{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:42:03Z","timestamp":1784266923568,"version":"3.55.0"},"reference-count":0,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2014,2,1]]},"abstract":"<jats:p>The pathological process affects the peripheral autonomic nervous system in the vast majority of sporadic PD patients. Recent reports have shown that patients with a familial form of the disease caused by mutation of the gene encoding LRRK2 and alpha-synuclein also display autonomic abnormalities, especially cardiac sympathetic denervation. In the present report, we have studied the involvement of the peripheral autonomic system in a patient with Gaucher disease-associated parkinsonism. Using colonic biopsies and quantitative 123I-MIBG scintigraphy respectively, we show that both Lewy pathology and cardiac denervation were present in this case of Gaucher-associated Parkinsonism. We discuss the consequence of these findings on the pathophysiology of the disease.<\/jats:p>","DOI":"10.3233\/jpd-130333","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T14:10:41Z","timestamp":1575382241000},"page":"29-32","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Peripheral Autonomic Nervous System Involvement in Gaucher-Related                     Parkinsonism"],"prefix":"10.1177","volume":"4","author":[{"given":"Thibaud","family":"Lebouvier","sequence":"first","affiliation":[{"name":"Inserm, U913, Nantes, France"},{"name":"Inserm, CIC-04, Nantes, France"},{"name":"University Nantes, Nantes, France"},{"name":"CHU Nantes, Department of Neurology, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Clairembault","sequence":"additional","affiliation":[{"name":"Inserm, U913, Nantes, France"},{"name":"Inserm, CIC-04, Nantes, France"},{"name":"University Nantes, Nantes, France"},{"name":"CHU Nantes, Department of Neurology, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Devos","sequence":"additional","affiliation":[{"name":"Inserm, U913, Nantes, France"},{"name":"Inserm, CIC-04, Nantes, France"},{"name":"University Nantes, Nantes, France"},{"name":"CHU Nantes, Department of Neurology, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Pallardy","sequence":"additional","affiliation":[{"name":"Nuclear Medicine Department, Ren\u00e9 Gauducheau Cancer Center, Boulevard\r                    Jacques Monod, Saint Herblain, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Coron","sequence":"additional","affiliation":[{"name":"Inserm, U913, Nantes, France"},{"name":"Inserm, CIC-04, Nantes, France"},{"name":"University Nantes, Nantes, France"},{"name":"CHU Nantes, Institut des Maladies de l'Appareil Digestif, Nantes,\r                    France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Neunlist","sequence":"additional","affiliation":[{"name":"Inserm, U913, Nantes, France"},{"name":"University Nantes, Nantes, France"},{"name":"CHU Nantes, Institut des Maladies de l'Appareil Digestif, Nantes,\r                    France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Derkinderen","sequence":"additional","affiliation":[{"name":"Inserm, U913, Nantes, France"},{"name":"Inserm, CIC-04, Nantes, France"},{"name":"University Nantes, Nantes, France"},{"name":"CHU Nantes, Department of Neurology, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,1,1]]},"container-title":["Journal of Parkinson\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-130333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-130333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:43:00Z","timestamp":1777610580000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JPD-130333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,2,1]]}},"alternative-id":["10.3233\/JPD-130333"],"URL":"https:\/\/doi.org\/10.3233\/jpd-130333","relation":{"is-cited-by":[{"id-type":"doi","id":"10.1007\/978-4-431-56012-8_15","asserted-by":"object"}]},"ISSN":["1877-7171","1877-718X"],"issn-type":[{"value":"1877-7171","type":"print"},{"value":"1877-718X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,1,1]]}}}