{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:54:24Z","timestamp":1777888464238,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2016,10,12]],"date-time":"2016-10-12T00:00:00Z","timestamp":1476230400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2016,10,12]]},"abstract":"<jats:p>In a prospective study, we recently discovered 8 clinical predictors of dementia in Parkinson\u2019s disease. Here, we validate these dementia predictors using two additional prospective cohorts ( n\u200a=\u200a134). After a 3.6-year follow-up, 35\/134 developed dementia (7.2% per year). When confirming individual variables, 5\/8 were significantly associated with dementia in the validation cohort. These included age, male sex, baseline RBD, orthostatic hypotension, and MCI. Bilateral onset, hallucinations and falls\/freezing did not significantly predict dementia; however, point estimates of OR were all\u200a&gt;1. In all cohorts, the strongest determinant for dementia development was the co-existence of RBD, MCI and orthostatic hypotension at baseline.<\/jats:p>","DOI":"10.3233\/jpd-160925","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T10:28:26Z","timestamp":1480674506000},"page":"159-162","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":45,"title":["Dementia Predictors in Parkinson Disease: A Validation Study"],"prefix":"10.1177","volume":"7","author":[{"given":"Julius B.M.","family":"Anang","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Brain and Neurosciences, Division of Neurology, Faculty of Medicine, Tottori University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia Rios","family":"Romenets","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Nakashima","sequence":"additional","affiliation":[{"name":"Department of Brain and Neurosciences, Division of Neurology, Faculty of Medicine, Tottori University, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Francois","family":"Gagnon","sequence":"additional","affiliation":[{"name":"Centre d\u2019\u00c9tudes Avanc\u00e9es en M\u00e9decine du Sommeil, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, QC, Canada"},{"name":"Department of Psychology, Universit\u00e9 du Qu\u00e9bec \u00e0 Montr\u00e9al, Montreal, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald B.","family":"Postuma","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada"},{"name":"Centre d\u2019\u00c9tudes Avanc\u00e9es en M\u00e9decine du Sommeil, H\u00f4pital du Sacr\u00e9-Coeur de Montr\u00e9al, Montr\u00e9al, QC, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2016,11,30]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000842"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12375"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1017\/cjn.2014.3"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31827b1a07"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1002\/mds.24939"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp245"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.0703"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.08.013"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2013.03.003"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2012.10.011"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21844"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2005.53221.x"},{"key":"ref013","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25086"},{"key":"ref014","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2009.00369.x"}],"container-title":["Journal of Parkinson\u2019s Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-160925","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.3233\/JPD-160925","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.3233\/JPD-160925","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T04:45:35Z","timestamp":1777610735000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.3233\/JPD-160925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10,12]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,10,12]]}},"alternative-id":["10.3233\/JPD-160925"],"URL":"https:\/\/doi.org\/10.3233\/jpd-160925","relation":{},"ISSN":["1877-7171","1877-718X"],"issn-type":[{"value":"1877-7171","type":"print"},{"value":"1877-718X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,10,12]]}}}