{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:41:35Z","timestamp":1791204095911,"version":"4.2.0"},"reference-count":62,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2015,6,1]],"date-time":"2015-06-01T00:00:00Z","timestamp":1433116800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2015,6,1]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>MPTP and paraquat are two compounds that have been used to model Parkinson\u2019s disease in mice. Previous studies in two non-traditional strains of mice have shown that a single dose of MPTP can induce changes in body temperature, while the effects of paraquat have not been examined. Examination of body temperature is important since small fluctuations in an animal\u2019s core temperature can significantly affect drug metabolism, and if significant enough can even culminate in an animal\u2019s death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To determine how external heating can alter the survival of C57BL\/6J mice following MPTP administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>In this study, we examine the effects of MPTP (4\u00d720\u200amg\/kg, 2 hours apart) and paraquat (2\u00d710\u200amg\/kg\/week for 3 weeks) on core temperature of C57BL\/6J mice. Correlations of purine and catecholamine levels were also done in mice treated with MPTP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>We find that MPTP induces a significant hypothermia in C57BL\/6J mice that reduces their core temperature below the limit of fatal hypothermia. Unlike MPTP, paraquat did not induce a significant hypothermia. Placement of animals on heating pads significantly abrogates the loss of core temperature. In both heated and non-heated conditions, mice treated with MPTP showed a significant depletion of ATP within 2 hours of administration in both striatum and SN that started to recover 2 hours after MPTP administration was complete. Striatal DA and DOPAC are significantly reduced starting 4\u20136 hours after MPTP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>The fatal hypothermic effects of MPTP can be abrogated through use of external heating.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-140424","type":"journal-article","created":{"date-parts":[[2015,6,2]],"date-time":"2015-06-02T17:44:58Z","timestamp":1433267098000},"page":"389-401","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":12,"title":["Acute Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) or Paraquat on Core Temperature in C57BL\/6J Mice"],"prefix":"10.1177","volume":"5","author":[{"given":"Yun","family":"Jiao","sequence":"first","affiliation":[{"name":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuchen","family":"Dou","sequence":"additional","affiliation":[{"name":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgina","family":"Lockwood","sequence":"additional","affiliation":[{"name":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, TN, USA"},{"name":"Department of Biochemistry, University of Bath, Bath, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Pani","sequence":"additional","affiliation":[{"name":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard Jay","family":"Smeyne","sequence":"additional","affiliation":[{"name":"Department of Developmental Neurobiology, St. Jude Children\u2019s Research Hospital, Memphis, TN, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2015,6,1]]},"reference":[{"key":"r1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6823561"},{"key":"r2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.877545"},{"key":"r3","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1002839"},{"key":"r4","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp006"},{"key":"r5","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1996.0054"},{"key":"r6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M404596200"},{"key":"r7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2011.02.012"},{"key":"r8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029447"},{"key":"r9","doi-asserted-by":"publisher","DOI":"10.1177\/096032719201100616"},{"key":"r10","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2013.12.010"},{"key":"r11","unstructured":"Woolley DE, Gietzen DW, Gee SJ, Magdalou J, Hammock BD 1989 Does paraquat (PQ) mimic MPP+ toxicity? 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