{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:29:13Z","timestamp":1788024553599,"version":"build-2784847793"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T00:00:00Z","timestamp":1700092800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuromuscular Diseases"],"published-print":{"date-parts":[[2024,1,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>The CHOP-INTEND is an established outcome measure used to assess motor function in young and weak SMA patients previously validated in type I infants older than 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The aim of our study was to assess the maturation of the CHOP-INTEND scores in a group of healthy infants, establishing which items of the scale can be reliably used in individuals younger than 3 months.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This is a prospective observational study. The whole cohort was divided into 5 age groups. Each of the 16 CHOP-INTEND items was analyzed looking at the frequency distribution of the scores in each age subgroup. An item was considered developmentally appropriate when\u200a&gt;\u200a85% of the infants achieved a full score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>our study includes 61 assessments collected\u200a&lt;\u200a2 weeks, 25 at 2\u20134 weeks, 20 at 5\u20138 weeks, 25 at 9\u201312 weeks and 20 at 13\u201317 weeks. Eight of the 16 items were developmentally appropriate already in the first week and another by the end of the first month. The remaining 7 items had more variable responses in the first three months and full scores were consistently achieved only after the third month.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Our findings suggest that the CHOP-INTEND can be used before the age of 3 months, but the results should be interpreted with caution, considering which items are developmentally appropriate at the time of testing. This will also help to establish whether the changes observed following early treatments are a sign of efficacy or at least partly reflect maturational aspects.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jnd-221644","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T11:40:08Z","timestamp":1700221208000},"page":"85-90","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":7,"title":["Can the CHOP-INTEND be used as An Outcome Measure in the First Months of Age? Implications for Clinical Trials and Real World Data"],"prefix":"10.1177","volume":"11","author":[{"given":"Costanza","family":"Cutrona","sequence":"first","affiliation":[{"name":"Centro Clinico Nemo Pediatrico, Fondazione Policlinico \u201cA. Gemelli\u201d IRCCS, Rome, Italy"},{"name":"Pediatric Neurology Unit, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"de Sanctis","sequence":"additional","affiliation":[{"name":"Centro Clinico Nemo Pediatrico, Fondazione Policlinico \u201cA. Gemelli\u201d IRCCS, Rome, Italy"},{"name":"Pediatric Neurology Unit, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Coratti","sequence":"additional","affiliation":[{"name":"Centro Clinico Nemo Pediatrico, Fondazione Policlinico \u201cA. Gemelli\u201d IRCCS, Rome, Italy"},{"name":"Pediatric Neurology Unit, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Capasso","sequence":"additional","affiliation":[{"name":"Centro Clinico Nemo Pediatrico, Fondazione Policlinico \u201cA. 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Gemelli\u201d IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meric","family":"Utlulig","sequence":"additional","affiliation":[{"name":"Pediatric Neurology Unit, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Bersani","sequence":"additional","affiliation":[{"name":"Departmen of Woman & Child Health & Pubblic Health, Fondazione Policlinico Universitario \u201cA. Gemelli\u201d IRCCS, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"lazzareschi","sequence":"additional","affiliation":[{"name":"Departmen of Woman & Child Health & Pubblic Health, Fondazione Policlinico Universitario \u201cA. 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