtin SC Abma JC Henshaw SK 2012 Estimated pregnancy rates and rates of pregnancy outcomes for the United States -National vital statistics reports: From the centers for disease control and prevention National Center for Health Statistics National Vital Statistics System 60 7 1 21"},{"key":"e_1_3_2_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6564"},{"issue":"4","key":"e_1_3_2_18_2","first-page":"351","article-title":"Trends in postpartum hemorrhage: United States, -American Journal of Obstetrics and Gynecology","volume":"202","author":"Callaghan WM","year":"2010","unstructured":"Callaghan WM, Kuklina EV, Berg CJ 2010 Trends in postpartum hemorrhage: United States, -American Journal of Obstetrics and Gynecology 353 e 202 4 351 356","journal-title":"353 e"},{"key":"e_1_3_2_19_2","unstructured":"Centers for Disease Control and Prevention American Society for Reproductive Medicine Society for Assisted Reproductive Technology. 2011 Assisted Reproductive Technology Fertility Clinic Success Rates Report. 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