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For each function, different items were considered and classified according to clinical severity (as indicated by international guidelines) and an incremental scoring was assigned. In addition, a global score incorporating all functions was defined. The scoring system confirmed that despite the significant protective role of steroids, all functions deteriorated with age. The severity of the global score became significantly higher since the age of 13 years. The severity of cardiac, respiratory and nutritional dysfunction was higher since 18 years. Deceased patients were characterized by significantly worse cardiac function, absence of steroid therapy and later use of respiratory assistive devices. The index proposed in this pilot study is a promising tool able to aggregate and correlate heterogeneous functions. It could become either an individual prognostic indicator of decline or a global score to evaluate changes in clinical trials therefore allowing multicenter studies, optimizing the management of both the primary and the secondary complications of the disease and understanding their relative impact.<\/jats:p>","DOI":"10.3233\/jnd-190417","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T15:02:46Z","timestamp":1608649366000},"page":"235-249","source":"Crossref","is-referenced-by-count":2,"title":["A Multidisciplinary Evaluation of Patients with DMD in An Italian Tertiary Care Center"],"prefix":"10.1177","volume":"8","author":[{"given":"A.","family":"LoMauro","sequence":"first","affiliation":[{"name":"Dipartimento di Elettronica, Informazione e Bioingegneria, Politecnico di Milano, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Gandossini","sequence":"additional","affiliation":[{"name":"Scientific Institute IRCCS E. 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