{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T09:54:29Z","timestamp":1777888469608,"version":"3.51.4"},"reference-count":51,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2017,3,20]],"date-time":"2017-03-20T00:00:00Z","timestamp":1489968000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2017,3,20]]},"abstract":"<jats:p>Background: Olfactory impairment is an early manifestation of Parkinson\u2019s disease (PD). Diffusion Tensor Imaging (DTI) and Magnetization Transfer (MT) are two imaging techniques that allow noninvasive detection of microstructural changes in the cerebral white matter.<\/jats:p>\n                  <jats:p>Objective: To assess white matter alterations associated with olfactory impairment in PD, using a binary imaging approach with DTI and MT.<\/jats:p>\n                  <jats:p>Methods: 22 PD patients and 13 healthy controls were examined with DTI, MT and an odor discrimination test. DTI data were first analyzed with tract-based spatial statistics (TBSS) in order to detect differences in fractional anisotropy, mean, radial and axial diffusivity between PD patients and controls. Voxelwise randomized permutation was employed for the MT analysis, after spatial and intensity normalization. Additionally, ROI analysis was performed on both the DTI and MT data, focused on the white matter adjacent to olfactory brain regions.<\/jats:p>\n                  <jats:p>Results: Whole brain voxelwise analysis revealed decreased axial diffusivity in the left uncinate fasciculus and the white matter adjacent to the left olfactory sulcus of PD patients. ROI analysis demonstrated decreased axial diffusivity in the right orbitofrontal cortex, as well as decreased mean diffusivity and axial diffusivity in the white matter of the left entorhinal cortex of PD patients. There were no significant differences regarding fractional anisotropy, radial diffusivity or MT between patients and controls.<\/jats:p>\n                  <jats:p>Conclusions: ROI analysis of DTI could detect microstructural changes in the white matter adjacent to olfactory areas in PD patients, whereas MT imaging could not.<\/jats:p>","DOI":"10.3233\/jpd-161060","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T11:59:49Z","timestamp":1493985589000},"page":"301-311","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":35,"title":["Olfactory Impairment in Parkinson\u2019s Disease Studied with Diffusion Tensor and\u00a0Magnetization Transfer Imaging"],"prefix":"10.1177","volume":"7","author":[{"given":"Charalampos","family":"Georgiopoulos","sequence":"first","affiliation":[{"name":"Department of Radiology and Department ofMedical and Health Sciences, Link\u00f6ping University, Link\u00f6ping, \u00a0Sweden"},{"name":"Center for Medical ImageScience and Visualization (CMIV), Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcel","family":"Warntjes","sequence":"additional","affiliation":[{"name":"Center for Medical ImageScience and Visualization (CMIV), Link\u00f6ping University, Link\u00f6ping, Sweden"},{"name":"SyntheticMR AB, Link\u00f6ping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nil","family":"Dizdar","sequence":"additional","affiliation":[{"name":"Department of Neurologyand Department of Clinical and Experimental Medicine, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helene","family":"Zachrisson","sequence":"additional","affiliation":[{"name":"Center for Medical ImageScience and Visualization (CMIV), Link\u00f6ping University, Link\u00f6ping, Sweden"},{"name":"Department of Clinical 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