{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:13:28Z","timestamp":1793412808407,"version":"4.5.0"},"reference-count":38,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,3,6]],"date-time":"2017-03-06T00:00:00Z","timestamp":1488758400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2017,3,20]]},"abstract":"<jats:p>Background: Differentiating Parkinson\u2019s disease and atypical parkinsonism on clinical parameters is challenging, especially in early disease courses. This is due to large overlap in symptoms and because the so called red flags, i.e. symptoms indicating atypical parkinsonism, have not (fully) developed. Brain MRI can aid to improve the accuracy and confidence about the diagnosis.<\/jats:p>\n                  <jats:p>Objective and Methods: In the current paper, we discuss when brain MRI should be performed in the diagnostic work-up of parkinsonism, our preferred brain MRI scanning protocol, and the diagnostic value of specific abnormalities.<\/jats:p>\n                  <jats:p>Results and Conclusions: The main purpose of brain MRI is to assess cerebrovascular damage, and to exclude other possible \u2013 and sometimes treatable \u2013 causes of parkinsonism, such as normal pressure hydrocephalus. Furthermore, brain MRI can support the possible or probable diagnosis of a specific form of atypical parkinsonism.<\/jats:p>","DOI":"10.3233\/jpd-150733","type":"journal-article","created":{"date-parts":[[2017,3,7]],"date-time":"2017-03-07T10:27:29Z","timestamp":1488882449000},"page":"211-217","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":32,"title":["Clinical Application of Brain MRI in the Diagnostic Work-up of Parkinsonism"],"prefix":"10.1177","volume":"7","author":[{"given":"Frederick J.A.","family":"Meijer","sequence":"first","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bozena","family":"Goraj","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Radboud University Medical Center, Nijmegen, The Netherlands"},{"name":"Department of Diagnostic Imaging, Medical Center of Postgraduate Education, Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastiaan R.","family":"Bloem","sequence":"additional","affiliation":[{"name":"Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rianne A.J.","family":"Esselink","sequence":"additional","affiliation":[{"name":"Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The 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