{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:07:56Z","timestamp":1789715276131,"version":"4.0.1"},"reference-count":0,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:p>Background: Parkinson's disease (PD) is associated with neurodegeneration of dopaminergic neurons and an accompanying neuroinflammatory process in the substantia nigra (SN). The cholinergic anti-inflammatory signalling pathway allows the autonomic nervous system to modulate immunologic stimuli and inflammatory processes. A major component of this pathway is the \u03b17 nicotinic acetylcholine receptor (\u03b17 nACh receptor), which is expressed on immune cells such as microglia. Objective: To determine the role of this cholinergic anti-inflammatory signalling pathway, we investigated the effects of the selective \u03b17 nACh agonist PNU-282987 and of the non-competitive nACh antagonist mecamylamine on microglia-induced neuroinflammation and toxin-induced degeneration of dopaminergic neurons in a mouse model of PD. Methods: PNU-282987, mecamylamine or placebo administration was started one day before MPTP intoxication and repeated daily until sacrifice after MPTP intoxication. C57Bl\/6 mice were injected intraperitoneally four times at 2 h intervals with either 20 mg\/kg MPTP-HCl or a corresponding volume of saline. Two or seven days after the end of the MPTP intoxication, the animals were killed and their brains were processed for further analysis. Results: Treatment with PNU-282987 resulted in an attenuation of neuroinflammation in the MPTP-lesioned SN. Furthermore, PNU-282987 attenuated MPTP-induced dopaminergic cell loss in the SN and reduced striatal dopamine depletion. Unexpectedly, mecamylamine lowered neuroinflammation as well, though it did not show a neuroprotective potential at the nigral level. Conclusions: Our results demonstrate the therapeutic potential of the selective \u03b17 nicotinic acetylcholine agonist PNU-282987 in attenuating neuroinflammation and toxin-induced loss of dopaminergic neurons in the acute MPTP mouse model of PD.<\/jats:p>","DOI":"10.3233\/jpd-120157","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T13:56:00Z","timestamp":1575381360000},"page":"161-172","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["The \u03b17 nAChR Agonist PNU-282987 Reduces Inflammation and MPTP-Induced                     Nigral Dopaminergic Cell Loss in Mice"],"prefix":"10.1177","volume":"3","author":[{"given":"Vanessa","family":"Stuckenholz","sequence":"first","affiliation":[{"name":"Department of Neurology, Philipps-University of Marburg,\r                    Baldingerstrasse, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bacher","sequence":"additional","affiliation":[{"name":"Institute of Immunology, Philipps-University of Marburg,\r                    Baldingerstrasse, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Balzer-Geldsetzer","sequence":"additional","affiliation":[{"name":"Department of Neurology, Philipps-University of Marburg,\r                    Baldingerstrasse, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Alvarez-Fischer","sequence":"additional","affiliation":[{"name":"Institute of Neurogenetics, University of L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang H.","family":"Oertel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Philipps-University of Marburg,\r                    Baldingerstrasse, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Dodel","sequence":"additional","affiliation":[{"name":"Department of Neurology, Philipps-University of Marburg,\r                    Baldingerstrasse, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Noelker","sequence":"additional","affiliation":[{"name":"Department of Neurology, Philipps-University of Marburg,\r                    Baldingerstrasse, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,1,1]]},"container-title":["Journal of Parkinson\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-120157","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-120157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:42:05Z","timestamp":1777610525000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JPD-120157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,5,1]]}},"alternative-id":["10.3233\/JPD-120157"],"URL":"https:\/\/doi.org\/10.3233\/jpd-120157","relation":{},"ISSN":["1877-7171","1877-718X"],"issn-type":[{"value":"1877-7171","type":"print"},{"value":"1877-718X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,1]]}}}