{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:08:48Z","timestamp":1790122128059,"version":"4.0.1"},"reference-count":45,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:00:00Z","timestamp":1528156800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Journal of Parkinson\u2019s Disease"],"published-print":{"date-parts":[[2018,6,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Non-motor symptoms (NMS) are common in late stage Parkinson\u2019s disease (PD), as the frequency and severity of most of these symptoms increase with advancing disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To assess effect of dopaminergic therapy on NMS in late stage PD and to investigate relationships between dopaminergic effect on NMS and on motor function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>Thirty PD patients in Hoehn and Yahr (HY) stages IV and V in \u201con\u201d were included. Dopaminergic effect on non-motor symptomatology was assessed by the modified version of the Non-Motor Symptoms Scale (NMSS) in the \u201coff\u201d and the \u201con\u201d state during a standardized L-dopa test, in parallel also assessing motor function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>NMS were common and many of the symptoms occurred in\u200a&gt;80% of the individuals. The highest NMSS scores were seen within the NMSS domains 3: mood\/apathy and 7: urinary in both the \u201coff\u201d and the \u201con\u201d state. There was a statistically significant ( p\u200a&lt;\u200a0.001) improvement in the modified NMSS total score (median) from 79 in \u201coff\u201d to 64 in \u201con\u201d. There were statistically significant differences between the \u201coff\u201d and the \u201con\u201d state for domains 2: sleep\/fatigue, 3: mood\/apathy, 5: attention\/memory, 6: gastrointestinal and 7: urinary. The differences in the NMSS score between the \u201coff\u201d and the \u201con\u201d state were in general larger for motor responders than for motor non-responders. In motor non-responders, differences of the NMSS score between the \u201coff\u201d and the \u201con\u201d state were found for the total score, domain 3: mood\/apathy and its item 11-flat moods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>There is an effect of dopaminergic medication on NMS in late stage PD, to some extent also for those with a non-significant response on motor function during L-dopa test. It is therefore of importance to optimize dopaminergic therapy in order to give the most effective symptomatic treatment possible.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3233\/jpd-181380","type":"journal-article","created":{"date-parts":[[2018,7,27]],"date-time":"2018-07-27T19:33:59Z","timestamp":1532720039000},"page":"409-420","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":22,"title":["Dopaminergic Effect on Non-Motor Symptoms in Late Stage Parkinson\u2019s Disease"],"prefix":"10.1177","volume":"8","author":[{"given":"Kristina","family":"Rosqvist","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences Lund, Lund University, Faculty of Medicine, Neurology, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Odin","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences Lund, Lund University, Faculty of Medicine, Neurology, Lund, Sweden"},{"name":"Department of Neurology and Rehabilitation Medicine, Sk\u00e5ne University Hospital, Lund, Sweden"},{"name":"Department of Neurology, Central Hospital, Bremerhaven, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hagell","sequence":"additional","affiliation":[{"name":"The PRO-CARE Group, Faculty of Health Science, Kristianstad University, Kristianstad, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne","family":"Iwarsson","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Lund University, Faculty of Medicine, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria H.","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Lund University, Faculty of Medicine, Lund, Sweden"},{"name":"Memory Clinic, Sk\u00e5ne University Hospital, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Storch","sequence":"additional","affiliation":[{"name":"Department of Neurology, University of Rostock, Rostock, Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE), Rostock, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2018,7,27]]},"reference":[{"key":"ref001","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20460"},{"key":"ref002","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70373-8"},{"key":"ref003","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22643"},{"key":"ref004","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.126"},{"key":"ref005","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2017.02.007"},{"key":"ref006","doi-asserted-by":"publisher","DOI":"10.1002\/mds.23462"},{"key":"ref007","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.17.5.427"},{"key":"ref008","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.12458"},{"key":"ref009","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-010-5566-8"},{"key":"ref010","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-150656"},{"key":"ref011","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.02.021"},{"key":"ref012","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-171181"},{"key":"ref013","first-page":"293","volume":"2","author":"Fahn S","year":"1987","journal-title":"Recent Developments in Parkinson\u2019s Disease"},{"key":"ref014","first-page":"152","author":"Schwab REA","year":"1969","journal-title":"Third symposium on Parkinson\u2019s disease,"},{"key":"ref015","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"ref016","unstructured":"The CLaSP study. 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