{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T01:09:59Z","timestamp":1777856999663,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JND"],"published-print":{"date-parts":[[2021,3,2]]},"abstract":"<jats:p>The prognostic value of cerebrospinal fluid (CSF) protein in Guillain Barr\u00e9 Syndrome (GBS) is unclear. We aimed to explore the potential association between CSF protein level and mechanical ventilation in GBS. We undertook a retrospective study of GBS patients from January 2000 to November 2019 at the University of Michigan. 94 patients were ultimately included for evaluation. After adjusting for the Erasmus GBS Respiratory Insufficiency Scale (EGRIS), we did not find a significant difference in CSF protein between ventilated and non-ventilated patients. Elevated CSF protein level does not appear to portend an increased likelihood of mechanical ventilation in GBS patients.<\/jats:p>","DOI":"10.3233\/jnd-200581","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T12:25:09Z","timestamp":1610713509000},"page":"299-303","source":"Crossref","is-referenced-by-count":6,"title":["Cerebrospinal Fluid Protein Level and Mechanical Ventilation in Guillain-Barr\u00e9 Syndrome patients"],"prefix":"10.1177","volume":"8","author":[{"given":"Long","family":"Davalos","sequence":"first","affiliation":[{"name":"University of Michigan School of Medicine, Department of Neurology, Division of Neuromuscular Medicine, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dustin","family":"Nowacek","sequence":"additional","affiliation":[{"name":"University of Michigan School of Medicine, Department of Neurology, Division of Neuromuscular Medicine, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bakri","family":"Elsheikh","sequence":"additional","affiliation":[{"name":"Ohio State University Wexner Medical Center, Department of Neurology, Division of Neuromuscular Medicine, Columbus, OH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evan L.","family":"Reynolds","sequence":"additional","affiliation":[{"name":"University of Michigan School of Medicine, Department of Neurology, Division of Neuromuscular Medicine, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amro","family":"Maher Stino","sequence":"additional","affiliation":[{"name":"University of Michigan School of Medicine, Department of Neurology, Division of Neuromuscular Medicine, Ann Arbor, MI, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","reference":[{"issue":"6","key":"10.3233\/JND-200581_ref1","doi-asserted-by":"crossref","first-page":"e193","DOI":"10.1016\/j.lpm.2013.02.328","article-title":"Diagnosis, treatment and prognosis of Guillain-Barr\u00e9 syndrome (GBS)","volume":"42","author":"van Doorn","year":"2013","journal-title":"La Presse M\u00e9dicale"},{"issue":"1","key":"10.3233\/JND-200581_ref2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1212\/WNL.50.1.11","article-title":"Respiratory management in acute neurologic illness","volume":"50","author":"Wijdicks","year":"1998","journal-title":"Neurology"},{"issue":"2","key":"10.3233\/JND-200581_ref3","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1001\/jamaneurol.2016.4480","article-title":"Association of albumin levels with outcome in intravenous immunoglobulin\u2013treated guillain-barr\u00e9 syndrome","volume":"74","author":"Fokkink","year":"2017","journal-title":"Jama Neurology"},{"issue":"1","key":"10.3233\/JND-200581_ref4","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/00003246-200301000-00044","article-title":"French Cooperative Group on Plasma Exchange in Guillain-Barr\u00e9 Syndrome. Early predictors of mechanical ventilation in Guillain-Barr\u00e9 syndrome","volume":"31","author":"Sharshar","year":"2003","journal-title":"Crit Care Med"},{"issue":"6","key":"10.3233\/JND-200581_ref5","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1002\/ana.21976","article-title":"Prediction of respiratory insufficiency in Guillain-Barr\u00e9 syndrome","volume":"67","author":"Walgaard","year":"2010","journal-title":"Annals of Neurology"},{"issue":"6","key":"10.3233\/JND-200581_ref6","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1001\/archneur.58.6.893","article-title":"Anticipating mechanical ventilation in Guillain-Barr\u00e9 syndrome","volume":"58","author":"Lawn","year":"2001","journal-title":"Archives of Neurology"},{"issue":"1","key":"10.3233\/JND-200581_ref7","doi-asserted-by":"crossref","first-page":"R65","DOI":"10.1186\/cc10043","article-title":"A simple functional marker to predict the need for prolonged mechanical ventilation in patients with Guillain-Barr\u00e9 syndrome","volume":"15","author":"Fourrier","year":"2011","journal-title":"Critical Care.R"},{"issue":"1","key":"10.3233\/JND-200581_ref8","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/s13054-015-1037-z","article-title":"Predictors for mechanical ventilation and short-term prognosis in patients with Guillain-Barr\u00e9 syndrome","volume":"19","author":"Wu","year":"2015","journal-title":"Critical Care"},{"issue":"6","key":"10.3233\/JND-200581_ref9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1038\/nri2550","article-title":"Autoimmune T cell responses in the central nervous system","volume":"9","author":"Goverman","year":"2009","journal-title":"Nature Reviews Immunology"},{"issue":"Pt 1","key":"10.3233\/JND-200581_ref10","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/brain\/awt285","article-title":"Diagnosis of Guillain-Barr\u00e9 syndrome and validation of Brighton criteria","volume":"137","author":"Fokke","year":"2014","journal-title":"Brain"},{"issue":"1","key":"10.3233\/JND-200581_ref11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/jns.12104","article-title":"Cytoalbuminologic dissociation in Asian patients with Guillain-Barr\u00e9 and Miller Fisher syndromes","volume":"20","author":"Wong","year":"2015","journal-title":"J Peripher Nerv Syst"},{"issue":"1-2","key":"10.3233\/JND-200581_ref12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jns.2014.02.019","article-title":"Increased cerebrospinal fluid protein and motor conduction studies as prognostic markers of outcome and nerve ultrasound changes in Guillain\u2013Barr\u00e9 syndrome","volume":"340","author":"Kerasnoudis","year":"2014","journal-title":"Journal of the Neurological Sciences"},{"issue":"2","key":"10.3233\/JND-200581_ref13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/CND.0000000000000259","article-title":"CSF Protein Level and Short-Term Prognosis in Guillain\u2013Barr\u00e9 Syndrome","volume":"21","author":"Saba","year":"2019","journal-title":"Journal of Clinical Neuromuscular Disease"},{"issue":"1","key":"10.3233\/JND-200581_ref14","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1002\/mus.21239","article-title":"CSF protein biomarkers for proximal axonal damage improve prognostic accuracy in the acute phase of Guillain-Barr\u00e9 syndrome","volume":"40","author":"Petzold","year":"2009","journal-title":"Muscle & Nerve"},{"issue":"1","key":"10.3233\/JND-200581_ref15","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/mus.23752","article-title":"Serial cerebrospinal fluid neurofilament heavy chain levels in severe Guillain-Barr\u00e9 syndrome","volume":"48","author":"Dujmovic","year":"2013","journal-title":"Muscle & Nerve"},{"key":"10.3233\/JND-200581_ref16","doi-asserted-by":"crossref","unstructured":"Sahin S , Cinar N , Karsidag S . Are cerebrospinal fluid protein levels and plasma neutrophil\/lymphocyte ratio associated with prognosis of Guillain Barr\u00e9 syndrome? Neurology International. 2017;9(2).","DOI":"10.4081\/ni.2017.7032"},{"issue":"10","key":"10.3233\/JND-200581_ref17","first-page":"777","article-title":"Prognostic factors in Guillain-Barre\u2019 syndrome","volume":"42","author":"Singh","year":"1994","journal-title":"J Assoc Physicians India"},{"issue":"2","key":"10.3233\/JND-200581_ref18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1111\/jns.12209","article-title":"International Guillain-Barr\u00e9 Syndrome Outcome Study: Protocol of a prospective observational cohort study on clinical and biological predictors of disease course and outcome in Guillain-Barr\u00e9 syndrome","volume":"22","author":"Jacobs","year":"2017","journal-title":"Journal of the Peripheral Nervous System"}],"container-title":["Journal of Neuromuscular Diseases"],"original-title":[],"link":[{"URL":"https:\/\/content.iospress.com\/download?id=10.3233\/JND-200581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:49:36Z","timestamp":1777506576000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/full\/10.3233\/JND-200581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,2]]},"references-count":18,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3233\/jnd-200581","relation":{},"ISSN":["2214-3599","2214-3602"],"issn-type":[{"value":"2214-3599","type":"print"},{"value":"2214-3602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,2]]}}}