{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:46:24Z","timestamp":1792655184565,"version":"4.5.0"},"reference-count":82,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuromuscular Diseases"],"published-print":{"date-parts":[[2016,11,29]]},"abstract":"<jats:p>During the complex series of events leading to muscle contraction, the initial electric signal coming from motor neurons is transformed into an increase in calcium concentration that triggers sliding of myofibrils. This process, referred to as excitation\u2013contraction coupling, is reliant upon the calcium-release complex, which is restricted spatially to a\u00a0sub-compartment of muscle cells (\u201cthe triad\u201d) and regulated precisely. Any dysfunction in the calcium-release complex leads to muscle impairment and myopathy. Various causes can lead to alterations in excitation\u2013contraction coupling and to muscle diseases. The latter are reviewed and classified into four categories: (i) mutation in a\u00a0protein of the calcium-release complex; (ii) alteration in triad structure; (iii) modification of regulation of channels; (iv) modification in calcium stores within the muscle. Current knowledge of the pathophysiologic mechanisms in each category is described and discussed.<\/jats:p>","DOI":"10.3233\/jnd-160172","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T10:52:53Z","timestamp":1477392773000},"page":"443-453","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Excitation-Contraction Coupling Alterations in Myopathies"],"prefix":"10.1177","volume":"3","author":[{"given":"Isabelle","family":"Marty","sequence":"first","affiliation":[{"name":"University Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France"},{"name":"INSERM, U1216, F-38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Faur\u00e9","sequence":"additional","affiliation":[{"name":"University Grenoble Alpes, Grenoble Institut des Neurosciences, GIN, F-38000 Grenoble, France"},{"name":"INSERM, U1216, F-38000 Grenoble, France"},{"name":"CHU de Grenoble, F-38000 Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,10,24]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1007\/BF00712033"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1038\/nature13916"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1038\/nature14063"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1038\/nature13950"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1002\/humu.21278"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22119"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/79.4.610"},{"key":"ref008","first-page":"70","volume":"24","author":"Romero NB","year":"2005","journal-title":"Acta Myol"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.7.4164"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.22.2581"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1689"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10231"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg121"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awg244"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1086\/342719"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20231"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200503000-00007"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep204"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew047"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-010-0794-4"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a003996"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.11.009"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.42.26332"},{"key":"ref024","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.2.693"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.104.048447"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2008.10.001"},{"key":"ref027","doi-asserted-by":"publisher","DOI":"10.1016\/S1050-1738(02)00163-9"},{"key":"ref028","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.071048198"},{"key":"ref029","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201010523"},{"key":"ref030","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2010.09.009"},{"key":"ref031","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20696"},{"key":"ref032","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl221"},{"key":"ref033","doi-asserted-by":"publisher","DOI":"10.3233\/JND-150073"},{"key":"ref034","doi-asserted-by":"publisher","DOI":"10.1086\/515454"},{"key":"ref035","first-page":"301","volume":"6","author":"Moreau A","year":"2015","journal-title":"5 that are associated with arrhythmias and dilated cardiomyopathy generate gating pore currents. Front Pharmacol"},{"key":"ref036","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00008.2010"},{"key":"ref037","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(02)75396-4"},{"key":"ref038","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.110.226845"},{"key":"ref039","doi-asserted-by":"publisher","DOI":"10.1186\/s13395-015-0035-9"},{"key":"ref040","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22631"},{"key":"ref041","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.686261"},{"key":"ref042","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M705702200"},{"key":"ref043","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0902919106"},{"key":"ref044","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.022442"},{"issue":"14","key":"ref045","first-page":"3443","volume":"125","author":"Fourest-Lieuvin A","year":"2012","journal-title":"J\u00a0Cell Sci"},{"key":"ref046","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(03)00406-6"},{"key":"ref047","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds104"},{"key":"ref048","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.015397"},{"key":"ref049","doi-asserted-by":"publisher","DOI":"10.1111\/pace.12813"},{"key":"ref050","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196907242810403"},{"key":"ref051","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.91"},{"key":"ref052","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1310571110"},{"key":"ref053","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2952"},{"key":"ref054","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1423113112"},{"key":"ref055","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12938"},{"key":"ref056","doi-asserted-by":"publisher","DOI":"10.1186\/2044-5040-1-16"},{"key":"ref057","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201012157"},{"key":"ref058","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.007"},{"key":"ref059","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900082"},{"key":"ref060","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2014-102623"},{"key":"ref061","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1312520111"},{"key":"ref062","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu477"},{"key":"ref063","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00054-4"},{"key":"ref064","doi-asserted-by":"publisher","DOI":"10.1080\/15216540500092328"},{"key":"ref065","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600876200"},{"key":"ref066","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1569"},{"key":"ref067","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90214-3"},{"key":"ref068","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2005.7.870"},{"key":"ref069","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607590200"},{"key":"ref070","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1916"},{"key":"ref071","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.05.014"},{"key":"ref072","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.02.042"},{"key":"ref073","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21644"},{"key":"ref074","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu602"},{"key":"ref075","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws036"},{"key":"ref076","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12076"},{"key":"ref077","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2374"},{"key":"ref078","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900705106"},{"key":"ref079","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000372"},{"key":"ref080","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu272"},{"key":"ref081","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2014.00339"},{"key":"ref082","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a6ca62"}],"container-title":["Journal of Neuromuscular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JND-160172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JND-160172","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JND-160172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:53:18Z","timestamp":1777506798000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JND-160172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,24]]},"references-count":82,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,11,29]]}},"alternative-id":["10.3233\/JND-160172"],"URL":"https:\/\/doi.org\/10.3233\/jnd-160172","relation":{},"ISSN":["2214-3599","2214-3602"],"issn-type":[{"value":"2214-3599","type":"print"},{"value":"2214-3602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,24]]}}}