{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:40:37Z","timestamp":1791322837899,"version":"4.3.1"},"reference-count":41,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T00:00:00Z","timestamp":1721001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Neuromuscular Diseases"],"published-print":{"date-parts":[[2024,7,20]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Myotonic dystrophy type 1 (DM1) is a slowly progressive disease caused by abnormal CTG repetitions on the dystrophia myotonica protein kinase ( DMPK) gene. Long mRNA from CTG repetitions stabilizes in nuclear foci and sequester muscleblind-like splicing regulator 1 (MBNL1). Cardinal signs of DM1 include muscle wasting and weakness. The impacts of DM1 progression on skeletal muscle are under-researched.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>Identifying physiopathological markers related to maximal strength loss over time in DM1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Twenty-two individuals with DM1 participated in two maximal isometric muscle strength (MIMS) evaluations of their knee extensors and two vastus lateralis muscle biopsies, 3 years apart. Muscle fiber typing, size (including minimal Feret\u2019s diameter [MFD] and atrophy\/hypertrophy factors [AF\/HF]), and nuclear foci and MBNL1 colocalization (foci\/MBNL1+) were evaluated. Immunoblotting was used to measure glycogen synthase kinase-3 beta (GSK3 \u03b2), p62, LC3BI, LC3BII, and oxidative phosphorylation proteins.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>There are significant correlations between the fold changes of MIMS with type 1 fiber MFD ( \u03c1=\u200a0.483) and AF ( \u03c1=\u200a\u20130.514). Regression analysis shows that baseline percentage of foci\/MBNL1+ nuclei and strength training explain 44.1% of foci\/MBNL1+ nuclei percentage variation over time. There are fair to excellent correlations between the fold changes of MIMS and GSK3 \u03b2 ( \u03c1=\u200a0.327), p62 ( \u03c1=\u200a0.473), LC3BI ( \u03c1=\u200a0.518), LC3BII ( \u03c1=\u200a\u20130.391) and LC3BII\/LC3BI ( \u03c1=\u200a\u20130.773).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Type 1 MFD decrease and AF increase are correlated with MIMS loss. There seems to be a plateau effect in foci\/MBNL1+ nuclei accumulation and strength training helps decrease this accumulation. Autophagy marker LC3BII\/LC3BI ratio has a good biomarker potential of MIMS loss, but more investigations are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jnd-230139","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T11:53:45Z","timestamp":1721390025000},"page":"981-995","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":3,"title":["Changes in Physiopathological Markers in Myotonic Dystrophy Type 1 Skeletal Muscle: A 3-Year Follow-up Study"],"prefix":"10.1177","volume":"11","author":[{"given":"Marie-Pier","family":"Roussel","sequence":"first","affiliation":[{"name":"D\u00e9partement des Sciences Fondamentales, Universit\u00e9 du Qu\u00e9bec \u00e0 Chicoutimi, Saguenay, QC, Canada"},{"name":"Groupe de Recherche Interdisciplinaire sur les Maladies Neuromusculaires (GRIMN), Centre Int\u00e9gr\u00e9 Universitaire de Sant\u00e9 et de Services Sociaux du Saguenay\u2013Lac-Saint-Jean, Saguenay, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6965-7372","authenticated-orcid":false,"given":"Aymeric","family":"Ravel-Chapuis","sequence":"additional","affiliation":[{"name":"\u00c9cole des Sciences Pharmaceutiques, Facult\u00e9 de M\u00e9decine, Universit\u00e9 d\u2019Ottawa, Ottawa, Canada"},{"name":"D\u00e9partement de M\u00e9decine Cellulaire et Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine, Universit\u00e9 d\u2019Ottawa, Ottawa, Canada"},{"name":"Centre de Recherche \u00c9ric-Poulin sur les Maladies Neuromusculaires, Facult\u00e9 de M\u00e9decine, Universit\u00e9 d\u2019Ottawa, Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Gobin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Cellulaire et Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine, Universit\u00e9 d\u2019Ottawa, Ottawa, Canada"},{"name":"Centre de Recherche \u00c9ric-Poulin sur les Maladies Neuromusculaires, Facult\u00e9 de M\u00e9decine, Universit\u00e9 d\u2019Ottawa, Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5798-4475","authenticated-orcid":false,"given":"Bernard J.","family":"Jasmin","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Cellulaire et Mol\u00e9culaire, Facult\u00e9 de M\u00e9decine, Universit\u00e9 d\u2019Ottawa, Ottawa, Canada"},{"name":"Centre de Recherche \u00c9ric-Poulin sur les Maladies Neuromusculaires, Facult\u00e9 de M\u00e9decine, Universit\u00e9 d\u2019Ottawa, Ottawa, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7637-5445","authenticated-orcid":false,"given":"Jean-Philippe","family":"Leduc-Gaudet","sequence":"additional","affiliation":[{"name":"Groupe de Recherche en Signalisation Cellulaire, D\u00e9partement de Biologie M\u00e9dicale, Universit\u00e9 du Qu\u00e9bec \u00e0 Trois-Rivi\u00e8res, Trois-Rivi\u00e8res, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2829-8470","authenticated-orcid":false,"given":"Cynthia","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Interdisciplinaire sur les Maladies Neuromusculaires (GRIMN), Centre Int\u00e9gr\u00e9 Universitaire de Sant\u00e9 et de Services Sociaux du Saguenay\u2013Lac-Saint-Jean, Saguenay, QC, Canada"},{"name":"Facult\u00e9 de M\u00e9decine et des Sciences de la Sant\u00e9, Universit\u00e9 de Sherbrooke, Sherbrooke, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9953-8315","authenticated-orcid":false,"given":"Elise","family":"Duchesne","sequence":"additional","affiliation":[{"name":"Groupe de Recherche Interdisciplinaire sur les Maladies Neuromusculaires (GRIMN), Centre Int\u00e9gr\u00e9 Universitaire de Sant\u00e9 et de Services Sociaux du Saguenay\u2013Lac-Saint-Jean, Saguenay, QC, Canada"},{"name":"\u00c9cole des Sciences de la R\u00e9adaptation, Facult\u00e9 de M\u00e9decine, Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"},{"name":"Centre Interdisciplinaire de Recherche en R\u00e9adaptation et Int\u00e9gration Sociale (Cirris), Centre Int\u00e9gr\u00e9 Universitaire de Sant\u00e9 et de Services Sociaux Capitale-Nationale, Qu\u00e9bec, QC, Canada"},{"name":"CHU de Qu\u00e9bec - Centre de Recherche de l\u2019Universit\u00e9 Laval, Qu\u00e9bec, QC, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,7,15]]},"reference":[{"key":"ref001","unstructured":"HarperPS. 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