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Domains R1-3 are important for muscle force generation and for association with the sarcolemma, but the nature of this interaction is not fully understood. We measured lipid-binding affinity of 3 peptides containing different spectrin-like repeat modules (R1-3; R1-2; and R1, 2, 22). Lipid-binding affinity was highest with R1-3, suggesting that the complete R1-R3 region could be beneficial and should be considered for inclusion in micro-dystrophin constructs.<\/jats:p>","DOI":"10.3233\/jnd-200622","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T13:40:00Z","timestamp":1616506800000},"page":"489-494","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":6,"title":["Evaluation of the Lipid-binding Properties of Recombinant Dystrophin Spectrin-like Repeat Domains R1-3"],"prefix":"10.1177","volume":"8","author":[{"given":"Grace","family":"Cooper-Olson","sequence":"first","affiliation":[{"name":"Sarepta Therapeutics, Inc., Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise R.","family":"Rodino-Klapac","sequence":"additional","affiliation":[{"name":"Sarepta Therapeutics, Inc., Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachael A.","family":"Potter","sequence":"additional","affiliation":[{"name":"Sarepta Therapeutics, Inc., Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2021,3,23]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90579-4"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(87)90504-6"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c140048"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23810"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002891"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30025-5"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30026-7"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2012.04.078"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2018.07.011"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1038\/343180a0"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.8.1245"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1038\/nm0302-253"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt342"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw210"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.150.6.1399"},{"key":"ref016","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.01.002"},{"key":"ref017","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy113"},{"key":"ref018","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2007.12.014"},{"key":"ref019","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.04.025"},{"key":"ref020","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.D500034-JLR200"}],"container-title":["Journal of Neuromuscular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JND-200622","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JND-200622","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JND-200622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:49:41Z","timestamp":1777506581000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JND-200622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,23]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7,30]]}},"alternative-id":["10.3233\/JND-200622"],"URL":"https:\/\/doi.org\/10.3233\/jnd-200622","relation":{},"ISSN":["2214-3599","2214-3602"],"issn-type":[{"value":"2214-3599","type":"print"},{"value":"2214-3602","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,23]]}}}