{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:46:42Z","timestamp":1792198002994,"version":"4.4.0"},"reference-count":17,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,1,9]],"date-time":"2016-01-09T00:00:00Z","timestamp":1452297600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2016,3,30]]},"abstract":"<jats:p>Type 1 Gaucher\u2019s disease (GD1) is traditionally regarded as \u201cnon-neurological\u201d. Spatiotemporal and kinematic analysis of gait was carried on thirteen GD1 patients and thirteen healthy controls. We identified a previously unknown subclinical reduction of amplitude of movements in GD1. Articular excursion of ankle, knee and hip was reduced during the swing phase of gait ( p\u200a&lt; \u200a0.0001). Furthermore, the excursion of the knee appeared also significantly more asymmetric in GD1 patients ( p\u200a=\u200a0.02). Correction for age, BMI and basal walking speed did not modify the significance. Accordingly to the recent observations that GD1 predisposes to Parkinson\u2019s disease, the impaired and asymmetric gait kinematics that we observed might be interpreted as a form of extrapyramidal involvement.<\/jats:p>","DOI":"10.3233\/jpd-150660","type":"journal-article","created":{"date-parts":[[2016,4,6]],"date-time":"2016-04-06T12:23:33Z","timestamp":1459945413000},"page":"191-195","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":20,"title":["Impaired gait kinematics in type 1 Gaucher\u2019s Disease"],"prefix":"10.1177","volume":"6","author":[{"given":"Pierpaolo","family":"Sorrentino","sequence":"first","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Italy"},{"name":"Department of Clinical Neurophysiology, VUmc, Amsterdam, Nederlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Barbato","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Naples Federico II, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Del Gaudio","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"Rucco","sequence":"additional","affiliation":[{"name":"Department of Motor Sciences and Wellness, University of Naples Parthenope, Italy"},{"name":"Institute Hermitage-Capodimonte, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Varriale","sequence":"additional","affiliation":[{"name":"Department of Motor Sciences and Wellness, University of Naples Parthenope, Italy"},{"name":"Institute Hermitage-Capodimonte, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelina","family":"Sibilio","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, Moscati Hospital, Aversa (CE), Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Strazzullo","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Naples Federico II, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Sorrentino","sequence":"additional","affiliation":[{"name":"Department of Motor Sciences and Wellness, University of Naples Parthenope, Italy"},{"name":"Institute Hermitage-Capodimonte, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Agosti","sequence":"additional","affiliation":[{"name":"Department of Motor Sciences and Wellness, University of Naples Parthenope, Italy"},{"name":"Institute Hermitage-Capodimonte, Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2016,1,9]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(65)90743-6"},{"key":"ref002","unstructured":"LongoD, FauciA, KasperD, HauserS, JamesonJ, & LoscalzoJ (2011) Harrison\u2019s principles of internal medicine. 18th ed.,McGraw-Hill Professional, United States."},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq198"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-130333"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24945"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0901281"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.3109\/07853890.2013.849003"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/0167-9457(91)90046-Z"},{"key":"ref009","unstructured":"LevangiePK, & NorkinC (2011) Joint Structure and Function: A Comprehensive Analysis. 5th ed. 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