{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:13:54Z","timestamp":1777857234640,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2016,10,24]],"date-time":"2016-10-24T00:00:00Z","timestamp":1477267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuromuscular Diseases"],"published-print":{"date-parts":[[2016,11,29]]},"abstract":"<jats:p>Spinal muscular atrophy (SMA) is an early-onset motor neuron disease that leads to loss of muscle function. Butyrate (BA)-based compounds markedly improve the survival and motor phenotype of SMA mice. In this study, we examine the protective effects of the BA prodrug pivaloyloxymethyl butyrate (AN9) on the survival of SMN \u03947 SMA mice. Oral administration of AN9 beginning at PND04 almost doubled the average lifespan of SMN \u03947 SMA mice. AN9 treatment also increased the growth rate of SMN \u03947 SMA mice when compared to vehicle-treated SMN \u03947 SMA mice. In conclusion, BA prodrugs like AN9 have ameliorative effects on SMN \u03947 SMA mice.<\/jats:p>","DOI":"10.3233\/jnd-160187","type":"journal-article","created":{"date-parts":[[2016,10,25]],"date-time":"2016-10-25T10:52:39Z","timestamp":1477392759000},"page":"511-515","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Effect of the Butyrate Prodrug Pivaloyloxymethyl Butyrate (AN9) on a Mouse Model for Spinal Muscular Atrophy"],"prefix":"10.1177","volume":"3","author":[{"given":"Jonathan D.","family":"Edwards","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew E. R.","family":"Butchbach","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry and Pharmacology, The Ohio State University Wexner Medical Center, Columbus, OH, USA"},{"name":"Center for Applied Clinical Genomics, Nemours Biomedical Research, Nemours Alfred I. duPont Hospital for Children, Wilmington, DE, USA"},{"name":"Center for Pediatric Research, Nemours Biomedical Research, Nemours Alfred I. duPont Hospital for Children, Wilmington, DE, USA"},{"name":"Department of Pediatrics, Thomas Jefferson University, Philadelphia, PA, USA"},{"name":"Department of Biological Sciences, University of Delaware, Newark, DE, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,10,24]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1006\/nbdi.1996.0010"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.15.6.409"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-0528.2002.02083.x"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90460-3"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2670"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.171105098"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2016.02.009"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1007\/s002800050922"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1021\/jm00082a009"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1007\/BF01208637"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0567"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1215\/15228517-2006-032"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-008-9179-x"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi078"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2009.11.148"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21449"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.03.005"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2006.11.002"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.04.009"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201102"},{"key":"ref021","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)34804-4"},{"key":"ref022","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.5.2239"},{"key":"ref023","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(78)90305-7"},{"key":"ref024","first-page":"4334","volume":"6","author":"Davis T","year":"2000","journal-title":"Clin Cancer Res"},{"key":"ref025","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910560625"},{"key":"ref026","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00670"}],"container-title":["Journal of Neuromuscular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JND-160187","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JND-160187","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JND-160187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:53:19Z","timestamp":1777506799000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JND-160187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,24]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,11,29]]}},"alternative-id":["10.3233\/JND-160187"],"URL":"https:\/\/doi.org\/10.3233\/jnd-160187","relation":{},"ISSN":["2214-3599","2214-3602"],"issn-type":[{"value":"2214-3599","type":"print"},{"value":"2214-3602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,24]]}}}